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- Rudberg, S (författare)
Indications that branched chain amino acids, in addition to glucagon, affect the glomerular filtration rate after a high protein diet in insulin-dependent diabetes
- Artikel/kapitelEngelska1991
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- Edinburgh, Scotland :Teviot-Kimpton Publications,1991
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- LIBRIS-ID:oai:DiVA.org:umu-88545
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-88545URI
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- Språk:engelska
- Sammanfattning på:engelska
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- Hormonal changes and whole blood free amino acid levels and their relation to renal function were measured in 12 insulin-dependent diabetic patients after two 10-day periods with a diet consisting of 10% and 20% respectively of the energy as protein. The patients were 15-21 years old and mean duration of diabetes was 12 (5-20) years. Glomerular filtration rate, renal plasma flow, and albumin excretion rate were measured together with plasma concentrations of glucagon, growth hormone, insulin-like growth factor 1 (IGF-1), somatostatin, serum insulin and free amino acids in blood. Glomerular filtration rate was 123 +/- 3 ml/min/1.73 m2 on high protein diet and 113 +/- 3 ml/min/1.73 m2 on low protein diet (p = 0.02). Renal plasma flow was unchanged. Glucagon, IGF-1, branch chained amino acids (BCAA), tyrosine, phenylalanine, lysine, and methionine were increased after the high protein diet. Growth hormone, somatostatin, insulin, and other amino acids remained unchanged. The increase in glomerular filtration rate was significantly correlated to the increase in glucagon, isoleucine, and valine (glucagon r = 0.71, p = 0.01, isoleucine r = 0.59, p = 0.04, valine r = 0.62, p = 0.03). In a multiple regression model the increase in glomerular filtration correlated most strongly to the increase in isoleucine, followed by valine and glucagon. Together these variables explained 88% of the total variance of the change in glomerular filtration rate (r2 = 0.88, p = 0.001). Albumin excretion rate was correlated to IGF-1 (r = 0.86, p < 0.001) on the high protein diet. The regulation of GFR seems to depend on a combined effect of BCCA and glucagon, whereas microalbuminuria seems to be related to IGF-1.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
- TYPE-1 (INSULIN-DEPENDENT) DIABETES
- HIGH PROTEIN DIET
- GLOMERULAR FILTRATION RATE
- GLUCAGON
- BRANCH CHAINED AMINO ACIDS
- INSULIN-LIKE GROWTH FACTOR
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Dahlquist, GiselaSachs' Children's Hospitals, Department of Pediatrics(Swepub:umu)gida0001 (författare)
- Aperia, A (författare)
- Lindblad, B S (författare)
- Efendic, S (författare)
- Skottner, A (författare)
- Persson, B (författare)
- Sachs' Children's Hospitals, Department of Pediatrics (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Diabetes researchEdinburgh, Scotland : Teviot-Kimpton Publications16:3, s. 101-1090265-5985
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