Body Mass Index and the Risk for Crohn's Disease and Ulcerative Colitis: Data From a European Prospective Cohort Study (The IBD in EPIC Study)

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Fältnamn	Indikatorer	Metadata
000		04878naa a2200625 4500
001		oai:DiVA.org:umu-73584
003		SwePub
008		130625s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:5071a4da-9b58-43b1-9017-2f9ff0b8da9b
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-735842 URI
024	7	a https://doi.org/10.1038/ajg.2012.4532 DOI
024	7	a https://lup.lub.lu.se/record/39355612 URI
040		a (SwePub)umud (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Chan, Simon S. M.4 aut
245	1 0	a Body Mass Index and the Risk for Crohn's Disease and Ulcerative Colitis :b Data From a European Prospective Cohort Study (The IBD in EPIC Study)
264	1	a New York, NY, USA :b Nature Publishing Group,c 2013
338		a print2 rdacarrier
520		a OBJECTIVES: Obesity is associated with a proinflammatory state that may be involved in the etiology of inflammatory bowel disease (IBD), for which there are plausible biological mechanisms. Our aim was to perform the first prospective cohort study investigating if there is an association between obesity and the development of incident IBD. METHODS: A total of 300,724 participants were recruited into the European Prospective Investigation into Cancer and Nutrition study. At recruitment, anthropometric measurements of height and weight plus physical activity and total energy intake from validated questionnaires were recorded. The cohort was monitored identifying participants who developed either Crohn's disease (CD) or ulcerative colitis (UC). Each case was matched with four controls and conditional logistic regression used to calculate odds ratios (ORs) for body mass index (BMI) adjusted for smoking, energy intake, and physical activity. RESULTS: In the cohort, 177 participants developed incident UC and 75 participants developed incident CD. There were no associations with the four higher categories of BMI compared with a normal BMI for UC (P-trend = 0.36) or CD (P-trend = 0.83). The lack of associations was consistent when BMI was analyzed as a continuous or binary variable (BMI 18.5 <25.0 vs. >= 25 kg/m(2)). Physical activity and total energy intake, factors that influence BMI, did not show any association with UC (physical activity, P-trend = 0.79; total energy intake, P-trend = 0.18) or CD (physical activity, P-trend = 0.42; total energy, P-trend = 0.11). CONCLUSIONS: Obesity as measured by BMI is not associated with the development of incident UC or CD. Alternative measures of obesity are required to further investigate the role of obesity in the development of incident IBD.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
700	1	a Luben, Robert4 aut
700	1	a Olsen, Anja4 aut
700	1	a Tjonneland, Anne4 aut
700	1	a Kaaks, Rudolf4 aut
700	1	a Teucher, Birgit4 aut
700	1	a Lindgren, Stefanu Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups4 aut0 (Swepub:lu)medf-sli
700	1	a Grip, Olofu Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups4 aut0 (Swepub:lu)medf-ogr
700	1	a Key, Timothy4 aut
700	1	a Crowe, Francesca L.4 aut
700	1	a Bergmann, Manuela M.4 aut
700	1	a Boeing, Heiner4 aut
700	1	a Hallmans, Göran,d 1947-u Umeå universitet,Näringsforskning,Enheten för biobanksforskning4 aut0 (Swepub:umu)goha0001
700	1	a Karling, Pontusu Umeå universitet,Medicin,GI Unit4 aut0 (Swepub:umu)peakag84
700	1	a Overvad, Kim4 aut
700	1	a Palli, Domenico4 aut
700	1	a Masala, Giovanna4 aut
700	1	a Kennedy, Hugh4 aut
700	1	a vanSchaik, Fiona4 aut
700	1	a Bueno-de-Mesquita, Bas4 aut
700	1	a Oldenburg, Bas4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Riboli, Elio4 aut
700	1	a Hart, Andrew R.4 aut
710	2	a Gastroenterologib Forskargrupper vid Lunds universitet4 org
773	0	t American Journal of Gastroenterologyd New York, NY, USA : Nature Publishing Groupg 108:4, s. 575-582q 108:4<575-582x 0002-9270x 1572-0241
856	4	u http://dx.doi.org/10.1038/ajg.2012.453y FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-73584
856	4 8	u https://doi.org/10.1038/ajg.2012.453
856	4 8	u https://lup.lub.lu.se/record/3935561

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