Sökning: WFRF:(Freimer Nelson A.) > Genome-wide associa...
Fältnamn | Indikatorer | Metadata |
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000 | 07149naa a2201717 4500 | |
001 | oai:DiVA.org:uu-153554 | |
003 | SwePub | |
008 | 110516s2011 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1535542 URI |
024 | 7 | a https://doi.org/10.1073/pnas.10172881082 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Schumann, Gunter4 aut |
245 | 1 0 | a Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption |
264 | c 2011-04-06 | |
264 | 1 | b Proceedings of the National Academy of Sciences,c 2011 |
338 | a print2 rdacarrier | |
520 | a Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of similar to 2.5 million directly genotyped or imputed SNPs with alcohol consumption (gram per day per kilogram body weight) among 12 population-based samples of European ancestry, comprising 26,316 individuals, with replication genotyping in an additional 21,185 individuals. SNP rs6943555 in autism susceptibility candidate 2 gene (AUTS2) was associated with alcohol consumption at genome-wide significance (P = 4 x 10(-8) to P = 4 x 10(-9)). We found a genotype-specific expression of AUTS2 in 96 human prefrontal cortex samples (P = 0.026) and significant (P < 0.017) differences in expression of AUTS2 in whole-brain extracts of mice selected for differences in voluntary alcohol consumption. Downregulation of an AUTS2 homolog caused reduced alcohol sensitivity in Drosophila (P < 0.001). Our finding of a regulator of alcohol consumption adds knowledge to our understanding of genetic mechanisms influencing alcohol drinking behavior. | |
653 | a genome-wide analysis | |
653 | a epidemiologic | |
653 | a transcriptional expression analysis | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Coin, Lachlan J.4 aut |
700 | 1 | a Lourdusamy, Anbarasu4 aut |
700 | 1 | a Charoen, Pimphen4 aut |
700 | 1 | a Berger, Karen H.4 aut |
700 | 1 | a Stacey, David4 aut |
700 | 1 | a Desrivieres, Sylvane4 aut |
700 | 1 | a Aliev, Fazil A.4 aut |
700 | 1 | a Khan, Anokhi A.4 aut |
700 | 1 | a Amin, Najaf4 aut |
700 | 1 | a Aulchenko, Yurii S.4 aut |
700 | 1 | a Bakalkin, Georgyu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)gueba200 |
700 | 1 | a Bakker, Stephan J.4 aut |
700 | 1 | a Balkau, Beverley4 aut |
700 | 1 | a Beulens, Joline W.4 aut |
700 | 1 | a Bilbao, Ainhoa4 aut |
700 | 1 | a de Boer, Rudolf A.4 aut |
700 | 1 | a Beury, Delphine4 aut |
700 | 1 | a Bots, Michiel L.4 aut |
700 | 1 | a Breetvelt, Elemi J.4 aut |
700 | 1 | a Cauchi, Stephane4 aut |
700 | 1 | a Cavalcanti-Proenca, Christine4 aut |
700 | 1 | a Chambers, John C.4 aut |
700 | 1 | a Clarke, Toni-Kim4 aut |
700 | 1 | a Dahmen, Norbert4 aut |
700 | 1 | a de Geus, Eco J.4 aut |
700 | 1 | a Dick, Danielle4 aut |
700 | 1 | a Ducci, Francesca4 aut |
700 | 1 | a Easton, Alanna4 aut |
700 | 1 | a Edenberg, Howard J.4 aut |
700 | 1 | a Esk, Tonu4 aut |
700 | 1 | a Fernandez-Medarde, Alberto4 aut |
700 | 1 | a Foroud, Tatiana4 aut |
700 | 1 | a Freimer, Nelson B.4 aut |
700 | 1 | a Girault, Jean-Antoine4 aut |
700 | 1 | a Grobbee, Diederick E.4 aut |
700 | 1 | a Guarrera, Simonetta4 aut |
700 | 1 | a Gudbjartsson, Daniel F.4 aut |
700 | 1 | a Hartikainen, Anna-Liisa4 aut |
700 | 1 | a Heath, Andrew C.4 aut |
700 | 1 | a Hesselbrock, Victor4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Hottenga, Jouke-Jan4 aut |
700 | 1 | a Isohanni, Matti K.4 aut |
700 | 1 | a Kaprio, Jaakko4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Kuehnel, Brigitte4 aut |
700 | 1 | a Laitinen, Jaana4 aut |
700 | 1 | a Lobbens, Stephane4 aut |
700 | 1 | a Luan, Jian'an4 aut |
700 | 1 | a Mangino, Massimo4 aut |
700 | 1 | a Maroteaux, Matthieu4 aut |
700 | 1 | a Matullo, Giuseppe4 aut |
700 | 1 | a McCarthy, Mark I.4 aut |
700 | 1 | a Mueller, Christian4 aut |
700 | 1 | a Navis, Gerjan4 aut |
700 | 1 | a Numans, Mattijs E.4 aut |
700 | 1 | a Nunez, Alejandro4 aut |
700 | 1 | a Nyholt, Dale R.4 aut |
700 | 1 | a Onland-Moret, Charlotte N.4 aut |
700 | 1 | a Oostra, Ben A.4 aut |
700 | 1 | a O'Reilly, Paul F.4 aut |
700 | 1 | a Palkovits, Miklos4 aut |
700 | 1 | a Penninx, Brenda W.4 aut |
700 | 1 | a Polidoro, Silvia4 aut |
700 | 1 | a Pouta, Anneli4 aut |
700 | 1 | a Prokopenko, Inga4 aut |
700 | 1 | a Ricceri, Fulvio4 aut |
700 | 1 | a Santos, Eugenio4 aut |
700 | 1 | a Smit, Johannes H.4 aut |
700 | 1 | a Soranzo, Nicole4 aut |
700 | 1 | a Song, Kijoung4 aut |
700 | 1 | a Sovio, Ulla4 aut |
700 | 1 | a Stumvoll, Michael4 aut |
700 | 1 | a Surakk, Ida4 aut |
700 | 1 | a Thorgeirsson, Thorgeir E.4 aut |
700 | 1 | a Thorsteinsdottir, Unnur4 aut |
700 | 1 | a Troakes, Claire4 aut |
700 | 1 | a Tyrfingsson, Thorarinn4 aut |
700 | 1 | a Toenjes, Anke4 aut |
700 | 1 | a Uiterwaal, Cuno S.4 aut |
700 | 1 | a Uitterlinden, Andre G.4 aut |
700 | 1 | a van der Harst, Pim4 aut |
700 | 1 | a van der Schouw, Yvonne T.4 aut |
700 | 1 | a Staehlin, Oliver4 aut |
700 | 1 | a Vogelzangs, Nicole4 aut |
700 | 1 | a Vollenweider, Peter4 aut |
700 | 1 | a Waeber, Gerard4 aut |
700 | 1 | a Wareham, Nicholas J.4 aut |
700 | 1 | a Waterworth, Dawn M.4 aut |
700 | 1 | a Whitfield, John B.4 aut |
700 | 1 | a Wichmann, Erich H.4 aut |
700 | 1 | a Willemsen, Gonneke4 aut |
700 | 1 | a Witteman, Jacqueline C.4 aut |
700 | 1 | a Yuan, Xin4 aut |
700 | 1 | a Zhai, Guangju4 aut |
700 | 1 | a Zhao, Jing H.4 aut |
700 | 1 | a Zhang, Weihua4 aut |
700 | 1 | a Martin, Nicholas G.4 aut |
700 | 1 | a Metspalu, Andres4 aut |
700 | 1 | a Doering, Angela4 aut |
700 | 1 | a Scott, James4 aut |
700 | 1 | a Spector, Tim D.4 aut |
700 | 1 | a Loos, Ruth J.4 aut |
700 | 1 | a Boomsma, Dorret I.4 aut |
700 | 1 | a Mooser, Vincent4 aut |
700 | 1 | a Peltonen, Leena4 aut |
700 | 1 | a Stefansson, Kari4 aut |
700 | 1 | a van Duijn, Cornelia M.4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Sommer, Wolfgang H.4 aut |
700 | 1 | a Kooner, Jaspal S.4 aut |
700 | 1 | a Spanagel, Rainer4 aut |
700 | 1 | a Heberlein, Ulrike A.4 aut |
700 | 1 | a Jarvelin, Marjo-Riitta4 aut |
700 | 1 | a Elliott, Paul4 aut |
710 | 2 | a Uppsala universitetb Institutionen för farmaceutisk biovetenskap4 org |
773 | 0 | t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 108:17, s. 7119-7124q 108:17<7119-7124x 0027-8424x 1091-6490 |
856 | 4 | u http://www.pnas.org/content/108/17/7119.full.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-153554 |
856 | 4 8 | u https://doi.org/10.1073/pnas.1017288108 |
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