WFRF:(Kashuba Elena)
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Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes
- Yenamandra, Surya Pavan (author)
-
- Hellman, Ulf (author)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
- Kempkes, Bettina (author)
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- Petermann, Sabine (author)
- Sculley, Tom (author)
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- (creator_code:org_t)
- 2010-07-01
- 2010
- English.
- In: Cellular and Molecular Life Sciences (CMLS). - : Springer Science and Business Media LLC. - 1420-682X .- 1420-9071. ; 67:24, s. 4249-4256
- Journal article (peer-reviewed)
Abstract
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- Epstein-Barr virus (EBV) is a human gamma herpes virus that infects B cells and induces their transformation into immortalized lymphoblasts that can grow as cell lines (LCLs) in vitro. EBNA-3 is a member of the EBNA-3-protein family that can regulate transcription of cellular and viral genes. The identification of EBNA-3 cellular partners and a study of its influence on cellular pathways are important for understanding the transforming action of the virus. In this work, we have identified the vitamin D receptor (VDR) protein as a binding partner of EBNA-3. We found that EBNA3 blocks the activation of VDR-dependent genes and protects LCLs against vitamin-D3-induced growth arrest and/or apoptosis. The presented data shed some light on the anti-apoptotic EBV program and the role of the EBNA-3-VDR interaction in the viral strategy.
Keyword
- EBV
- VDR
- Transcription regulation
- EBNA
- Vitamin D3
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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