WFRF:(Han Ting)
Sökning: WFRF:(Han Ting) > (2015-2019) > Protein-bound uremi...
- 10 av 10
- Föregående post
- Nästa post
- Till träfflistan
Protein-bound uremic toxins are associated with cognitive function among patients undergoing maintenance hemodialysis
-
- Yi-Ting, Lin (författare)
- Uppsala universitet,Molekylär epidemiologi,Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan;Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung, Taiwan
-
- Wu, Ping-Hsun (författare)
- Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan;Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan
-
- Liang, Shih-Shin (författare)
- Kaohsiung Med Univ, Coll Life Sci, Dept Biotechnol, Kaohsiung, Taiwan
- visa fler...
- visa färre...
- (creator_code:org_t)
- 2019-12-31
- 2019
- Engelska.
- Ingår i: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 9
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Patients with chronic kidney disease have a greater risk of cognitive impairment. Cerebral uremic solute accumulation causes uremic encephalopathy; however, the association of protein-bound uremic toxins on cognitive function remains unclear. The present study aimed to investigate the association of two protein-bound uremic toxins, namely indoxyl sulfate (IS) and p-cresyl sulfate (PCS), on cognitive function in patients receiving hemodialysis (HD) for at least 90 days. Circulating free form IS and PCS were quantified by liquid chromatography/mass spectrometry. Mini-Mental State Examination (MMSE) and Cognitive Abilities Screening Instrument (CASI) were used to evaluate cognitive function. In total, 260 HD patients were recruited with a mean age of 58.1 +/- 11.3 years, of which, 53.8% were men, 40% had diabetes, and 75.4% had hypertension. The analysis revealed that both free IS and free PCS were negatively associated with the CASI score and MMSE. After controlling for confounders, circulating free IS levels persisted to be negatively associated with MMSE scores [beta = -0.62, 95% confidence interval (CI): -1.16 to -0.08] and CASI scores (beta = -1.97, 95% CI: -3.78 to -0.16), mainly in the CASI domains of long-term memory, mental manipulation, language ability, and spatial construction. However, there was no correlation between free PCS and total MMSE or total CASI scores after controlling for confounders. In conclusion, circulating free form IS, but not PCS is associated with lower cognitive function test scores in HD patients. Thus, a further study is needed to evaluate whether a decrease in free IS levels can slow down cognitive decline in HD patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
- 10 av 10
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Yi-Ting, Lin
- Wu, Ping-Hsun
- Liang, Shih-Shin
- Mubanga, Mwenya
- Yang, Yuan-Han
- Hsu, Ya-Ling
- visa fler...
- Kuo, Mei-Chuan
- Hwang, Shang-Jyh
- Kuo, Po-Lin
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Neurologi
- Artiklar i publikationen
- Scientific Repor ...
- Av lärosätet
- Uppsala universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
