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IL-9 Governs Allerg...
IL-9 Governs Allergen-induced Mast Cell Numbers in the Lung and Chronic Remodeling of the Airways
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Kearley, Jennifer (författare)
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- Erjefält, Jonas (författare)
- Lund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,Airway Inflammation and Immunology,Lund University Research Groups
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- Andersson, Cecilia (författare)
- Lund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,Airway Inflammation and Immunology,Lund University Research Groups
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Benjamin, Ebony (författare)
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Jones, Carla P. (författare)
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Robichaud, Annette (författare)
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Pegorier, Sophie (författare)
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Brewah, Yambasu (författare)
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Burwell, Timothy J. (författare)
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- Bjermer, Leif (författare)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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Kiener, Peter A. (författare)
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Kolbec, Roland (författare)
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Lloyd, Clare M. (författare)
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Coyle, Anthony J. (författare)
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Humbles, Alison A. (författare)
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(creator_code:org_t)
- 2011
- 2011
- Engelska.
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Ingår i: American Journal of Respiratory and Critical Care Medicine. - 1535-4970. ; 183:7, s. 865-875
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Rationale: IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as numerous hematopoietic cells, which are central to the pathogenesis of asthma. Objectives: The contribution of IL-9 to asthma pathogenesis has thus far been unclear, due to conflicting reports in the literature. These earlier studies focused on the role of IL-9 in acute inflammatory models; here we have investigated the effects of IL-9 blockade during chronic allergic inflammation. Methods: Mice were exposed to either prolonged ovalbumin or house dust mite allergen challenge to induce chronic inflammation and airway remodeling. Measurements and Main Results: We found that IL-9 governs allergen-induced mast cell (MC) numbers in the lung and has pronounced effects on chronic allergic inflammation. Anti-IL-9 antibody-treated mice were protected from airway remodeling with a concomitant reduction in mature MC numbers and activation, in addition to decreased expression of the profibrotic mediators transforming growth factor-beta 1, vascular endothelial growth factor, and fibroblast growth factor-2 in the lung. Airway remodeling was associated with impaired lung function in the peripheral airways and this was reversed by IL-9 neutralization. In human asthmatic lung tissue, we identified MCs as the main IL-9 receptor expressing population and found them to be sources of vascular endothelial growth factor and fibroblast growth factor-2. Conclusions: Our data suggest an important role for an IL-9-MC axis in the pathology associated with chronic asthma and demonstrate that an impact on this axis could lead to a reduction in chronic inflammation and improved lung function in patients with asthma.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- IL-9
- mast cells
- asthma
- airway remodeling
- AHR
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Kearley, Jennife ...
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Erjefält, Jonas
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Andersson, Cecil ...
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Benjamin, Ebony
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Jones, Carla P.
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Robichaud, Annet ...
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visa fler...
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Pegorier, Sophie
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Brewah, Yambasu
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Burwell, Timothy ...
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Bjermer, Leif
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Kiener, Peter A.
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Kolbec, Roland
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Lloyd, Clare M.
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Coyle, Anthony J ...
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Humbles, Alison ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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Lunds universitet