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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007526naa a2200661 4500
001oai:DiVA.org:kth-211610
003SwePub
008170811s2017 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:139909947
009oai:DiVA.org:liu-144204
009oai:DiVA.org:uu-331243
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2116102 URI
0247 a https://doi.org/10.1172/jci.insight.936882 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1399099472 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1442042 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3312432 URI
040 a (SwePub)kthd (SwePub)kid (SwePub)liud (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ge, Changrong Pu Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sect Med Inflammat Res, Dept Med Biochem & Biophys, Stockholm, Sweden.4 aut
2451 0a Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage
264 1b AMER SOC CLINICAL INVESTIGATION INC,c 2017
338 a print2 rdacarrier
500 a QC 20170811
520 a Today, it is known that autoimmune diseases start a long time before clinical symptoms appear. Anti-citrullinated protein antibodies (ACPAs) appear many years before the clinical onset of rheumatoid arthritis (RA). However, it is still unclear if and how ACPAs are arthritogenic. To better understand the molecular basis of pathogenicity of ACPAs, we investigated autoantibodies reactive against the C1 epitope of collagen type II (CII) and its citrullinated variants. We found that these antibodies are commonly occurring in RA. A mAb (ACC1) against citrullinated C1 was found to cross-react with several noncitrullinated epitopes on native CII, causing proteoglycan depletion of cartilage and severe arthritis in mice. Structural studies by X-ray crystallography showed that such recognition is governed by a shared structural motif "RG-TG" within all the epitopes, including electrostatic potential-controlled citrulline specificity. Overall, we have demonstrated a molecular mechanism that explains how ACPAs trigger arthritis.
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
7001 a Tong, Dongmei Ru Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Southern Medical University, Guangzhou, China.,Karolinska Inst, Sect Med Inflammat Res, Dept Med Biochem & Biophys, Stockholm, Sweden.;Southern Med Univ, Dept Pathophysiol, Key Lab Shock & Microcirculat Res Guangdong, Guangzhou, Guangdong, Peoples R China.4 aut
7001 a Liang, Bibo Tu Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm,Southern Medical University, Guangzhou, China,Karolinska Inst, Sect Med Inflammat Res, Dept Med Biochem & Biophys, Stockholm, Sweden.;Southern Med Univ, Dept Pathophysiol, Key Lab Shock & Microcirculat Res Guangdong, Guangzhou, Guangdong, Peoples R China.4 aut
7001 a Lonnblom, Erik Su Karolinska Institutet,Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm,Karolinska Inst, Sect Med Inflammat Res, Dept Med Biochem & Biophys, Stockholm, Sweden.4 aut
7001 a Schneider, Nadine Ku University Hospital Frankfurt Goethe University, Frankfurt, Germany,Goethe Univ, Fraunhofer Inst Mol Biol & Appl Ecol IME, Project Grp Translat Med & Pharmacol, Frankfurt, Germany.;Goethe Univ, Div Rheumatol, Univ Hosp Frankfurt, Frankfurt, Germany.4 aut
7001 a Hagert, Cecilia Uu University of Turku, Finland,Univ Turku, Medicity Res Lab, Turku, Finland.;Natl Doctoral Programme Informat & Struct Biol, Turku, Finland.4 aut
7001 a Viljanen, Johan V.u Uppsala universitet,Organisk kemi4 aut0 (Swepub:uu)johvi609
7001 a Ayoglu, Burcuu KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Institute of Technology, Stockholm, Sweden,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, Affin Prote, Stockholm, Sweden.4 aut0 (Swepub:kth)u1kfjubd
7001 a Stawikowska, Roma Tu Florida Atlantic University, Jupiter, Florida, USA,Florida Atlantic Univ, Dept Chem & Biochem, Jupiter, FL USA.4 aut
7001 a Nilsson, Peter C.u KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab,KTH Royal Institute of Technology, Stockholm, Sweden,KTH Royal Inst Technol, Sch Biotechnol, Sci Life Lab, Affin Prote, Stockholm, Sweden.4 aut0 (Swepub:kth)u1ws88sk
7001 a Fields, Gregg Bu Florida Atlantic University, Jupiter, Florida, USA,Florida Atlantic Univ, Dept Chem & Biochem, Jupiter, FL USA.4 aut
7001 a Skogh, Thomasu Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland,Linkoping Univ, Dept Rheumatol, Dept Clin & Expt Med, Linkoping, Sweden.4 aut0 (Swepub:liu)thosk00
7001 a Kastbom, Alfu Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland,Linkoping Univ, Dept Rheumatol, Dept Clin & Expt Med, Linkoping, Sweden.4 aut0 (Swepub:liu)alfka05
7001 a Kihlberg, Janu Uppsala universitet,Organisk kemi4 aut0 (Swepub:uu)janki643
7001 a Burkhardt, Harald Tu University Hospital Frankfurt Goethe University, Frankfurt, Germany,Goethe Univ, Fraunhofer Inst Mol Biol & Appl Ecol IME, Project Grp Translat Med & Pharmacol, Frankfurt, Germany.;Goethe Univ, Div Rheumatol, Univ Hosp Frankfurt, Frankfurt, Germany.4 aut
7001 a Dobritzsch, Doreen,d 1972-u Uppsala universitet,Biokemi,Structural Biochemistry4 aut0 (Swepub:uu)dordo526
7001 a Holmdahl, Rikard Ku Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden; University of Turku, Turku, Finland, Southern Medical University, Guangzhou, China,Karolinska Inst, Sect Med Inflammat Res, Dept Med Biochem & Biophys, Stockholm, Sweden.;Univ Turku, Medicity Res Lab, Turku, Finland.;Natl Doctoral Programme Informat & Struct Biol, Turku, Finland.;Southern Med Univ, Ctr Med Immunopharmacol Res, Guangzhou, Guangdong, Peoples R China.4 aut
7001 a Ge, CRu Karolinska Institutet4 aut
7001 a Tong, DMu Karolinska Institutet4 aut
7001 a Liang, BB4 aut
7102 a Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Swedenb Karolinska Inst, Sect Med Inflammat Res, Dept Med Biochem & Biophys, Stockholm, Sweden.4 org
7730 t JCI INSIGHTd : AMER SOC CLINICAL INVESTIGATION INCg 2:13q 2:13x 2379-3708
8564 u http://insight.jci.org/articles/view/93688/files/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-211610
8564 8u https://doi.org/10.1172/jci.insight.93688
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:139909947
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-144204
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-331243

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