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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006157naa a2200961 4500
001oai:DiVA.org:umu-76728
003SwePub
008130712s2013 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:477bcf35-f230-4566-9ffc-8a77eba20468
009oai:prod.swepub.kib.ki.se:126879028
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-767282 URI
0247 a https://doi.org/10.1093/carcin/bgt0452 DOI
0247 a https://lup.lub.lu.se/record/39831152 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1268790282 URI
040 a (SwePub)umud (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Agudo, Antonio4 aut
2451 0a Hemochromatosis (HFE) gene mutations and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
264 c 2013-02-06
264 1b Oxford University Press,c 2013
338 a print2 rdacarrier
520 a Hereditary hemochromatosis (HH) is a strong risk factor for hepatocellular cancer, and mutations in the HFE gene associated with HH and iron overload may be related to other tumors, but no studies have been reported for gastric cancer (GC). A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC), including 365 incident gastric adenocarcinoma and 1284 controls matched by center, sex, age and date of blood collection. Genotype analysis was performed for two functional polymorphisms (C282Y/rs1800562 and H63D/rs1799945) and seven tagSNPs of the HFE genomic region. Association with all gastric adenocarcinoma, and according to anatomical localization and histological subtype, was assessed by means of the odds ratio (OR) and 95% confidence interval (CI) estimated by unconditional logistic regression adjusted for the matching variables. We observed a significant association for H63D with OR (per rare allele) of 1.32 (CI = 1.03-1.69). In subgroup analyses, the association was stronger for non-cardia anatomical subsite (OR = 1.60, CI = 1.16-2.21) and intestinal histological subtype (OR = 1.82, CI = 1.27-2.62). Among intestinal cases, two tagSNPs (rs1572982 and rs6918586) also showed a significant association that disappeared after adjustment for H63D. No association with tumors located in the cardia or with diffuse subtype was found for any of the nine SNPs analyzed. Our results suggest that H63D variant in HFE gene seems to be associated with GC risk of the non-cardia region and intestinal type, possibly due to its association with iron overload although a role for other mechanisms cannot be entirely ruled out.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi0 (SwePub)303012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Health Care Service and Management, Health Policy and Services and Health Economy0 (SwePub)303012 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
7001 a Bonet, Catalina4 aut
7001 a Sala, Núria4 aut
7001 a Muñoz, Xavier4 aut
7001 a Aranda, Núria4 aut
7001 a Fonseca-Nunes, Ana4 aut
7001 a Clavel-Chapelon, Françoise4 aut
7001 a Boutron-Ruault, Marie Christine4 aut
7001 a Vineis, Paolo4 aut
7001 a Panico, Salvatore4 aut
7001 a Palli, Domenico4 aut
7001 a Tumino, Rosario4 aut
7001 a Grioni, Sara4 aut
7001 a Quirós, J Ramón4 aut
7001 a Molina, Esther4 aut
7001 a Navarro, Carmen4 aut
7001 a Barricarte, Aurelio4 aut
7001 a Chamosa, Saioa4 aut
7001 a Allen, Naomi E4 aut
7001 a Khaw, Kay-Tee4 aut
7001 a Bueno-de-Mesquita, H Bas4 aut
7001 a Siersema, Peter D4 aut
7001 a Numans, Mattijs E4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Lagiou, Pagona4 aut
7001 a Trichopoulos, Dimitrios4 aut
7001 a Kaaks, Rudof4 aut
7001 a Canzian, Federico4 aut
7001 a Boeing, Heiner4 aut
7001 a Meidtner, Karina4 aut
7001 a Johansson, Mattiasu Umeå universitet,Medicinska fakulteten,WHO, IARC, Lyon, France4 aut
7001 a Sund, Malin,d 1972-u Umeå universitet,Kirurgi4 aut0 (Swepub:umu)masu0021
7001 a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)smi-jma
7001 a Overvad, Kim4 aut
7001 a Tjonneland, Anne4 aut
7001 a Lund, Eiliv4 aut
7001 a Weiderpass, Elisabeteu Karolinska Institutet4 aut
7001 a Jenab, Mazda4 aut
7001 a Fedirko, Veronika4 aut
7001 a Offerhaus, G Johan A4 aut
7001 a Riboli, Elio4 aut
7001 a González, Carlos A4 aut
7001 a Jakszyn, Paula4 aut
7102 a Umeå universitetb Medicinska fakulteten4 org
7730 t Carcinogenesisd : Oxford University Pressg 34:6, s. 1244-1250q 34:6<1244-1250x 0143-3334x 1460-2180
8564 u https://academic.oup.com/carcin/article-pdf/34/6/1244/7453738/bgt045.pdf
8564 u http://dx.doi.org/10.1093/carcin/bgt045y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-76728
8564 8u https://doi.org/10.1093/carcin/bgt045
8564 8u https://lup.lub.lu.se/record/3983115
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:126879028

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