Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.

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Fältnamn	Indikatorer	Metadata
000		09187naa a2202101 4500
001		oai:DiVA.org:umu-32410
003		SwePub
008		100311s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:119136596
009		oai:lup.lub.lu.se:e86542bb-e6d1-4077-9b7f-fa0cfe38951a
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-324102 URI
024	7	a https://doi.org/10.1371/journal.pgen.10005082 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1191365962 URI
024	7	a https://lup.lub.lu.se/record/16181492 URI
040		a (SwePub)umud (SwePub)kid (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Lindgren, Cecilia M4 aut
245	1 0	a Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
264		c 2009-06-26
264	1	b Public Library of Science (PLoS),c 2009
338		a print2 rdacarrier
520		a To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653		a MEDICINE
653		a MEDICIN
700	1	a Heid, Iris M4 aut
700	1	a Randall, Joshua C4 aut
700	1	a Lamina, Claudia4 aut
700	1	a Steinthorsdottir, Valgerdur4 aut
700	1	a Qi, Lu4 aut
700	1	a Speliotes, Elizabeth K4 aut
700	1	a Thorleifsson, Gudmar4 aut
700	1	a Willer, Cristen J4 aut
700	1	a Herrera, Blanca M4 aut
700	1	a Jackson, Anne U4 aut
700	1	a Lim, Noha4 aut
700	1	a Scheet, Paul4 aut
700	1	a Soranzo, Nicole4 aut
700	1	a Amin, Najaf4 aut
700	1	a Aulchenko, Yurii S4 aut
700	1	a Chambers, John C4 aut
700	1	a Drong, Alexander4 aut
700	1	a Luan, Jian'an4 aut
700	1	a Lyon, Helen N4 aut
700	1	a Rivadeneira, Fernando4 aut
700	1	a Sanna, Serena4 aut
700	1	a Timpson, Nicholas J4 aut
700	1	a Zillikens, M Carola4 aut
700	1	a Zhao, Jing Hua4 aut
700	1	a Almgren, Peteru Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-pal
700	1	a Bandinelli, Stefania4 aut
700	1	a Bennett, Amanda J4 aut
700	1	a Bergman, Richard N4 aut
700	1	a Bonnycastle, Lori L4 aut
700	1	a Bumpstead, Suzannah J4 aut
700	1	a Chanock, Stephen J4 aut
700	1	a Cherkas, Lynn4 aut
700	1	a Chines, Peter4 aut
700	1	a Coin, Lachlan4 aut
700	1	a Cooper, Cyrus4 aut
700	1	a Crawford, Gabriel4 aut
700	1	a Doering, Angela4 aut
700	1	a Dominiczak, Anna4 aut
700	1	a Doney, Alex S F4 aut
700	1	a Ebrahim, Shah4 aut
700	1	a Elliott, Paul4 aut
700	1	a Erdos, Michael R4 aut
700	1	a Estrada, Karol4 aut
700	1	a Ferrucci, Luigi4 aut
700	1	a Fischer, Guido4 aut
700	1	a Forouhi, Nita G4 aut
700	1	a Gieger, Christian4 aut
700	1	a Grallert, Harald4 aut
700	1	a Groves, Christopher J4 aut
700	1	a Grundy, Scott4 aut
700	1	a Guiducci, Candace4 aut
700	1	a Hadley, David4 aut
700	1	a Hamsten, Andersu Karolinska Institutet4 aut
700	1	a Havulinna, Aki S4 aut
700	1	a Hofman, Albert4 aut
700	1	a Holle, Rolf4 aut
700	1	a Holloway, John W4 aut
700	1	a Illig, Thomas4 aut
700	1	a Isomaa, Bo4 aut
700	1	a Jacobs, Leonie C4 aut
700	1	a Jameson, Karen4 aut
700	1	a Jousilahti, Pekka4 aut
700	1	a Karpe, Fredrik4 aut
700	1	a Kuusisto, Johanna4 aut
700	1	a Laitinen, Jaana4 aut
700	1	a Lathrop, G Mark4 aut
700	1	a Lawlor, Debbie A4 aut
700	1	a Mangino, Massimo4 aut
700	1	a McArdle, Wendy L4 aut
700	1	a Meitinger, Thomas4 aut
700	1	a Morken, Mario A4 aut
700	1	a Morris, Andrew P4 aut
700	1	a Munroe, Patricia4 aut
700	1	a Narisu, Narisu4 aut
700	1	a Nordström, Annau Umeå universitet,Idrottsmedicin,Geriatrik4 aut0 (Swepub:umu)anagun97
700	1	a Nordström, Peteru Umeå universitet,Idrottsmedicin,Geriatrik4 aut0 (Swepub:umu)peno0014
700	1	a Oostra, Ben A4 aut
700	1	a Palmer, Colin N A4 aut
700	1	a Payne, Felicity4 aut
700	1	a Peden, John F4 aut
700	1	a Prokopenko, Inga4 aut
700	1	a Renström, Fridau Umeå universitet,Medicin4 aut0 (Swepub:umu)frre0001
700	1	a Ruokonen, Aimo4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Sandhu, Manjinder S4 aut
700	1	a Scott, Laura J4 aut
700	1	a Scuteri, Angelo4 aut
700	1	a Silander, Kaisa4 aut
700	1	a Song, Kijoung4 aut
700	1	a Yuan, Xin4 aut
700	1	a Stringham, Heather M4 aut
700	1	a Swift, Amy J4 aut
700	1	a Tuomi, Tiinamaija4 aut
700	1	a Uda, Manuela4 aut
700	1	a Vollenweider, Peter4 aut
700	1	a Waeber, Gerard4 aut
700	1	a Wallace, Chris4 aut
700	1	a Walters, G Bragi4 aut
700	1	a Weedon, Michael N4 aut
700	1	a Witteman, Jacqueline C M4 aut
700	1	a Zhang, Cuilin4 aut
700	1	a Zhang, Weihua4 aut
700	1	a Caulfield, Mark J4 aut
700	1	a Collins, Francis S4 aut
700	1	a Davey Smith, George4 aut
700	1	a Day, Ian N M4 aut
700	1	a Franks, Paul Wu Lund University,Lunds universitet,Umeå universitet,Medicin,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf
700	1	a Hattersley, Andrew T4 aut
700	1	a Hu, Frank B4 aut
700	1	a Jarvelin, Marjo-Riitta4 aut
700	1	a Kong, Augustine4 aut
700	1	a Kooner, Jaspal S4 aut
700	1	a Laakso, Markku4 aut
700	1	a Lakatta, Edward4 aut
700	1	a Mooser, Vincent4 aut
700	1	a Morris, Andrew D4 aut
700	1	a Peltonen, Leena4 aut
700	1	a Samani, Nilesh J4 aut
700	1	a Spector, Timothy D4 aut
700	1	a Strachan, David P4 aut
700	1	a Tanaka, Toshiko4 aut
700	1	a Tuomilehto, Jaakko4 aut
700	1	a Uitterlinden, André G4 aut
700	1	a van Duijn, Cornelia M4 aut
700	1	a Wareham, Nicholas J4 aut
700	1	a Waterworth, Dawn M4 aut
700	1	a Boehnke, Michael4 aut
700	1	a Deloukas, Panos4 aut
700	1	a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
700	1	a Hunter, David J4 aut
700	1	a Thorsteinsdottir, Unnur4 aut
700	1	a Schlessinger, David4 aut
700	1	a Wichmann, H-Erich4 aut
700	1	a Frayling, Timothy M4 aut
700	1	a Abecasis, Gonçalo R4 aut
700	1	a Hirschhorn, Joel N4 aut
700	1	a Loos, Ruth J F4 aut
700	1	a Stefansson, Kari4 aut
700	1	a Mohlke, Karen L4 aut
700	1	a Barroso, Inês4 aut
700	1	a McCarthy, Mark I4 aut
710	2	a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
773	0	t PLoS geneticsd : Public Library of Science (PLoS)g 5:6, s. e1000508-q 5:6<e1000508-x 1553-7404
856	4	u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000508&type=printable
856	4	u http://dx.doi.org/10.1371/journal.pgen.1000508x freey FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-32410
856	4 8	u https://doi.org/10.1371/journal.pgen.1000508
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:119136596
856	4 8	u https://lup.lub.lu.se/record/1618149

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Av författaren/redakt...: Lindgren, Cecili ...; Heid, Iris M; Randall, Joshua ...; Lamina, Claudia; Steinthorsdottir ...; Qi, Lu; visa fler...; Speliotes, Eliza ...; Thorleifsson, Gu ...; Willer, Cristen ...; Herrera, Blanca ...; Jackson, Anne U; Lim, Noha; Scheet, Paul; Soranzo, Nicole; Amin, Najaf; Aulchenko, Yurii ...; Chambers, John C; Drong, Alexander; Luan, Jian'an; Lyon, Helen N; Rivadeneira, Fer ...; Sanna, Serena; Timpson, Nichola ...; Zillikens, M Car ...; Zhao, Jing Hua; Almgren, Peter; Bandinelli, Stef ...; Bennett, Amanda ...; Bergman, Richard ...; Bonnycastle, Lor ...; Bumpstead, Suzan ...; Chanock, Stephen ...; Cherkas, Lynn; Chines, Peter; Coin, Lachlan; Cooper, Cyrus; Crawford, Gabrie ...; Doering, Angela; Dominiczak, Anna; Doney, Alex S F; Ebrahim, Shah; Elliott, Paul; Erdos, Michael R; Estrada, Karol; Ferrucci, Luigi; Fischer, Guido; Forouhi, Nita G; Gieger, Christia ...; Grallert, Harald; Groves, Christop ...; Grundy, Scott; Guiducci, Candac ...; Hadley, David; Hamsten, Anders; Havulinna, Aki S; Hofman, Albert; Holle, Rolf; Holloway, John W; Illig, Thomas; Isomaa, Bo; Jacobs, Leonie C; Jameson, Karen; Jousilahti, Pekk ...; Karpe, Fredrik; Kuusisto, Johann ...; Laitinen, Jaana; Lathrop, G Mark; Lawlor, Debbie A; Mangino, Massimo; McArdle, Wendy L; Meitinger, Thoma ...; Morken, Mario A; Morris, Andrew P; Munroe, Patricia; Narisu, Narisu; Nordström, Anna; Nordström, Peter; Oostra, Ben A; Palmer, Colin N ...; Payne, Felicity; Peden, John F; Prokopenko, Inga; Renström, Frida; Ruokonen, Aimo; Salomaa, Veikko; Sandhu, Manjinde ...; Scott, Laura J; Scuteri, Angelo; Silander, Kaisa; Song, Kijoung; Yuan, Xin; Stringham, Heath ...; Swift, Amy J; Tuomi, Tiinamaij ...; Uda, Manuela; Vollenweider, Pe ...; Waeber, Gerard; Wallace, Chris; Walters, G Bragi; Weedon, Michael ...; Witteman, Jacque ...; Zhang, Cuilin; Zhang, Weihua; Caulfield, Mark ...; Collins, Francis ...; Davey Smith, Geo ...; Day, Ian N M; Franks, Paul W; Hattersley, Andr ...; Hu, Frank B; Jarvelin, Marjo- ...; Kong, Augustine; Kooner, Jaspal S; Laakso, Markku; Lakatta, Edward; Mooser, Vincent; Morris, Andrew D; Peltonen, Leena; Samani, Nilesh J; Spector, Timothy ...; Strachan, David ...; Tanaka, Toshiko; Tuomilehto, Jaak ...; Uitterlinden, An ...; van Duijn, Corne ...; Wareham, Nichola ...; Waterworth, Dawn ...; Boehnke, Michael; Deloukas, Panos; Groop, Leif; Hunter, David J; Thorsteinsdottir ...; Schlessinger, Da ...; Wichmann, H-Eric ...; Frayling, Timoth ...; Abecasis, Gonçal ...; Hirschhorn, Joel ...; Loos, Ruth J F; Stefansson, Kari; Mohlke, Karen L; Barroso, Inês; McCarthy, Mark I; visa färre...

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