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Blood group glycosp...
Blood group glycosphingolipid expression in kidney of an individual with the rare blood group A1 Le(a-b+) p phenotype: absence of blood group structures based on the globoseries.
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Lindström, K (författare)
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Jovall, Per-Åke (författare)
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Ghardashkani, S (författare)
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visa fler...
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Samuelsson, B E (författare)
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- Breimer, Michael, 1951 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för kirurgi,Institute of Surgical Sciences, Department of Surgery
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visa färre...
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(creator_code:org_t)
- 1996
- 1996
- Engelska.
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Ingår i: Glycoconjugate journal. - 0282-0080. ; 13:2, s. 307-13
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- Total neutral glycolipid fractions were isolated from kidney and ureter tissue obtained at autopsy of an individual of the rare blood group A1 Le(a-b+) p. The amount of glycolipids isolated were 3.7 and 2.5 mg g-1 dry tissue weight for the kidney and ureter tissue, which is in the range of reference blood group P kidneys. Part of the kidney glycolipid fraction was subfractionated by HPLC. Glycolipid compounds were structurally characterized by thin-layer chromatography (chemical detection and immunostaining with monoclonal antibodies), proton NMR spectroscopy and mass spectrometry. Globotriaosyl- and globotetraosyl-ceramides, which are the major compounds in kidneys of P individuals, were absent in the p kidney, and a comparatively increased amount of monoglycosyl- and lactosylceramides was found. A shift to longer fatty acyl chains in the ceramide part of lactosylceramides was noted. Elongated globoseries compounds with five to seven sugar residues, including the blood group A type 4 chain structure, were lacking. A slight increase in neolactotetraosyl- and blood group X pentaglycosyl-ceramides was noticed. The study confirms an enzymatic block in the conversion of lactosylceramide to elongated globoseries compounds in the kidney tissue similar to that of erythrocytes of p individuals.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Animals
- Antibodies
- Monoclonal
- Antibody Specificity
- Blood Group Antigens
- biosynthesis
- chemistry
- Chromatography
- High Pressure Liquid
- Chromatography
- Thin Layer
- Female
- Globosides
- biosynthesis
- chemistry
- Glycolipids
- biosynthesis
- chemistry
- isolation & purification
- Glycosphingolipids
- biosynthesis
- chemistry
- isolation & purification
- Humans
- Kidney
- chemistry
- metabolism
- Magnetic Resonance Spectroscopy
- Mass Spectrometry
- Mice
- P Blood-Group System
- genetics
- Phenotype
- Ureter
- chemistry
- metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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