WFRF:(Lindqvist David)
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Discovery of 4 '-azido-2 '-deoxy-2 '-C-methyl cytidine and prodrugs thereof : A potent inhibitor of Hepatitis C virus replication
- Nilsson, Magnus (author)
- Kalayanov, Genadiy (author)
- Winqvist, Anna (author)
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- Pinho, Pedro (author)
- Sund, Christian (author)
- Zhou, Xiao- Xiong (author)
- Wahling, Horst (author)
- Pelcman, Michael (author)
- Agback, Tatiana (author)
- Benckestock, Kurt (author)
- Wikström, Kristina (author)
- Boothee, Mirva (author)
- Lindqvist, Anneli (author)
- Rydegard, Christina (author)
- Jonckers, Tim H. M. (author)
- Vandyck, Koen (author)
- Raboisson, Pierre (author)
- Lin, Tse-I (author)
- Lachau-Durand, Sophie (author)
- de Kock, Herman (author)
- Smith, David B. (author)
- Martin, Joseph A. (author)
- Klumpp, Klaus (author)
- Simmen, Kenneth (author)
- Vrang, Lotta (author)
- Terelius, Ylva (author)
- Samuelsson, Bertil (author)
- Rosenquist, Åsa (author)
- Johansson, Nils Gunnar (author)
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- (creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
- In: Bioorganic & Medicinal Chemistry Letters. - : Elsevier BV. - 0960-894X .- 1464-3405. ; 22:9, s. 3265-3268
- Journal article (peer-reviewed)
Abstract
Subject headings
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- 4'-Azido-2'-deoxy-2'-methylcytidine (14) is a potent nucleoside inhibitor of the HCV NS5B RNA-dependent RNA polymerase, displaying an EC50 value of 1.2 mu M and showing moderate in vivo bioavailability in rat (F = 14%). Here we describe the synthesis and biological evaluation of 4'-azido-2'-deoxy-2'-methylcytidine and prodrug derivatives thereof. (C) 2012 Elsevier Ltd. All rights reserved.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- hepatitis c virus
- ns5b polymerase
- antivirals
- nucleoside
- prodrug
- phosphoramidate
- genotype 1 infection
- antiviral activity
- viral-hepatitis
- analogs
- design
- 4'-azidocytidine
- boceprevir
- telaprevir
- resistance
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Bioorganic & Medicinal Chemistry Letters (Search for host publication in LIBRIS)
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- Nilsson, Magnus
- Kalayanov, Genad ...
- Winqvist, Anna
- Pinho, Pedro
- Sund, Christian
- Zhou, Xiao- Xion ...
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- Wahling, Horst
- Belfrage, Anna K ...
- Pelcman, Michael
- Agback, Tatiana
- Benckestock, Kur ...
- Wikström, Kristi ...
- Boothee, Mirva
- Lindqvist, Annel ...
- Rydegard, Christ ...
- Jonckers, Tim H. ...
- Vandyck, Koen
- Raboisson, Pierr ...
- Lin, Tse-I
- Lachau-Durand, S ...
- de Kock, Herman
- Smith, David B.
- Martin, Joseph A ...
- Klumpp, Klaus
- Simmen, Kenneth
- Vrang, Lotta
- Terelius, Ylva
- Samuelsson, Bert ...
- Rosenquist, Åsa
- Johansson, Nils ...
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- NATURAL SCIENCES
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- Uppsala University
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