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Personalized microb...
Personalized microbial fingerprint associated with differential glycemic effects of a whole grain rye intervention on Chinese adults
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- Li, Wenyun (författare)
- School of Public Health Fudan University/Key Laboratory of Public Health Safety Ministry of Education Shanghai 200032 China,Fudan University
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- Tang, Huiru (författare)
- State Key Laboratory of Genetic Engineering Zhongshan Hospital and School of Life Sciences Laboratory of Metabonomics and Systems Biology Human Phenome Institute Fudan University Shanghai 200032 China,Fudan University
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- Xue, Kun (författare)
- School of Public Health Fudan University/Key Laboratory of Public Health Safety Ministry of Education Shanghai 200032 China,Fudan University
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- Ying, Tao (författare)
- School of Public Health Fudan University/Key Laboratory of Public Health Safety Ministry of Education Shanghai 200032 China,Fudan University
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- Wu, Min (författare)
- School of Public Health Fudan University/Key Laboratory of Public Health Safety Ministry of Education Shanghai 200032 China,Fudan University
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- Qu, Zheng (författare)
- Department of Gastroenterology Zhongye Hospital Shanghai 200003 China
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- Dong, Chenglin (författare)
- Department of Clinical Laboratory Zhongye Hospital Shanghai 200003 China
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- Jin, Taiyi (författare)
- School of Public Health Fudan University/Key Laboratory of Public Health Safety Ministry of Education Shanghai 200032 China,Fudan University
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- Brunius, Carl, 1974 (författare)
- Department of Life Sciences Chalmers University of Technology Gothenburg 412 96 Sweden,Chalmers tekniska högskola,Chalmers University of Technology
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- Hallmans, Göran, 1947- (författare)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Umeå University
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- Åman, Per (författare)
- Department of Molecular Sciences Swedish University of Agricultural Sciences Uppsala 750 07 Sweden,Sveriges lantbruksuniversitet (SLU),Swedish University of Agricultural Sciences (SLU)
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- Johansson, Anders, 1955- (författare)
- Umeå universitet,Institutionen för odontologi,Aa gruppen,Umeå University
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- Landberg, Rikard, 1981 (författare)
- Department of Life Sciences Chalmers University of Technology Gothenburg 412 96 Sweden,Chalmers tekniska högskola,Chalmers University of Technology
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- Liu, Yuwei (författare)
- School of Public Health Fudan University/Key Laboratory of Public Health Safety Ministry of Education Shanghai 200032 China,Fudan University
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- He, Gengsheng (författare)
- School of Public Health Fudan University/Key Laboratory of Public Health Safety Ministry of Education Shanghai 200032 China,Fudan University
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Molecular Nutrition & Food Research. - : John Wiley & Sons. - 1613-4125 .- 1613-4133.
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- Scope: This study aims to identify the gut enterotypes that explain differential responses to intervention with whole grain rye by proposing an “enterotype - metabolic” model.Methods and results: A 12-week randomized controlled trial is conducted in Chinese adults, with 79 subjects consuming whole grain products with fermented rye bran (FRB) and 77 consuming refined wheat products in this exploratory post-hoc analysis. Responders or non-responders are identified according to whether blood glucose decreased by more than 10% after rye intervention. Compared to non-responders, responders in FRB have higher baseline Bacteroides (p < 0.001), associated with reduced blood glucose (p < 0.001), increased Faecalibacterium (p = 0.020) and Erysipelotrichaceae_UCG.003 (p = 0.022), as well as deceased 7β-hydroxysteroid dehydrogenase (p = 0.033) after intervention. The differentiated gut microbiota and metabolites between responders and non-responders after intervention are enriched in aminoacyl-tRNA biosynthesis.Conclusion: The work confirms the previously suggested importance of microbial enterotypes in differential responses to whole grain interventions and supports taking enterotypes into consideration for improved efficacy of whole grain intervention for preventing type 2 diabetes. Altered short-chain fatty acids and bile acid metabolism might be a potential mediator for the beneficial effects of whole grain rye on glucose metabolism.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Livsmedelsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Food Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Whole grain rye
- gut microbiota
- bile acid
- glycemic effect
- mikrobiologi
- Microbiology
- Nutrition
- näringslära
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Li, Wenyun
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Tang, Huiru
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Xue, Kun
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Ying, Tao
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Wu, Min
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Qu, Zheng
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Dong, Chenglin
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Jin, Taiyi
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Brunius, Carl, 1 ...
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Hallmans, Göran, ...
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Åman, Per
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Johansson, Ander ...
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Landberg, Rikard ...
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Liu, Yuwei
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He, Gengsheng
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
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- LANTBRUKSVETENSKAPER
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LANTBRUKSVETENSK ...
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och Lantbruksvetensk ...
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och Livsmedelsvetens ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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Molecular Nutrit ...
- Av lärosätet
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Umeå universitet
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Chalmers tekniska högskola