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Randomized Controll...
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Cizmeci, Mehmet NUniversity of Toronto
(författare)
Randomized Controlled Early versus Late Ventricular Intervention Study in Posthemorrhagic Ventricular Dilatation : Outcome at 2 Years
- Artikel/kapitelEngelska2020
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Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:c32c7b66-4c20-4844-bede-a7f3fa848608
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https://lup.lub.lu.se/record/c32c7b66-4c20-4844-bede-a7f3fa848608URI
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https://doi.org/10.1016/j.jpeds.2020.08.014DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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OBJECTIVE: To compare the effect of intervention at low vs high threshold of ventriculomegaly in preterm infants with posthemorrhagic ventricular dilatation on death or severe neurodevelopmental disability.STUDY DESIGN: This multicenter randomized controlled trial reviewed lumbar punctures initiated after either a low threshold (ventricular index of >p97 and anterior horn width of >6 mm) or high threshold (ventricular index of >p97 + 4 mm and anterior horn width of >10 mm). The composite adverse outcome was defined as death or cerebral palsy or Bayley composite cognitive/motor scores <-2 SDs at 24 months corrected age.RESULTS: Outcomes were assessed in 113 of 126 infants. The composite adverse outcome was seen in 20 of 58 infants (35%) in the low threshold group and 28 of 55 (51%) in the high threshold (P = .07). The low threshold intervention was associated with a decreased risk of an adverse outcome after correcting for gestational age, severity of intraventricular hemorrhage, and cerebellar hemorrhage (aOR, 0.24; 95% CI, 0.07-0.87; P = .03). Infants with a favorable outcome had a smaller fronto-occipital horn ratio (crude mean difference, -0.06; 95% CI, -0.09 to -0.03; P < .001) at term-equivalent age. Infants in the low threshold group with a ventriculoperitoneal shunt, had cognitive and motor scores similar to those without (P = .3 for both), whereas in the high threshold group those with a ventriculoperitoneal shunt had significantly lower scores than those without a ventriculoperitoneal shunt (P = .01 and P = .004, respectively).CONCLUSIONS: In a post hoc analysis, earlier intervention was associated with a lower odds of death or severe neurodevelopmental disability in preterm infants with progressive posthemorrhagic ventricular dilatation.TRIAL REGISTRATION: ISRCTN43171322.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Groenendaal, FlorisErasmus University Medical Center
(författare)
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Liem, Kian DRadboud University Medical Center
(författare)
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van Haastert, Ingrid CErasmus University Medical Center
(författare)
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Benavente-Fernández, IsabelPuerta del Mar University Hospital
(författare)
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van Straaten, Henrica L MIsala Women and Children's Hospital
(författare)
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Steggerda, SylkeLeiden University Medical Centre
(författare)
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Smit, Bert JErasmus University Medical Center
(författare)
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Whitelaw, AndrewUniversity of Bristol
(författare)
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Woerdeman, PeterUniversity Medical Center Utrecht
(författare)
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Heep, AxelUniversity of Bristol
(författare)
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de Vries, Linda SErasmus University Medical Center
(författare)
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Ley, DavidLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups(Swepub:lu)pedi-dle
(creator_code:cre_t)
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Fellman, VinetaLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pedi-vfe
(creator_code:cre_t)
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University of TorontoErasmus University Medical Center
(creator_code:org_t)
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ELVIS study group
Sammanhörande titlar
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Ingår i:Journal of Pediatrics: Elsevier BV226, s. 3-351097-68330022-3476
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Cizmeci, Mehmet ...
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Groenendaal, Flo ...
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Liem, Kian D
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van Haastert, In ...
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Benavente-Fernán ...
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van Straaten, He ...
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visa fler...
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Steggerda, Sylke
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Smit, Bert J
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Whitelaw, Andrew
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Woerdeman, Peter
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Heep, Axel
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de Vries, Linda ...
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Ley, David
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Fellman, Vineta
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