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Reduced-intensity t...
Reduced-intensity transplantation for lymphomas using haploidentical related donors vs HLA-matched unrelated donors
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- Kanate, Abraham S. (författare)
- W Virginia Univ, Osborn Hematopoiet Malignancy & Transplantat Prog, Morgantown, WV 26506 USA.
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- Mussetti, Alberto (författare)
- Ist Nazl Tumori, Fdn Ist Ricovero & Cura Carattere Sci, SC Ematol & Trapianto Midollo Osseo, Via Venezian 1, I-20133 Milan, Italy.
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- Kharfan-Dabaja, Mohamed A. (författare)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA.
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- Ahn, Kwang W. (författare)
- Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Dept Med, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA.
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- DiGilio, Alyssa (författare)
- Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Dept Med, Milwaukee, WI 53226 USA.
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- Beitinjaneh, Amer (författare)
- Emily Couric Clin Canc Ctr, Div Hematol Oncol, Dept Med, Charlottesville, VA USA.
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- Chhabra, Saurabh (författare)
- Med Univ S Carolina, Div Hematol Oncol, Charleston, SC 29425 USA.
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- Fenske, Timothy S. (författare)
- Med Coll Wisconsin, Froedtert Mem Lutheran Hosp, Dept Hematol Oncol, Milwaukee, WI 53226 USA.
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- Freytes, Cesar (författare)
- South Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA.;Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
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- Gale, Robert Peter (författare)
- Univ London Imperial Coll Sci Technol & Med, Dept Med, Hematol Res Ctr, Div Expt Med, London, England.
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- Ganguly, Siddhartha (författare)
- Univ Kansas, Med Ctr, Blood & Marrow Transplantat, Div Hematol & Oncol, Kansas City, KS 66103 USA.
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- Hertzberg, Mark (författare)
- Prince Wales Hosp, Dept Haematol, Randwick, NSW 2031, Australia.
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- Klyuchnikov, Evgeny (författare)
- Univ Canc Ctr, Dept Stem Cell Transplantat, Hamburg, Germany.
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- Lazarus, Hillard M. (författare)
- Univ Hosp, Case Med Ctr, Seidman Canc Ctr, Cleveland, OH USA.
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- Olsson, Richard (författare)
- Karolinska Institutet,Uppsala universitet,Hematologi,Karolinska Inst, Dept Lab Med, Div Therapeut Immunol, Stockholm, Sweden.
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- Perales, Miguel-Angel (författare)
- Mem Sloan Kettering Canc Ctr, Adult Marrow Transplantat Serv, Dept Med, 1275 York Ave, New York, NY 10021 USA.
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- Rezvani, Andrew (författare)
- Stanford Univ, Med Ctr, Blood & Marrow Transplantat, Stanford, CA 94305 USA.
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- Riches, Marcie (författare)
- Univ N Carolina, Div Hematol Oncol, Chapel Hill, NC USA.
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- Saad, Ayman (författare)
- Univ Alabama Birmingham, Dept Med, Div Hematol Oncol, Birmingham, AL 35294 USA.
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- Slavin, Shimon (författare)
- Int Ctr Cell Therapy & Canc Immunotherapy, Tel Aviv, Israel.
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- Smith, Sonali M. (författare)
- Univ Chicago, Hematol Oncol Sect, Chicago, IL 60637 USA.
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- Sureda, Anna (författare)
- Hosp Duran I Reynals, Inst Catala Oncol, Serv Hematol, Barcelona, Spain.
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- Yared, Jean (författare)
- Univ Maryland, Greenebaum Canc Ctr, Blood & Marrow Transplantat Program, Div Hematol Oncol,Dept Med, Baltimore, MD 21201 USA.
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- Ciurea, Stefan (författare)
- Univ Texas Houston, MD Anderson Canc Ctr, Dept Hematol, 1515 Holcombe Blvd, Houston, TX 77030 USA.
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- Armand, Philippe (författare)
- Dana Farber Canc Inst, Dept Med Oncol Hematol Malignancies, Boston, MA 02115 USA.
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- Salit, Rachel (författare)
- Fred Hutchinson Canc Res Ctr, Dept Hematol Oncol, 1124 Columbia St, Seattle, WA 98104 USA.
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- Bolanos-Meade, Javier (författare)
- Johns Hopkins Univ, Sidney Kimmel Canc Ctr, Div Hematol Malignancies, Baltimore, MD USA.
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- Hamadani, Mehdi (författare)
- Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Dept Med, Milwaukee, WI 53226 USA.
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W Virginia Univ, Osborn Hematopoiet Malignancy & Transplantat Prog, Morgantown, WV 26506 USA Ist Nazl Tumori, Fdn Ist Ricovero & Cura Carattere Sci, SC Ematol & Trapianto Midollo Osseo, Via Venezian 1, I-20133 Milan, Italy. (creator_code:org_t)
- American Society of Hematology, 2016
- 2016
- Engelska.
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 127:7, s. 938-947
- Relaterad länk:
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https://ashpublicati...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- We evaluated 917 adult lymphoma patients who received haploidentical (n = 185) or HLA-matched unrelated donor (URD) transplantation either with (n = 241) or without antithymocyte globulin (ATG; n = 491) following reduced-intensity conditioning regimens. Haploidentical recipients received posttransplant cyclophosphamide-based graft-versus-host disease (GVHD) prophylaxis, whereas URD recipients received calcineurin inhibitor-based prophylaxis. Median follow-up of survivors was 3 years. The 100-day cumulative incidence of grade III-IV acute GVHD on univariate analysis was 8%, 12%, and 17% in the haploidentical, URD without ATG, and URD with ATG groups, respectively (P = .44). Corresponding 1-year rates of chronic GVHD on univariate analysis were 13%, 51%, and 33%, respectively (P < .001). On multivariate analysis, grade III-IV acute GVHD was higher in URD without ATG (P = .001), as well as URD with ATG (P = .01), relative to haploidentical transplants. Similarly, relative to haploidentical transplants, risk of chronic GVHD was higher in URD without ATG and URD with ATG (P < .0001). Cumulative incidence of relapse/progression at 3 years was 36%, 28%, and 36% in the haploidentical, URD without ATG, and URD with ATG groups, respectively (P = .07). Corresponding 3-year overall survival (OS) was 60%, 62%, and 50% in the 3 groups, respectively, with multivariate analysis showing no survival difference between URD without ATG (P = .21) or URD with ATG (P = .16), relative to haploidentical transplants. Multivariate analysis showed no difference between the 3 groups in terms of nonrelapse mortality (NRM), relapse/progression, and progression-free survival (PFS). These data suggest that reduced-intensity conditioning haploidentical transplantation with posttransplant cyclophosphamide does not compromise early survival outcomes compared with matched URD transplantation, and is associated with significantly reduced risk of chronic GVHD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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- Av författaren/redakt...
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Kanate, Abraham ...
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Mussetti, Albert ...
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Kharfan-Dabaja, ...
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Ahn, Kwang W.
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DiGilio, Alyssa
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Beitinjaneh, Ame ...
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visa fler...
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Chhabra, Saurabh
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Fenske, Timothy ...
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Freytes, Cesar
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Gale, Robert Pet ...
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Ganguly, Siddhar ...
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Hertzberg, Mark
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Klyuchnikov, Evg ...
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Lazarus, Hillard ...
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Olsson, Richard
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Perales, Miguel- ...
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Rezvani, Andrew
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Riches, Marcie
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Saad, Ayman
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Slavin, Shimon
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Smith, Sonali M.
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Sureda, Anna
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Yared, Jean
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Ciurea, Stefan
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Armand, Philippe
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Salit, Rachel
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Bolanos-Meade, J ...
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Hamadani, Mehdi
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Uppsala universitet
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Karolinska Institutet