Sökning: WFRF:(Goode Ellen L) > Heterogeneity of br...
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000 | 08165naa a2201693 4500 | |
001 | oai:DiVA.org:uu-105393 | |
003 | SwePub | |
008 | 090603s2008 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:116961299 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1053932 URI |
024 | 7 | a https://doi.org/10.1371/journal.pgen.10000542 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1169612992 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Garcia-Closas, Montserrat4 aut |
245 | 1 0 | a Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics |
264 | c 2008-04-25 | |
264 | 1 | b Public Library of Science (PLoS),c 2008 |
338 | a print2 rdacarrier | |
520 | a A three-stage genome-wide association study recently identified single nucleotide polymorphisms (SNPs) in five loci (fibroblast growth receptor 2 (FGFR2), trinucleotide repeat containing 9 (TNRC9), mitogen-activated protein kinase 3 K1 (MAP3K1), 8q24, and lymphocyte-specific protein 1 (LSP1)) associated with breast cancer risk. We investigated whether the associations between these SNPs and breast cancer risk varied by clinically important tumor characteristics in up to 23,039 invasive breast cancer cases and 26,273 controls from 20 studies. We also evaluated their influence on overall survival in 13,527 cases from 13 studies. All participants were of European or Asian origin. rs2981582 in FGFR2 was more strongly related to ER-positive (per-allele OR (95%CI) = 1.31 (1.27-1.36)) than ER-negative (1.08 (1.03-1.14)) disease (P for heterogeneity = 10(-13)). This SNP was also more strongly related to PR-positive, low grade and node positive tumors (P = 10(-5), 10(-8), 0.013, respectively). The association for rs13281615 in 8q24 was stronger for ER-positive, PR-positive, and low grade tumors (P = 0.001, 0.011 and 10(-4), respectively). The differences in the associations between SNPs in FGFR2 and 8q24 and risk by ER and grade remained significant after permutation adjustment for multiple comparisons and after adjustment for other tumor characteristics. Three SNPs (rs2981582, rs3803662, and rs889312) showed weak but significant associations with ER-negative disease, the strongest association being for rs3803662 in TNRC9 (1.14 (1.09-1.21)). rs13281615 in 8q24 was associated with an improvement in survival after diagnosis (per-allele HR = 0.90 (0.83-0.97). The association was attenuated and non-significant after adjusting for known prognostic factors. Our findings show that common genetic variants influence the pathological subtype of breast cancer and provide further support for the hypothesis that ER-positive and ER-negative disease are biologically distinct. Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment. | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Hall, Peru Karolinska Institutet4 aut |
700 | 1 | a Nevanlinna, Heli4 aut |
700 | 1 | a Pooley, Karen4 aut |
700 | 1 | a Morrison, Jonathan4 aut |
700 | 1 | a Richesson, Douglas A.4 aut |
700 | 1 | a Bojesen, Stig E.4 aut |
700 | 1 | a Nordestgaard, Børge G.4 aut |
700 | 1 | a Axelsson, Christen K.4 aut |
700 | 1 | a Arias, Jose I.4 aut |
700 | 1 | a Milne, Roger L.4 aut |
700 | 1 | a Ribas, Gloria4 aut |
700 | 1 | a González-Neira, Anna4 aut |
700 | 1 | a Benítez, Javier4 aut |
700 | 1 | a Zamora, Pilar4 aut |
700 | 1 | a Brauch, Hiltrud4 aut |
700 | 1 | a Justenhoven, Christina4 aut |
700 | 1 | a Hamann, Ute4 aut |
700 | 1 | a Ko, Yon-Dschun4 aut |
700 | 1 | a Bruening, Thomas4 aut |
700 | 1 | a Haas, Susanne4 aut |
700 | 1 | a Dörk, Thilo4 aut |
700 | 1 | a Schürmann, Peter4 aut |
700 | 1 | a Hillemanns, Peter4 aut |
700 | 1 | a Bogdanova, Natalia4 aut |
700 | 1 | a Bremer, Michael4 aut |
700 | 1 | a Karstens, Johann Hinrich4 aut |
700 | 1 | a Fagerholm, Rainer4 aut |
700 | 1 | a Aaltonen, Kirsimari4 aut |
700 | 1 | a Aittomäki, Kristiina4 aut |
700 | 1 | a von Smitten, Karl4 aut |
700 | 1 | a Blomqvist, Carlu Uppsala universitet,Enheten för onkologi4 aut |
700 | 1 | a Mannermaa, Arto4 aut |
700 | 1 | a Uusitupa, Matti4 aut |
700 | 1 | a Eskelinen, Matti4 aut |
700 | 1 | a Tengström, Maria4 aut |
700 | 1 | a Kosma, Veli-Matti4 aut |
700 | 1 | a Kataja, Vesa4 aut |
700 | 1 | a Chenevix-Trench, Georgia4 aut |
700 | 1 | a Spurdle, Amanda B.4 aut |
700 | 1 | a Beesley, Jonathan4 aut |
700 | 1 | a Chen, Xiaoqing4 aut |
700 | 1 | a Australian Ovarian Cancer Management Group,4 aut |
700 | 1 | a Kathleen Cuningham Foundation Consortium For Research Into Familial Breast Cancer,4 aut |
700 | 1 | a Devilee, Peter4 aut |
700 | 1 | a van Asperen, Christi J.4 aut |
700 | 1 | a Jacobi, Catharina E.4 aut |
700 | 1 | a Tollenaar, Rob A. E. M.4 aut |
700 | 1 | a Huijts, Petra E. A.4 aut |
700 | 1 | a Klijn, Jan G. M.4 aut |
700 | 1 | a Chang-Claude, Jenny4 aut |
700 | 1 | a Kropp, Silke4 aut |
700 | 1 | a Slanger, Tracy4 aut |
700 | 1 | a Flesch-Janys, Dieter4 aut |
700 | 1 | a Mutschelknauss, Elke4 aut |
700 | 1 | a Salazar, Ramona4 aut |
700 | 1 | a Wang-Gohrke, Shan4 aut |
700 | 1 | a Couch, Fergus4 aut |
700 | 1 | a Goode, Ellen L.4 aut |
700 | 1 | a Olson, Janet E.4 aut |
700 | 1 | a Vachon, Celine4 aut |
700 | 1 | a Fredericksen, Zachary S.4 aut |
700 | 1 | a Giles, Graham G.4 aut |
700 | 1 | a Baglietto, Laura4 aut |
700 | 1 | a Severi, Gianluca4 aut |
700 | 1 | a Hopper, John L.4 aut |
700 | 1 | a English, Dallas R.4 aut |
700 | 1 | a Southey, Melissa C.4 aut |
700 | 1 | a Haiman, Christopher A.4 aut |
700 | 1 | a Henderson, Brian E.4 aut |
700 | 1 | a Kolonel, Laurence N.4 aut |
700 | 1 | a Le Marchand, Loic4 aut |
700 | 1 | a Stram, Daniel O.4 aut |
700 | 1 | a Hunter, David J.4 aut |
700 | 1 | a Hankinson, Susan E.4 aut |
700 | 1 | a Cox, David G.4 aut |
700 | 1 | a Tamimi, Rulla4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Sherman, Mark E.4 aut |
700 | 1 | a Chanock, Stephen J.4 aut |
700 | 1 | a Lissowska, Jolanta4 aut |
700 | 1 | a Brinton, Louise A.4 aut |
700 | 1 | a Peplonska, Beata4 aut |
700 | 1 | a Klijn, Jan G. M.4 aut |
700 | 1 | a Hooning, Maartje J.4 aut |
700 | 1 | a Meijers-Heijboer, Han4 aut |
700 | 1 | a Collee, J. Margriet4 aut |
700 | 1 | a van den Ouweland, Ans4 aut |
700 | 1 | a Uitterlinden, Andre G.4 aut |
700 | 1 | a Liu, Jianjun4 aut |
700 | 1 | a Lin, Low Yen4 aut |
700 | 1 | a Yuqing, Li4 aut |
700 | 1 | a Humphreys, Keithu Karolinska Institutet4 aut |
700 | 1 | a Czene, Kamilau Karolinska Institutet4 aut |
700 | 1 | a Cox, Angela4 aut |
700 | 1 | a Balasubramanian, Sabapathy P.4 aut |
700 | 1 | a Cross, Simon S.4 aut |
700 | 1 | a Reed, Malcolm W. R.4 aut |
700 | 1 | a Blows, Fiona4 aut |
700 | 1 | a Driver, Kristy4 aut |
700 | 1 | a Dunning, Alison4 aut |
700 | 1 | a Tyrer, Jonathan4 aut |
700 | 1 | a Ponder, Bruce A. J.4 aut |
700 | 1 | a Sangrajrang, Suleeporn4 aut |
700 | 1 | a Brennan, Paul4 aut |
700 | 1 | a McKay, James4 aut |
700 | 1 | a Odefrey, Fabrice4 aut |
700 | 1 | a Gabrieau, Valerie4 aut |
700 | 1 | a Sigurdson, Alice4 aut |
700 | 1 | a Doody, Michele4 aut |
700 | 1 | a Struewing, Jeffrey P.4 aut |
700 | 1 | a Alexander, Bruce4 aut |
700 | 1 | a Easton, Douglas F.4 aut |
700 | 1 | a Pharoah, Paul D.4 aut |
710 | 2 | a Karolinska Institutetb Enheten för onkologi4 org |
773 | 0 | t PLoS geneticsd : Public Library of Science (PLoS)g 4:4, s. e1000054-q 4:4<e1000054-x 1553-7404 |
856 | 4 | u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000054&type=printable |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105393 |
856 | 4 8 | u https://doi.org/10.1371/journal.pgen.1000054 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:116961299 |
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