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  • Gjesdal, GrundeLund University,Lunds universitet,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Lund University Research Groups,Skåne University Hospital (författare)

Validation of cause of death classification after heart transplantation and cause-specific life expectancy compared to the general population

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-06-28
  • Wiley,2022

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:8fd8c4ad-869f-448a-9071-81fa9e948544
  • https://lup.lub.lu.se/record/8fd8c4ad-869f-448a-9071-81fa9e948544URI
  • https://doi.org/10.1111/ctr.14756DOI
  • https://gup.ub.gu.se/publication/317277URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background: Post heart-transplant survival has increased, but information is lacking on specific causes of death and life expectancy. We aimed to assess cause-specific loss of life-years compared to the general population, evaluate classification for cause of death after heart transplantation, and assess validity of cause of death data from the International Society of Heart and Lung Transplant (ISHLT) registry. Methods: In this single center study, we included 239 heart recipients transplanted between 1988 and 2019 in Lund, Sweden (n = 239, 50% of the transplanted population where the cause of death was available). Two cardiologists retrospectively assigned causes of death according to a published classification (CLASS) in the 91 recipients who died during follow-up. Life expectancy was compared to data from the general population. Results: Compared to the average Swedish population, life expectancy for heart transplant recipients was 20 years shorter (IQR 12.9–27.2). The largest number of life-years lost were for deaths due to acute (49 years) and chronic rejection (27 years). Primary graft dysfunction (24 years) accounted for 24% of deaths, followed by malignancy (20 years) and infection (17 years), each accounting for ∼20% of deaths. Use of CLASS revealed moderate inter-rater agreement (56%) and moderate agreement with the ISHLT registry (62%). Conclusions: Survival after heart transplantation was 20 years lower than in the general population. In the young, more life-years were lost due to acute graft rejection, whereas chronic graft rejection and primary graft failure were more important causes of death in older patients. Agreement was moderate between CLASS and the ISHLT registry classifications.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lundgren, JakobLund University,Lunds universitet,Lund Hemodynamic Lab,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-jle (författare)
  • Czuba, TomaszGothenburg University,Göteborgs universitet,University of Gothenburg,Lund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Sahlgrenska University Hospital, Wallenberg Laboratory,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xczuto (författare)
  • Wareham, Neval EteCopenhagen University Hospital (författare)
  • Gustafsson, FinnCopenhagen University Hospital (författare)
  • Nilsson, JohanLund University,Lunds universitet,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Artificiell intelligens och bioinformatik inom thoraxkirurgisk vetenskap,Heart and Lung transplantation,Lund University Research Groups,Artificial Intelligence and Bioinformatics in Cardiothoracic Sciences (AIBCTS),Skåne University Hospital(Swepub:lu)thor-jni (författare)
  • Smith, J. GustavGothenburg University,Göteborgs universitet,University of Gothenburg,Lund University,Lunds universitet,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiovascular Epigenetics,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Sahlgrenska University Hospital,Sahlgrenska University Hospital, Wallenberg Laboratory,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xsmigu (författare)
  • Braun, OscarLund University,Lunds universitet,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kard-oos (författare)
  • Heart Failure and Mechanical SupportForskargrupper vid Lunds universitet (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Clinical Transplantation: Wiley36:90902-00631399-0012

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