WFRF:(Jonaitis Erin M)
Sökning: WFRF:(Jonaitis Erin M) > Age-accelerated cog...
- 10 av 12
- Föregående post
- Nästa post
- Till träfflistan
Age-accelerated cognitive decline in asymptomatic adults with CSF β-amyloid.
- Clark, Lindsay R (författare)
- Berman, Sara E (författare)
- Norton, Derek (författare)
- visa fler...
- Koscik, Rebecca L (författare)
- Jonaitis, Erin (författare)
- Bendlin, Barbara B (författare)
- Asthana, Sanjay (författare)
- Johnson, Sterling C (författare)
- Carlsson, Cynthia M (författare)
- visa färre...
- (creator_code:org_t)
- 2018
- 2018
- Engelska.
- Ingår i: Neurology. - 1526-632X. ; 90:15
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Compare cognitive and hippocampal volume trajectories in asymptomatic middle-aged and older adults with positive CSF markers of β-amyloid (Aβ) or tau to adults without an Alzheimer disease (AD)-associated biomarker profile.Three hundred ninety-two adults enrolled in a longitudinal cohort study (Wisconsin Registry for Alzheimer's Prevention or Wisconsin Alzheimer's Disease Research Center) completed a lumbar puncture and at least 2 biennial or annual neuropsychological evaluations. Cutoffs for Aβ42, total tau, and phosphorylated tau were developed via receiver operating characteristic curve analyses on a sample of 78 participants (38 dementia, 40 controls). These cutoffs were applied to a separate sample of 314 cognitively healthy adults (mean age at CSF collection = 61.5 years), and mixed-effects regression analyses tested linear and quadratic interactions of biomarker group × age at each visit on cognitive and hippocampal volume outcomes.Two hundred fifteen participants (69%) were biomarker negative (preclinical AD stage 0), 46 (15%) were Aβ+ only (preclinical AD stage 1), 25 (8%) were Aβ+ and tau+ (preclinical AD stage 2), and 28 (9%) were tau+ only. Both stage 1 and stage 2 groups exhibited greater rates of linear decline on story memory and processing speed measures, and nonlinear decline on list-learning and set-shifting measures compared to stage 0. The tau+ only group did not significantly differ from stage 0 in rates of cognitive decline.In an asymptomatic at-risk cohort, elevated CSF Aβ (with or without elevated tau) was associated with greater rates of cognitive decline, with the specific pattern of decline varying across cognitive measures.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
- 10 av 12
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Clark, Lindsay R
- Berman, Sara E
- Norton, Derek
- Koscik, Rebecca ...
- Jonaitis, Erin
- Blennow, Kaj, 19 ...
- visa fler...
- Bendlin, Barbara ...
- Asthana, Sanjay
- Johnson, Sterlin ...
- Zetterberg, Henr ...
- Carlsson, Cynthi ...
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Medicinska och f ...
- och Neurovetenskaper
- Artiklar i publikationen
- Neurology
- Av lärosätet
- Göteborgs universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
