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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004636naa a2200697 4500
001oai:DiVA.org:umu-171345
003SwePub
008200608s2020 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1713452 URI
0247 a https://doi.org/10.1186/s13075-020-02178-z2 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Wibetoe, Grunde4 aut
2451 0a Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations :b evaluation of concordance across risk age models
264 c 2020-04-23
264 1b Springer Nature,c 2020
338 a electronic2 rdacarrier
520 a Background: In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk estimation in European guidelines. We aimed to compare the discriminative ability of available risk age models in prediction of CVD in rheumatoid arthritis (RA). Secondly, we also evaluated the performance of risk age models in subgroups based on RA disease characteristics.Methods: RA patients aged 30–70 years were included from an international consortium named A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA). Prior CVD and diabetes mellitus were exclusion criteria. The discriminatory ability of specific risk age models was evaluated using c-statistics and their standard errors after calculating time until fatal or non-fatal CVD or last follow-up.Results: A total of 1974 patients were included in the main analyses, and 144 events were observed during follow-up, the median follow-up being 5.0 years. The risk age models gave highly correlated results, demonstrating R2 values ranging from 0.87 to 0.97. However, risk age estimations differed > 5 years in 15–32% of patients. C-statistics ranged 0.68–0.72 with standard errors of approximately 0.03. Despite certain RA characteristics being associated with low c-indices, standard errors were high. Restricting analysis to European RA patients yielded similar results.Conclusions: The cardiovascular risk age and vascular age models have comparable performance in predicting CVD in RA patients. The influence of RA disease characteristics on the predictive ability of these prediction models remains inconclusive.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653 a Cardiovascular risk age
653 a Vascular age
653 a Cardiovascular disease
653 a Risk factors
653 a Rheumatoid arthritis
7001 a Sexton, Joseph4 aut
7001 a Ikdahl, Eirik4 aut
7001 a Rollefstad, Silvia4 aut
7001 a Kitas, George D.4 aut
7001 a van Riel, Piet4 aut
7001 a Gabriel, Sherine4 aut
7001 a Kvien, Tore K.4 aut
7001 a Douglas, Karen4 aut
7001 a Sandoo, Aamer4 aut
7001 a Arts, Elke E.4 aut
7001 a Wållberg-Jonsson, Solveig,d 1953-u Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sowa0001
7001 a Rantapää-Dahlqvist, Solbrittu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sora0001
7001 a Karpouzas, George4 aut
7001 a Dessein, Patrick H.4 aut
7001 a Tsang, Linda4 aut
7001 a El-Gabalawy, Hani4 aut
7001 a Hitchon, Carol A.4 aut
7001 a Pascual-Ramos, Virginia4 aut
7001 a Contreas-Yanes, Irazu4 aut
7001 a Sfikakis, Petros P.4 aut
7001 a Gonzalez-Gay, Miguel A.4 aut
7001 a Colunga-Pedraz, Iris J.4 aut
7001 a Galarza-Delgado, Dionicio A.4 aut
7001 a Azpiri-Lopez, Jose Ramon4 aut
7001 a Crowson, Cynthia S.4 aut
7001 a Semb, Anne Grete4 aut
7102 a Umeå universitetb Reumatologi4 org
7730 t Arthritis Research & Therapyd : Springer Natureg 22:1q 22:1x 1478-6354x 1478-6362
8564 u https://doi.org/10.1186/s13075-020-02178-zy Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1436440/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://arthritis-research.biomedcentral.com/track/pdf/10.1186/s13075-020-02178-z
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-171345
8564 8u https://doi.org/10.1186/s13075-020-02178-z

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