Sökning: WFRF:(Joseph Amer) > Risk Factors for Gr...
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000 | 12124naa a2201165 4500 | |
001 | oai:DiVA.org:uu-419189 | |
003 | SwePub | |
008 | 200914s2020 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:144217400 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4191892 URI |
024 | 7 | a https://doi.org/10.1016/j.bbmt.2020.05.0012 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1442174002 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Im, Annieu Univ Pittsburgh, UPMC, Hillman Canc Ctr, Pittsburgh, PA USA.4 aut |
245 | 1 0 | a Risk Factors for Graft-versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide |
264 | 1 | b Elsevier BV,c 2020 |
338 | a print2 rdacarrier | |
520 | a Post-transplant cyclophosphamide (PTCy) has significantly increased the successful use of haploidentical donors with a relatively low incidence of graft-versus-host disease (GVHD). Given its increasing use, we sought to determine risk factors for GVHD after haploidentical hematopoietic cell transplantation (haplo-HCT) using PTCy. Data from the Center for International Blood and Marrow Transplant Research on adult patients with acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndrome, or chronic myeloid leukemia who underwent PTCy-based haplo-HCT (2013 to 2016) were analyzed and categorized into 4 groups based on myeloablative (MA) or reduced-intensity conditioning (RIC) and bone marrow (BM) or peripheral blood (PB) graft source. In total, 646 patients were identified (MA-BM = 79, MA-PB = 183, RIC-BM = 192, RIC-PB = 192). The incidence of grade 2 to 4 acute GVHD at 6 months was highest in MA-PB (44%), followed by RIC-PB (36%), MA-BM (36%), and RIC-BM (30%) (P = .002). The incidence of chronic GVHD at 1 year was 40%, 34%, 24%, and 20%, respectively (P < .001). In multivariable analysis, there was no impact of stem cell source or conditioning regimen on grade 2 to 4 acute GVHD; however, older donor age (30 to 49 versus <29 years) was significantly associated with higher rates of grade 2 to 4 acute GVHD (hazard ratio [HR], 1.53; 95% confidence interval [CI], 1.11 to 2.12; P = .01). In contrast, PB compared to BM as a stem cell source was a significant risk factor for the development of chronic GVHD (HR, 1.70; 95% CI, 1.11 to 2.62; P = .01) in the RIC setting. There were no differences in relapse or overall survival between groups. Donor age and graft source are risk factors for acute and chronic GVHD, respectively, after PTCy-based haplo-HCT. Our results indicate that in RIC haplo-HCT, the risk of chronic GVHD is higher with PB stem cells, without any difference in relapse or overall survival. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
700 | 1 | a Rashidi, Arminu Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA.4 aut |
700 | 1 | a Wang, Taou Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA.4 aut |
700 | 1 | a Hemmer, Michaelu Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.4 aut |
700 | 1 | a MacMillan, Margaret L.u Univ Minnesota, Dept Pediat, Blood & Marrow Transplant Program, Minneapolis, MN 55455 USA.4 aut |
700 | 1 | a Pidala, Josephu H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA.4 aut |
700 | 1 | a Jagasia, Madanu Vanderbilt Univ, Med Ctr, Nashville, TN USA.4 aut |
700 | 1 | a Pavletic, Stevenu NCI, Immune Deficiency Cellular Therapy Program, Ctr Canc Res, Bethesda, MD 20892 USA.4 aut |
700 | 1 | a Majhail, Navneet S.u Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, 9500 Euclid Ave,CA 60, Cleveland, OH 44195 USA.4 aut |
700 | 1 | a Weisdorf, Danielu Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA.4 aut |
700 | 1 | a Abdel-Azim, Hishamu Univ Southern Calif, Div Hematol Oncol & Blood & Marrow Transplantat, Childrens Hosp Los Angeles, Keck Sch Med, Los Angeles, CA 90007 USA.4 aut |
700 | 1 | a Agrawal, Vaibhavu Indiana Univ Sch Med, Div Hematol Oncol, Indianapolis, IN 46202 USA.4 aut |
700 | 1 | a Al-Homsi, A. Sameru NYU, Langone Med Ctr, New York, NY USA.4 aut |
700 | 1 | a Aljurf, Mahmoudu King Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.4 aut |
700 | 1 | a Askar, Medhatu Baylor Univ, Med Ctr, Dept Pathol & Lab Med, Dallas, TX USA.4 aut |
700 | 1 | a Auletta, Jeffery J.u Nationwide Childrens Hosp, Blood & Marrow Transplant Program, Columbus, OH USA.;Nationwide Childrens Hosp, Host Def Program, Div Hematol, Columbus, OH USA.;Nationwide Childrens Hosp, Div Oncol, Host Def Program, Columbus, OH USA.;Nationwide Childrens Hosp, Div Bone Marrow Transplant, Host Def Program, Columbus, OH USA.;Nationwide Childrens Hosp, Div Infect Dis, Host Def Program, Columbus, OH USA.4 aut |
700 | 1 | a Bashey, Asadu Northside Hosp, Blood & Marrow Transplant Program, Atlanta, GA USA.4 aut |
700 | 1 | a Beitinjaneh, Ameru Univ Miami, Dept Hematol & Oncol, Miami, FL USA.4 aut |
700 | 1 | a Bhatt, Vijaya Raju Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA.4 aut |
700 | 1 | a Byrne, Michaelu Vanderbilt Univ, Med Ctr, Nashville, TN USA.4 aut |
700 | 1 | a Cahn, Jean-Yvesu CHU Grenoble Alpes, Dept Hematol, Grenoble, France.4 aut |
700 | 1 | a Cairo, Mitchellu New York Med Coll, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, Valhalla, NY 10595 USA.4 aut |
700 | 1 | a Castillo, Paulu UF Hlth Shands Childrens Hosp, Gainesville, FL USA.4 aut |
700 | 1 | a Cerny, Janu Univ Massachusetts, Med Ctr, Dept Med, Div Hematol Oncol, Worcester, MA USA.4 aut |
700 | 1 | a Chhabra, Saurabhu Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.4 aut |
700 | 1 | a Choe, Hannahu Ohio State Univ, Wexner Med Ctr, James Comprehens Canc Ctr, Columbus, OH 43210 USA.4 aut |
700 | 1 | a Ciurea, Stefanu Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.4 aut |
700 | 1 | a Daly, Andrewu Tom Baker Canc Clin, Calgary, AB, Canada.4 aut |
700 | 1 | a Diaz Perez, Miguel Angelu Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain.4 aut |
700 | 1 | a Farhadfar, Noshau Univ Florida, Coll Med, Div Hematol Oncol, Gainesville, FL USA.4 aut |
700 | 1 | a Gadalla, Shahinaz M.u NCI, Div Canc Epidemiol & Genet, NIH, Clin Genet Branch, Rockville, MD USA.4 aut |
700 | 1 | a Gale, Robertu Imperial Coll London, Hematol Res Ctr, Dept Med, Div Expt Med, London, England.4 aut |
700 | 1 | a Ganguly, Siddharthau Univ Kansas Hlth Syst, Div Hematol Malignancy & Cellular Therapeut, Kansas City, KS USA.4 aut |
700 | 1 | a Gergis, Usamau Thomas Jefferson Univ, Dept Med Oncol, Philadelphia, PA USA.4 aut |
700 | 1 | a Hanna, Rabiu Cleveland Clin Fdn, 9500 Euclid Ave, Cleveland, OH 44195 USA.4 aut |
700 | 1 | a Hematti, Peimanu Univ Wisconsin, Dept Med, Div Hematol Oncol Bone Marrow Transplantat, Madison, WI USA.4 aut |
700 | 1 | a Herzig, Rogeru Univ Kentucky, Chandler Med Ctr, Louisville, KY USA.4 aut |
700 | 1 | a Hildebrandt, Gerhard C.u Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.4 aut |
700 | 1 | a Lad, Deepesh P.u Postgrad Inst Med Educ & Res, Dept Internal Med, Chandigarh, India.4 aut |
700 | 1 | a Lee, Catherineu Univ Utah, Huntsman Canc Inst, Utah Blood & Marrow Transplant Program, Salt Lake City, UT USA.4 aut |
700 | 1 | a Lehmann, Leslieu Boston Childrens Hosp, Dana Farber Canc Inst, Boston, MA USA.4 aut |
700 | 1 | a Lekakis, Lazarosu Univ Miami, Dept Hematol & Oncol, Miami, FL USA.4 aut |
700 | 1 | a Kamble, Rammurti T.u Baylor Coll Med, Ctr Cell & Gene Therapy, Div Hematol & Oncol, Houston, TX 77030 USA.4 aut |
700 | 1 | a Kharfan-Dabaja, Mohamed A.u Mayo Clin, Div Hematol Oncol, Blood & Marrow Transplantat Program, Jacksonville, FL USA.4 aut |
700 | 1 | a Khandelwal, Poojau Cincinnati Childrens Hosp Med Ctr, Div Bone Marrow Transplant & Immune Deficiency, Cincinnati, OH 45229 USA.;Univ Cincinnati, Dept Pediat, Cincinnati, OH USA.4 aut |
700 | 1 | a Martino, Rodrigou Hosp Santa Creu & Sant Pau, Div Clin Hematol, Barcelona, Spain.4 aut |
700 | 1 | a Murthy, Hemant S.u Mayo Clin, Div Hematol Oncol, Blood & Marrow Transplantat Program, Jacksonville, FL USA.4 aut |
700 | 1 | a Nishihori, Taigau H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.4 aut |
700 | 1 | a O'Brien, Tracey A.u Sydney Childrens Hosp, Kids Canc Ctr, Blood & Marrow Transplant Program, Sydney, NSW, Australia.4 aut |
700 | 1 | a Olsson, Richardu Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden.4 aut0 (Swepub:uu)riols677 |
700 | 1 | a Patel, Sagar S.u Univ Utah, Blood & Marrow Transplant Program, Salt Lake City, UT USA.4 aut |
700 | 1 | a Perales, Miguel-Angelu Mem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplant Serv, 1275 York Ave, New York, NY 10021 USA.4 aut |
700 | 1 | a Prestidge, Timu Starship Childrens Hosp, Blood & Canc Ctr, Auckland, New Zealand.4 aut |
700 | 1 | a Qayed, Munau Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA.4 aut |
700 | 1 | a Romee, Rizwanu Dana Farber Canc Inst, Boston, MA 02115 USA.4 aut |
700 | 1 | a Schoemans, Heleneu Univ Hosp Leuven, Dept Hematol, Leuven, Belgium.;Katholieke Univ Leuven, Leuven, Belgium.4 aut |
700 | 1 | a Seo, Sachikou Dokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan.4 aut |
700 | 1 | a Sharma, Akshayu St Jude Childrens Res Hosp, Dept Bone Marrow Transplantat & Cellular Therapy, 332 N Lauderdale St, Memphis, TN 38105 USA.4 aut |
700 | 1 | a Solh, Melhemu Northside Hosp, Blood & Marrow Transplant Grp Georgia, Atlanta, GA USA.4 aut |
700 | 1 | a Strair, Rogeru Rutgers State Univ, Rutgers Canc Inst New Jersey, Brunswick, NJ USA.4 aut |
700 | 1 | a Teshima, Takanoriu Hokkaido Univ Hosp, Sapporo, Hokkaido, Japan.4 aut |
700 | 1 | a Urbano-Ispizua, Alvarou Univ Barcelona, Hosp Clin, IDIBAPS, Dept Hematol, Barcelona, Spain.;Inst Res Josep Carreras, Barcelona, Spain.4 aut |
700 | 1 | a Van der Poel, Marjoleinu Maastricht Univ, Med Ctr, Maastricht, Netherlands.4 aut |
700 | 1 | a Vij, Raviu Washington Univ, Sch Med, Div Hematol & Oncol, St Louis, MO USA.4 aut |
700 | 1 | a Wagner, John L.u Thomas Jefferson Univ, Dept Med Oncol, Philadelphia, PA USA.4 aut |
700 | 1 | a William, Basemu Ohio State Univ, Div Hematol, Columbus, OH 43210 USA.4 aut |
700 | 1 | a Wirk, Baldeepu Penn State Canc Inst, Bone Marrow Transplant Program, Hershey, PA USA.4 aut |
700 | 1 | a Yared, Jean A.u Univ Maryland, Dept Med, Greenebaum Comprehens Canc Ctr, Blood & Marrow Transplantat Program,Div Hematol O, Baltimore, MD 21201 USA.4 aut |
700 | 1 | a Spellman, Steve R.u Med Coll Wisconsin, Dept Med, CIBMTR, Milwaukee, WI 53226 USA.4 aut |
700 | 1 | a Arora, Muktau Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA.4 aut |
700 | 1 | a Hamilton, Betty K.u Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, 9500 Euclid Ave,CA 60, Cleveland, OH 44195 USA.4 aut |
710 | 2 | a Univ Pittsburgh, UPMC, Hillman Canc Ctr, Pittsburgh, PA USA.b Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA.4 org |
773 | 0 | t Biology of blood and marrow transplantationd : Elsevier BVg 26:8, s. 1459-1468q 26:8<1459-1468x 1083-8791x 1523-6536 |
856 | 4 | u http://www.astctjournal.org/article/S108387912030286X/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419189 |
856 | 4 8 | u https://doi.org/10.1016/j.bbmt.2020.05.001 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:144217400 |
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