WFRF:(Hsueh A J)
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Cloning and characterization of a cDNA for rat tissue-type plasminogen activator.
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- Ny, Tor (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
- Leonardsson, G (author)
- Hsueh, A J (author)
- (creator_code:org_t)
- 1988
- 1988
- English.
- In: DNA (Mary Ann Liebert, Inc.). - 0198-0238. ; 7:10, s. 671-7
- Journal article (peer-reviewed)
Abstract
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- Two partly overlapping lambda gt11 cDNA clones coding for the 22S rat tissue-type plasminogen activator (t-PA) mRNA were isolated. The cDNA sequences cover 2445 nucleotides of the mRNA, including a 5' untranslated region of 31 nucleotides, an open reading frame of 1677 nucleotides, a 3' untranslated region of 737 nucleotides, and a poly(A) tail. The open reading frame codes for a 17-amino-acid signal peptide, a propeptide with 12 amino acids, and the mature protein with 530 amino acids. Rat t-PA has 81% and 92% amino acid sequence identity with the human and mouse counterparts and an equal distribution of conserved amino acids, suggesting that the proteins can fold into identical three-dimensional structures. The rat t-PA sequence contains two putative N-glycosylation sites at Asn-120 and Asn-452, while human t-PA has an additional glycosylation site at Asn-187. The site at Asn-187 is glycosylated in the human protein, revealing a different glycosylation pattern between the human and rat proteins.
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