WFRF:(Flodstrom Tullberg M)
Search: WFRF:(Flodstrom Tullberg M) > (2015-2019) > CFTR is involved in...
- 10 of 21
- Previous record
- Next record
- To hitlist
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04067naa a2200397 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:135533562 | |
| 003 | SwePub | |
| 008 | 240701s2017 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:71144849-e9c3-483e-b2dc-8a443867289d | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1355335622 URI |
| 024 | 7 | a https://doi.org/10.1038/s41598-017-00098-82 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/71144849-e9c3-483e-b2dc-8a443867289d2 URI |
| 040 | a (SwePub)kid (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Edlund, Annau Lund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups4 aut0 (Swepub:lu)med-aeu |
| 245 | 1 0 | a CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells |
| 264 | c 2017-03-07 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2017 |
| 520 | a Glucagon is the main counterregulatory hormone in the body. Still, the mechanism involved in the regulation of glucagon secretion from pancreatic alpha cells remains elusive. Dysregulated glucagon secretion is common in patients with Cystic Fibrosis (CF) that develop CF related diabetes (CFRD). CF is caused by a mutation in the Cl− channel Cystic fibrosis transmembrane conductance regulator (CFTR), but whether CFTR is present in human alpha cells and regulate glucagon secretion has not been investigated in detail. Here, both human and mouse alpha cells showed CFTR protein expression, whereas CFTR was absent in somatostatin secreting delta cells. CFTR-current activity induced by cAMP was measured in single alpha cells. Glucagon secretion at different glucose levels and in the presence of forskolin was increased by CFTR-inhibition in human islets, whereas depolarization-induced glucagon secretion was unaffected. CFTR is suggested to mainly regulate the membrane potential through an intrinsic alpha cell effect, as supported by a mathematical model of alpha cell electrophysiology. In conclusion, CFTR channels are present in alpha cells and act as important negative regulators of cAMP-enhanced glucagon secretion through effects on alpha cell membrane potential. Our data support that loss-of-function mutations in CFTR contributes to dysregulated glucagon secretion in CFRD. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 700 | 1 | a Pedersen, Morten Gramu University of Padova4 aut0 (Swepub:lu)med-meg |
| 700 | 1 | a Lindqvist, Andreasu Lund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups4 aut0 (Swepub:lu)medk-alt |
| 700 | 1 | a Wierup, Nilsu Lund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups4 aut0 (Swepub:lu)mphy-nwi |
| 700 | 1 | a Flodstrom-Tullberg, Mu Karolinska Institute,Karolinska Institutet4 aut |
| 700 | 1 | a Eliasson, Lenau Lund University,Lunds universitet,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Diabetes - Islet Cell Exocytosis,Lund University Research Groups4 aut0 (Swepub:lu)mphy-lel |
| 710 | 2 | a Diabetes - öcellsexocytosb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Scientific reportsd : Springer Science and Business Media LLCg 7:1, s. 90-q 7:1<90-x 2045-2322 |
| 856 | 4 | u https://www.nature.com/articles/s41598-017-00098-8.pdf |
| 856 | 4 | u http://dx.doi.org/10.1038/s41598-017-00098-8x freey FULLTEXT |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:135533562 |
| 856 | 4 8 | u https://doi.org/10.1038/s41598-017-00098-8 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/71144849-e9c3-483e-b2dc-8a443867289d |
Find in a library
- Scientific reports (Search for host publication in LIBRIS)
To the university's database
- 10 of 21
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Edlund, Anna
- Pedersen, Morten ...
- Lindqvist, Andre ...
- Wierup, Nils
- Flodstrom-Tullbe ...
- Eliasson, Lena
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Endocrinology an ...
- Articles in the publication
- Scientific repor ...
- By the university
- Karolinska Institutet
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
