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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004425naa a2200361 4500
001oai:DiVA.org:umu-39670
003SwePub
008110203s2010 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-396702 URI
0247 a https://doi.org/10.1186/ar31162 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Södergren, Annau Umeå universitet,Reumatologi4 aut0 (Swepub:umu)anayxt97
2451 0a Atherosclerosis in early rheumatoid arthritis :b very early endothelial activation and rapid progression of intima media thickness
264 1b Springer Science and Business Media LLC,c 2010
338 a print2 rdacarrier
520 a INTRODUCTION : In this study we aimed to investigate whether there are indications of premature atherosclerosis, as measured by endothelial dependent flow-mediated dilation (ED-FMD) and intima media thickness (IMT), in patients with very early RA, and to analyze its relation to biomarkers of endothelial dysfunction, taking inflammation and traditional cardiovascular disease (CVD) risk factors into account. METHODS : Patients from the three northern counties of Sweden diagnosed with early RA are followed in an ongoing prospective study of CVD co-morbidity. Of these, all patients aged ≤60 years were consecutively included in this survey of CVD risk factors (n = 79). Forty-four age and sex matched controls were included. IMT of common carotid artery and ED-FMD of brachial artery were measured using ultrasonography. Blood was drawn for analysis of lipids, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA)-mass, VonWillebrand factor (VWF), soluble intercellular adhesion molecule-1 (sICAM), soluble vascular cell adhesion molecule-1 (sVCAM), sE-selectin, sL-selectin and monocyte chemotactic protein-1 (MCP-1). In a subgroup of 27 RA patients and their controls the ultrasound measurements were reanalysed after 18 months. RESULTS : There were no significant differences between RA patients and controls in terms of IMT or ED-FMD at the first evaluation. However after 18 months there was a significant increase in the IMT among the patients with RA (P < 0.05). Patients with RA had higher levels of VWF, sICAM-1 (P < 0.05) and of MCP-1 (P = 0.001) compared with controls. In RA, IMT was related to some of the traditional CVD risk factors, tPA-mass, VWF (P < 0.01) and MCP-1 and inversely to sL-selectin (P < 0.05). In RA, ED-FMD related to sL-selectin (P < 0.01). DAS28 at baseline was related to PAI-1, tPA-mass and inversely to sVCAM-1 (P < 0.05) and sL-selectin (P = 0.001). CONCLUSIONS : We found no signs of atherosclerosis in patients with newly diagnosed RA compared with controls. However, in patients with early RA, IMT and ED-FMD were, to a greater extent than in controls, related to biomarkers known to be associated with endothelial dysfunction and atherosclerosis. After 18 months, IMT had increased significantly in RA patients but not in controls.
7001 a Karp, Kjellu Umeå universitet,Klinisk fysiologi4 aut0 (Swepub:umu)kjka0001
7001 a Boman, Kurtu Department of Medicine, Skellefteå Hospital, Lasarettsvägen, Skellefteå4 aut0 (Swepub:umu)kubo0001
7001 a Eriksson, Catharina,d 1955-u Umeå universitet,Klinisk immunologi4 aut0 (Swepub:umu)caaern74
7001 a Lundström, Elisabetu Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap4 aut
7001 a Smedby, Torgnyu Department of Rheumatology, Östersund Hospital, Kyrkgatan, 831 83 Östersund, Sweden4 aut
7001 a Söderlund, Lisbetu Department of Rheumatology, Sunderby Hospital, 971 80 Luleå, Sweden4 aut
7001 a Rantapää-Dahlqvist, Solbrittu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sora0001
7001 a Wållberg-Jonsson, Solveigu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sowa0001
7102 a Umeå universitetb Reumatologi4 org
7730 t Arthritis Research & Therapyd : Springer Science and Business Media LLCg 12:4, s. R158-q 12:4<R158-x 1478-6362x 1478-6354
8564 u https://arthritis-research.biomedcentral.com/track/pdf/10.1186/ar3116
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-39670
8564 8u https://doi.org/10.1186/ar3116

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