Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals

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Fältnamn	Indikatorer	Metadata
000		21122naa a2201633 4500
001		oai:DiVA.org:uu-303129
003		SwePub
008		160915s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3031292 URI
024	7	a https://doi.org/10.1016/j.ajhg.2016.05.0052 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Eicher, John D.u NHLBI, Populat Sci Branch, Framingham Heart Study, Framingham, MA 01702 USA.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.4 aut
245	1 0	a Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals
264	1	b Elsevier BV,c 2016
338		a print2 rdacarrier
520		a Platelet production, maintenance, and clearance are tightly controlled processes indicative of platelets' important roles in hemostasis and thrombosis. Platelets are common targets for primary and secondary prevention of several conditions. They are monitored clinically by complete blood counts, specifically with measurements of platelet count (PLT) and mean platelet volume (MPV). Identifying genetic effects on PLT and MPV can provide mechanistic insights into platelet biology and their role in disease. Therefore, we formed the Blood Cell Consortium (BCX) to perform a large-scale meta-analysis of Exomechip association results for PLT and MPV in 157,293 and 57,617 individuals, respectively. Using the low-frequency/rare coding variant-enriched Exomechip genotyping array, we sought to identify genetic variants associated with PLT and MPV. In addition to confirming 47 known PLT and 20 known MPV associations, we identified 32 PLT and 18 MPV associations not previously observed in the literature across the allele frequency spectrum, including rare large effect (FCER1A), low-frequency (IQGAP2, MAP1A, LY75), and common(ZMIZ2, SMG6, PEAR1, ARFGAP3/PACSIN2) variants. Several variants associated with PLT/MPV(PEAR1, MRVI1, PTGES3) were also associated with platelet reactivity. In concurrent BCX analyses, there was overlap of platelet-associated variants with red (MAP1A, TMPRSS6, ZMIZ2) and white (PEAR1, ZMIZ2, LY75) blood cell traits, suggesting common regulatory pathways with shared genetic architecture among these hematopoietic lineages. Our large-scale Exomechip analyses identified previously undocumented associations with platelet traits and further indicate that several complex quantitative hematological, lipid, and cardiovascular traits share genetic factors.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Chami, Nathalieu Univ Montreal, Dept Med, Montreal, PQ H3T 1J4, Canada.;Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.4 aut
700	1	a Kacprowski, Timu Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Dept Funct Genom, D-17475 Greifswald, Germany.;Ernst Mortiz Arndt Univ Greifswald, D-17475 Greifswald, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.4 aut
700	1	a Nomura, Akihirou Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Harvard Med Sch, Dept Med, Boston, MA 02115 USA.;Kanazawa Univ, Div Cardiovasc Med, Grad Sch Med Sci, Kanazawa, Ishikawa 9200942, Japan.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.4 aut
700	1	a Chen, Ming-Hueiu NHLBI, Populat Sci Branch, Framingham Heart Study, Framingham, MA 01702 USA.4 aut
700	1	a Yanek, Lisa R.u Johns Hopkins Univ, Div Gen Internal Med, Dept Med, Sch Med, Baltimore, MD 21205 USA.4 aut
700	1	a Tajuddin, Salman M.u NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD 21224 USA.4 aut
700	1	a Schick, Ursula M.u Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA.4 aut
700	1	a Slater, Andrew J.u GlaxoSmithKline, Genet, Target Sci, Res Triangle Pk, NC 27709 USA.;OmicSoft Corp, Cary, NC 27513 USA.4 aut
700	1	a Pankratz, Nathanu Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55454 USA.4 aut
700	1	a Polfus, Lindau Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Human Genet, Houston, TX 77030 USA.4 aut
700	1	a Schurmann, Claudiau Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA.4 aut
700	1	a Giri, Ayushu Vanderbilt Univ, Inst Med & Publ Hlth, Div Epidemiol, Nashville, TN 37235 USA.4 aut
700	1	a Brody, Jennifer A.u Univ Washington, Dept Med, Seattle, WA 98101 USA.4 aut
700	1	a Lange, Leslie A.u Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USA.4 aut
700	1	a Manichaikul, Aniu Univ Virginia, Ctr Publ Hlth Gen, Charlottesville, VA 22908 USA.4 aut
700	1	a Hill, W. Davidu Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland.;Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland.4 aut
700	1	a Pazoki, Rahau Erasmus MC, Dept Epidemiol, NL-3000 Rotterdam, Netherlands.4 aut
700	1	a Elliot, Paulu Univ London Imperial Coll Sci Technol & Med, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.4 aut
700	1	a Evangelou, Evangelosu Univ London Imperial Coll Sci Technol & Med, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.;Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina 45110, Greece.4 aut
700	1	a Tzoulaki, Ioannau Univ London Imperial Coll Sci Technol & Med, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.;Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina 45110, Greece.4 aut
700	1	a Gao, Heu Univ London Imperial Coll Sci Technol & Med, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.4 aut
700	1	a Vergnaud, Anne-Claireu Univ London Imperial Coll Sci Technol & Med, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.4 aut
700	1	a Mathias, Rasika A.u Johns Hopkins Univ, Div Gen Internal Med, Dept Med, Sch Med, Baltimore, MD 21205 USA.;Johns Hopkins Univ, Sch Med, Dept Med, Div Allergy, Baltimore, MD 21205 USA.;Johns Hopkins Univ, Sch Med, Dept Med, Div Immunol, Baltimore, MD 21205 USA.4 aut
700	1	a Becker, Diane M.u Johns Hopkins Univ, Div Gen Internal Med, Dept Med, Sch Med, Baltimore, MD 21205 USA.4 aut
700	1	a Becker, Lewis C.u Johns Hopkins Univ, Div Gen Internal Med, Dept Med, Sch Med, Baltimore, MD 21205 USA.;Johns Hopkins Univ, Div Cardiol, Dept Med, Sch Med, Baltimore, MD 21205 USA.4 aut
700	1	a Burt, Amberu Univ Washington, Div Med Genet, Dept Med, Seattle, WA 98195 USA.4 aut
700	1	a Crosslin, David R.u Univ Washington, Dept Biomed Informat & Med Educ, Seattle, WA 98105 USA.4 aut
700	1	a Lyytikainen, Leo-Pekkau Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland.;Univ Tampere, Dept Clin Chem, Sch Med, Tampere 33514, Finland.4 aut
700	1	a Nikus, Kjellu Tampere Univ Hosp, Dept Cardiol, Ctr Heart, Tampere 33521, Finland.;Univ Tampere, Sch Med, Tampere 33514, Finland.4 aut
700	1	a Hernesniemi, Jussiu Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland.;Univ Tampere, Dept Clin Chem, Sch Med, Tampere 33514, Finland.;Tampere Univ Hosp, Dept Cardiol, Ctr Heart, Tampere 33521, Finland.4 aut
700	1	a Kahonen, Mikau Tampere Univ Hosp, Dept Clin Physiol, Tampere 33521, Finland.;Univ Tampere, Dept Clin Physiol, Tampere 33514, Finland.4 aut
700	1	a Raitoharju, Emmau Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland.;Univ Tampere, Dept Clin Chem, Sch Med, Tampere 33514, Finland.4 aut
700	1	a Mononen, Ninau Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland.;Univ Tampere, Dept Clin Chem, Sch Med, Tampere 33514, Finland.4 aut
700	1	a Raitakari, Olli T.u Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku 20521, Finland.;Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, FIN-20520 Turku, Finland.4 aut
700	1	a Lehtimaki, Terhou Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland.;Univ Tampere, Dept Clin Chem, Sch Med, Tampere 33514, Finland.4 aut
700	1	a Cushman, Maryu Univ Vermont, Coll Med, Dept Med, Burlington, VT 05405 USA.;Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA.4 aut
700	1	a Zakai, Neil A.u Univ Vermont, Coll Med, Dept Med, Burlington, VT 05405 USA.;Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA.4 aut
700	1	a Nickerson, Deborah A.u Univ Washington, Dept Genome Sci, Seattle, WA 98105 USA.4 aut
700	1	a Raffield, Laura M.u Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USA.4 aut
700	1	a Quarells, Rakaleu Morehouse Sch Med, Social Epidemiol Res Ctr, Cardiovasc Res Inst, Atlanta, GA 30310 USA.4 aut
700	1	a Willer, Cristen J.u Univ Michigan, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI 48108 USA.;Univ Michigan, Dept Computat Med & Bioinformat, Dept Human Genet, Ann Arbor, MI 48108 USA.;Univ Michigan, Dept Biostat, Ann Arbor, MI 48108 USA.4 aut
700	1	a Peloso, Gina M.u Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA.;Boston Univ, Dept Biostat, Sch Publ Hlth, Boston, MA 02118 USA.4 aut
700	1	a Abecasis, Goncalo R.u Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48108 USA.4 aut
700	1	a Liu, Dajiang J.u Penn State Univ Hosp, Dept Publ Hlth Sci, Coll Med, Hershey, PA 17033 USA.4 aut
700	1	a Deloukas, Panosu Queen Mary Univ London, William Harvey Res Inst, London E1 4NS, England.;King Abdulaziz Univ, Princess Al Jawhara Al Brahim Ctr Excellence Res, Jeddah 21589, Saudi Arabia.4 aut
700	1	a Samani, Nilesh J.u Univ Leicester, Dept Cardiovasc Sci, Leicester LE1 7RH, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester LE3 9QP, Leics, England.4 aut
700	1	a Schunkert, Heribertu DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, D-80333 Munich, Germany.;Tech Univ Munich, Deutsch Herzzentrum Munchen, D-80333 Munich, Germany.4 aut
700	1	a Erdmann, Jeanetteu Univ Lubeck, Inst Integrat & Expt Genom, D-23562 Lubeck, Germany.;DZHK German Res Ctr Cardiovasc Res, Partner Site Hamburg Lubeck Kiel, D-23562 Lubeck, Germany.4 aut
700	1	a Fornage, Myriamu Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Houston, TX 77030 USA.4 aut
700	1	a Richard, Melissau Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Houston, TX 77030 USA.4 aut
700	1	a Tardif, Jean-Claudeu Univ Montreal, Dept Med, Montreal, PQ H3T 1J4, Canada.;Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.4 aut
700	1	a Rioux, John D.u Univ Montreal, Dept Med, Montreal, PQ H3T 1J4, Canada.;Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.4 aut
700	1	a Dube, Marie-Pierreu Univ Montreal, Dept Med, Montreal, PQ H3T 1J4, Canada.;Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.4 aut
700	1	a de Denus, Simonu Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.;Univ Montreal, Fac Pharm, Montreal H3T 1J4, PQ, Canada.4 aut
700	1	a Lu, Yingchangu Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.4 aut
700	1	a Bottinger, Erwin P.u Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.4 aut
700	1	a Loos, Ruth J. F.u Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.4 aut
700	1	a Smith, Albert Vernonu Icelandic Heart Assoc, IS-201 Kopavogur, Iceland.;Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland.4 aut
700	1	a Harris, Tamara B.u NIA, Lab Epidemiol Demog & Biometry, Intramural Res Program, NIH, Baltimore, MD 21224 USA.4 aut
700	1	a Launer, Lenore J.u NIA, Lab Epidemiol Demog & Biometry, Intramural Res Program, NIH, Baltimore, MD 21224 USA.4 aut
700	1	a Gudnason, Vilmunduru Icelandic Heart Assoc, IS-201 Kopavogur, Iceland.;Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland.4 aut
700	1	a Edwards, Digna R. Velezu Vanderbilt Univ, Vanderbilt Epidemiol Ctr, Dept Obstet & Gynecol, Inst Med & Publ Hlth,Vanderbilt Genet Inst, Nashville, TN 37203 USA.4 aut
700	1	a Torstenson, Eric S.u Vanderbilt Univ, Inst Med & Publ Hlth, Div Epidemiol, Nashville, TN 37235 USA.4 aut
700	1	a Liu, Yongmeiu Wake Forest Sch Med, Div Publ Hlth Sci, Ctr Human Genet, Winston Salem, NC 27157 USA.4 aut
700	1	a Tracy, Russell P.u Univ Vermont, Coll Med, Dept Pathol & Lab Med, Colchester, VT 05446 USA.;Univ Vermont, Coll Med, Dept Biochem, Colchester, VT 05446 USA.4 aut
700	1	a Rotter, Jerome I.u Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA 90502 USA.;Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA 90502 USA.4 aut
700	1	a Rich, Stephen S.u Univ Virginia, Ctr Publ Hlth Gen, Charlottesville, VA 22908 USA.4 aut
700	1	a Highland, Heather M.u Univ Texas Hlth Sci Ctr Houston, Univ Texas Grad Sch Biomed Sci Houston, Univ Texas Sch Publ Hlth, Houston, TX 77030 USA.;Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27514 USA.4 aut
700	1	a Boerwinkle, Ericu Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Human Genet, Houston, TX 77030 USA.;Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA.4 aut
700	1	a Li, Jinu Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Palo Alto, CA 94305 USA.4 aut
700	1	a Lange, Ethanu Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USA.;Univ N Carolina, Dept Biostat, Chapel Hill, NC 27514 USA.4 aut
700	1	a Wilson, James G.u Univ Mississippi, Dept Physiol & Biophys, Med Ctr, Jackson, MS 39216 USA.4 aut
700	1	a Mihailov, Evelinu Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia.4 aut
700	1	a Magi, Reediku Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia.4 aut
700	1	a Hirschhorn, Joelu Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA.;Boston Childrens Hosp, Dept Endocrinol, Boston, MA 02115 USA.4 aut
700	1	a Metspalu, Andresu Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia.4 aut
700	1	a Esko, Tonuu Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA.;Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia.4 aut
700	1	a Vacchi-Suzzi, Caterinau SUNY Stony Brook, Dept Family Populat & Prevent Med, Stony Brook, NY 11794 USA.4 aut
700	1	a Nalls, Mike A.u NIA, Neurogenet Lab, NIH, Bethesda, MD 21224 USA.4 aut
700	1	a Zonderman, Alan B.u NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD 21224 USA.4 aut
700	1	a Evans, Michele K.u NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD 21224 USA.4 aut
700	1	a Engstrom, Gunnaru Lund Univ, Dept Clin Sci Malmo, S-22100 Malmo, Sweden.;Skane Univ Hosp, S-22241 Malmo, Sweden.4 aut
700	1	a Orho-Melander, Marjuu Lund Univ, Dept Clin Sci Malmo, S-22100 Malmo, Sweden.;Skane Univ Hosp, S-22241 Malmo, Sweden.4 aut
700	1	a Melander, Olleu Lund Univ, Dept Clin Sci Malmo, S-22100 Malmo, Sweden.;Skane Univ Hosp, S-22241 Malmo, Sweden.4 aut
700	1	a O'Donoghue, Michelle L.u Brigham & Womens Hosp, TIMI Study Grp, Div Cardiovasc, Boston, MA 02115 USA.4 aut
700	1	a Waterworth, Dawn M.u GlaxoSmithKline, Target Sci, Genet, King Of Prussia, PA 19406 USA.4 aut
700	1	a Wallentin, Larsu Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)larswall
700	1	a White, Harvey D.u Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland 1142, New Zealand.;Univ Auckland, Auckland 1142, New Zealand.4 aut
700	1	a Floyd, James S.u Univ Washington, Dept Med, Seattle, WA 98101 USA.4 aut
700	1	a Bartz, Traci M.u Univ Washington, Dept Biostat, Seattle, WA 98195 USA.4 aut
700	1	a Rice, Kenneth M.u Univ Washington, Dept Biostat, Seattle, WA 98195 USA.4 aut
700	1	a Psaty, Bruce M.u Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98101 USA.;Univ Washington, Dept Hlth Serv, Seattle, WA 98101 USA.;Grp Hlth Res Inst, Grp Hlth Cooperat, Seattle, WA 98101 USA.4 aut
700	1	a Starr, J. M.u Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland.;Alzheimer Scotland Res Ctr, Edinburgh EH8 9JZ, Midlothian, Scotland.4 aut
700	1	a Liewald, David C. M.u Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland.;Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland.4 aut
700	1	a Hayward, Carolineu Univ Edinburgh, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland.4 aut
700	1	a Deary, Ian J.u Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland.;Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland.4 aut
700	1	a Greinacher, Andreasu Univ Med Greifswald, Inst Immunol & Transfus Med, D-17475 Greifswald, Germany.4 aut
700	1	a Volker, Uweu Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Dept Funct Genom, D-17475 Greifswald, Germany.;Ernst Mortiz Arndt Univ Greifswald, D-17475 Greifswald, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.4 aut
700	1	a Thiele, Thomasu Univ Med Greifswald, Inst Immunol & Transfus Med, D-17475 Greifswald, Germany.4 aut
700	1	a Volzke, Henryu DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Inst Community Med, D-13347 Greifswald, Germany.4 aut
700	1	a van Rooij, Frank J. A.u Erasmus MC, Dept Epidemiol, NL-3000 Rotterdam, Netherlands.4 aut
700	1	a Uitterlinden, Andre G.u Erasmus MC, Dept Epidemiol, NL-3000 Rotterdam, Netherlands.;Erasmus MC, Dept Internal Med, NL-3000 Rotterdam, Netherlands.;Netherlands Consortium Hlth Ageing, NL-3015 Rotterdam, Netherlands.4 aut
700	1	a Franco, Oscar H.u Erasmus MC, Dept Epidemiol, NL-3000 Rotterdam, Netherlands.4 aut
700	1	a Dehghan, Abbasu Erasmus MC, Dept Epidemiol, NL-3000 Rotterdam, Netherlands.4 aut
700	1	a Edwards, Todd L.u Vanderbilt Univ, Inst Med & Publ Hlth, Div Epidemiol, Nashville, TN 37235 USA.4 aut
700	1	a Ganesh, Santhi K.u Univ Michigan, Dept Internal & Human Genet, Ann Arbor, MI 48108 USA.4 aut
700	1	a Kathiresan, Sekaru Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Harvard Med Sch, Dept Med, Boston, MA 02115 USA.4 aut
700	1	a Faraday, Nauderu Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.4 aut
700	1	a Auer, Paul L.u Univ Wisconsin, Zilber Sch Publ Hlth, Milwaukee, WI 53205 USA.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.4 aut
700	1	a Reiner, Alex P.u Univ Washington, Dept Epidemiol, Seattle, WA 98105 USA.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.4 aut
700	1	a Lettre, Guillaumeu Univ Montreal, Dept Med, Montreal, PQ H3T 1J4, Canada.;Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.4 aut
700	1	a Johnson, Andrew D.u NHLBI, Populat Sci Branch, Framingham Heart Study, Framingham, MA 01702 USA.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.4 aut
710	2	a NHLBI, Populat Sci Branch, Framingham Heart Study, Framingham, MA 01702 USA.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.b Univ Montreal, Dept Med, Montreal, PQ H3T 1J4, Canada.;Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.4 org
773	0	t American Journal of Human Geneticsd : Elsevier BVg 99:1, s. 40-55q 99:1<40-55x 0002-9297x 1537-6605
856	4	u http://www.cell.com/article/S0002929716301392/pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-303129
856	4 8	u https://doi.org/10.1016/j.ajhg.2016.05.005

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Av författaren/redakt...: Eicher, John D.; Chami, Nathalie; Kacprowski, Tim; Nomura, Akihiro; Chen, Ming-Huei; Yanek, Lisa R.; visa fler...; Tajuddin, Salman ...; Schick, Ursula M ...; Slater, Andrew J ...; Pankratz, Nathan; Polfus, Linda; Schurmann, Claud ...; Giri, Ayush; Brody, Jennifer ...; Lange, Leslie A.; Manichaikul, Ani; Hill, W. David; Pazoki, Raha; Elliot, Paul; Evangelou, Evang ...; Tzoulaki, Ioanna; Gao, He; Vergnaud, Anne-C ...; Mathias, Rasika ...; Becker, Diane M.; Becker, Lewis C.; Burt, Amber; Crosslin, David ...; Lyytikainen, Leo ...; Nikus, Kjell; Hernesniemi, Jus ...; Kahonen, Mika; Raitoharju, Emma; Mononen, Nina; Raitakari, Olli ...; Lehtimaki, Terho; Cushman, Mary; Zakai, Neil A.; Nickerson, Debor ...; Raffield, Laura ...; Quarells, Rakale; Willer, Cristen ...; Peloso, Gina M.; Abecasis, Goncal ...; Liu, Dajiang J.; Deloukas, Panos; Samani, Nilesh J ...; Schunkert, Herib ...; Erdmann, Jeanett ...; Fornage, Myriam; Richard, Melissa; Tardif, Jean-Cla ...; Rioux, John D.; Dube, Marie-Pier ...; de Denus, Simon; Lu, Yingchang; Bottinger, Erwin ...; Loos, Ruth J. F.; Smith, Albert Ve ...; Harris, Tamara B ...; Launer, Lenore J ...; Gudnason, Vilmun ...; Edwards, Digna R ...; Torstenson, Eric ...; Liu, Yongmei; Tracy, Russell P ...; Rotter, Jerome I ...; Rich, Stephen S.; Highland, Heathe ...; Boerwinkle, Eric; Li, Jin; Lange, Ethan; Wilson, James G.; Mihailov, Evelin; Magi, Reedik; Hirschhorn, Joel; Metspalu, Andres; Esko, Tonu; Vacchi-Suzzi, Ca ...; Nalls, Mike A.; Zonderman, Alan ...; Evans, Michele K ...; Engstrom, Gunnar; Orho-Melander, M ...; Melander, Olle; O'Donoghue, Mich ...; Waterworth, Dawn ...; Wallentin, Lars; White, Harvey D.; Floyd, James S.; Bartz, Traci M.; Rice, Kenneth M.; Psaty, Bruce M.; Starr, J. M.; Liewald, David C ...; Hayward, Carolin ...; Deary, Ian J.; Greinacher, Andr ...; Volker, Uwe; Thiele, Thomas; Volzke, Henry; van Rooij, Frank ...; Uitterlinden, An ...; Franco, Oscar H.; Dehghan, Abbas; Edwards, Todd L.; Ganesh, Santhi K ...; Kathiresan, Seka ...; Faraday, Nauder; Auer, Paul L.; Reiner, Alex P.; Lettre, Guillaum ...; Johnson, Andrew ...; visa färre...

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