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  • Micke, PatrickUppsala University,Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden (författare)

The prognostic impact of the tumour stroma fraction : A machine learning-based analysis in 16 human solid tumour types

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Elsevier,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-442108
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-442108URI
  • https://doi.org/10.1016/j.ebiom.2021.103269DOI
  • https://lup.lub.lu.se/record/ef273d09-5417-442b-98c1-c7a75955763bURI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:146238106URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-181740URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: The development of a reactive tumour stroma is a hallmark of tumour progression and pronounced tumour stroma is generally considered to be associated with clinical aggressiveness. The variability between tumour types regarding stroma fraction, and its prognosis associations, have not been systematically analysed.Methods: Using an objective machine-learning method we quantified the tumour stroma in 16 solid cancer types from 2732 patients, representing retrospective tissue collections of surgically resected primary tumours. Image analysis performed tissue segmentation into stromal and epithelial compartment based on pan-cytokeratin staining and autofluorescence patterns.Findings: The stroma fraction was highly variable within and across the tumour types, with kidney cancer showing the lowest and pancreato-biliary type periampullary cancer showing the highest stroma proportion (median 19% and 73% respectively). Adjusted Cox regression models revealed both positive (pancreato-biliary type periampullary cancer and oestrogen negative breast cancer, HR(95%CI)=0.56(0.34-0.92) and HR (95%CI)=0.41(0.17-0.98) respectively) and negative (intestinal type periampullary cancer, HR(95%CI)=3.59 (1.49-8.62)) associations of the tumour stroma fraction with survival.Interpretation: Our study provides an objective quantification of the tumour stroma fraction across major types of solid cancer. Findings strongly argue against the commonly promoted view of a general associations between high stroma abundance and poor prognosis. The results also suggest that full exploitation of the prognostic potential of tumour stroma requires analyses that go beyond determination of stroma abundance.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Strell, CarinaUppsala University,Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden(Swepub:uu)carst810 (författare)
  • Mattsson, Johanna Sofia Margareta,1985-Uppsala University,Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden(Swepub:uu)johma961 (författare)
  • Martin-Bernabe, AlfonsoKarolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.,Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden (författare)
  • Brunnström, HansLund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Department of Clinical Sciences Lund, Division of Pathology, Lund University, Lund, Sweden; Department of Genetics and Pathology, Division of Laboratory Medicine, Region Skåne, Lund, Sweden,Lund Univ, Dept Clin Sci Lund, Div Pathol, Lund, Sweden.;Dept Genet & Pathol, Div Lab Med, Lund, Sweden.(Swepub:lu)med-hsb (författare)
  • Huvila, JuttaUniv British Columbia, Dept Pathol, Vancouver, BC, Canada.;Univ Turku, Dept Pathol, Turku, Finland.,Department of Pathology, University of British Columbia, Vancouver, Canada; Department of Pathology, University of Turku, Turku, Finland,University of Turku (författare)
  • Sund, MalinUmeå universitet,Umeå University,Umeå Univ, Dept Surg & Perioperat Sci Surg, Umeå, Sweden.,Enheten för biobanksforskning,Kirurgi(Swepub:umu)masu0021 (författare)
  • Wärnberg, FredrikSahlgrenska Univ Hosp Göteborg, Inst Clin Sci, Dept Surg, Gothenburg, Sweden.,Department of Surgery at Institute of Clinical Sciences, Sahlgrenska University Hospital Göteborg, Göteborg, Sweden (författare)
  • Ponten, FredrikUppsala University,Uppsala universitet,Klinisk och experimentell patologi,Fredrik Pontén,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden(Swepub:uu)fredpont (författare)
  • Glimelius, BengtUppsala University,Uppsala universitet,Experimentell och klinisk onkologi,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden(Swepub:uu)bengglim (författare)
  • Hrynchyk, InaCity Clin Pathologoanat Bur, Minsk, BELARUS.,City Clinical Pathologoanatomic Bureau, Minsk, Belarus (författare)
  • Mauchanski, SiarheiNN Alexandrov Natl Canc Ctr Belarus, Minsk 223040, BELARUS.,N.N. Alexandrov Research Institute of Oncology and Medical Radiology,N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus (författare)
  • Khelashvili, SalomeNN Alexandrov Natl Canc Ctr Belarus, Minsk 223040, BELARUS.,N.N. Alexandrov Research Institute of Oncology and Medical Radiology,N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus (författare)
  • Garcia-Vicien, GemmaCatalan Inst Oncol, Program Canc Therapeut Resistance, IDIBELL,ProCURE, Mol Mech & Expt Therapy Oncol Program ONCOBELL, Barcelona, Spain.,Bellvitge Biomedical Research Institute,ProCURE, Program Against Cancer therapeutic Resistance, Catalan Institute of Oncology, Molecular Mechanisms and Experimental Therapy in Oncology Program (ONCOBELL), IDIBELL, L'Hospitalet de Llobregat, Catalonia, Barcelona, Spain (författare)
  • Mollevi, David G.Catalan Inst Oncol, Program Canc Therapeut Resistance, IDIBELL,ProCURE, Mol Mech & Expt Therapy Oncol Program ONCOBELL, Barcelona, Spain.,ProCURE, Program Against Cancer therapeutic Resistance, Catalan Institute of Oncology, Molecular Mechanisms and Experimental Therapy in Oncology Program (ONCOBELL), IDIBELL, L'Hospitalet de Llobregat, Catalonia, Barcelona, Spain,Bellvitge Biomedical Research Institute (författare)
  • Edqvist, Per-Henrik DKarolinska Institutet,Uppsala University,Uppsala universitet,Experimentell och klinisk onkologi,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden(Swepub:uu)peedq227 (författare)
  • Reilly, Aine O.Karolinska Institute,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.,Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden (författare)
  • Corvigno, SaraUppsala University,Uppsala universitet,Institutionen för immunologi, genetik och patologi,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.,Karolinska University Hospital,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden (författare)
  • Dahlstrand, HannaUppsala University,Karolinska Institute,Uppsala universitet,Experimentell och klinisk onkologi,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden(Swepub:uu)handa983 (författare)
  • Botling, JohanUppsala University,Uppsala universitet,Klinisk och experimentell patologi,Johan Botling,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden(Swepub:uu)johanbot (författare)
  • Segersten, UlrikaUppsala University,Uppsala universitet,Urologkirurgi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)ulriande (författare)
  • Krzyzanowska, AgnieszkaLund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urological cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Dept Translat Med, Div Urol Canc, Lund, Sweden.,Department of Translational Medicine, Division of Urological Cancers, Lund University, Lund, Sweden(Swepub:lu)med-aky (författare)
  • Bjartell, AndersLund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urological cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Dept Translat Med, Div Urol Canc, Lund, Sweden.,Department of Translational Medicine, Division of Urological Cancers, Lund University, Lund, Sweden(Swepub:lu)kir-abj (författare)
  • Elebro, JacobLund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Clin Sci Lund, Div Oncol & Therapeut Pathol, SE-22100 Lund, Sweden.,Department of Clinical Sciences Lund, Division of Oncology and Therapeutic Pathology, Lund University, Lund, Sweden(Swepub:lu)med-jce (författare)
  • Heby, MargaretaLund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Dept Clin Sci Lund, Div Oncol & Therapeut Pathol, SE-22100 Lund, Sweden.,Department of Clinical Sciences Lund, Division of Oncology and Therapeutic Pathology, Lund University, Lund, Sweden(Swepub:lu)med-mh11 (författare)
  • Lundgren, SebastianLund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Dept Clin Sci Lund, Div Oncol & Therapeut Pathol, SE-22100 Lund, Sweden.,Department of Clinical Sciences Lund, Division of Oncology and Therapeutic Pathology, Lund University, Lund, Sweden(Swepub:lu)se2285lu (författare)
  • Hedner, CharlottaLund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Dept Clin Sci Lund, Div Oncol & Therapeut Pathol, SE-22100 Lund, Sweden.,Department of Clinical Sciences Lund, Division of Oncology and Therapeutic Pathology, Lund University, Lund, Sweden(Swepub:lu)med-cah (författare)
  • Borg, DavidLund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Dept Clin Sci Lund, Div Oncol & Therapeut Pathol, SE-22100 Lund, Sweden.,Department of Clinical Sciences Lund, Division of Oncology and Therapeutic Pathology, Lund University, Lund, Sweden(Swepub:lu)onk-dbo (författare)
  • Brändstedt, JennyLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Lund Univ, Dept Clin Sci Lund, Div Oncol & Therapeut Pathol, SE-22100 Lund, Sweden.,Department of Clinical Sciences Lund, Division of Oncology and Therapeutic Pathology, Lund University, Lund, Sweden(Swepub:lu)med-jyb (författare)
  • Sartor, HannaLund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Radiology Diagnostics, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Diagnostic Radiology, Department of Translational Medicine, Lund University, Skåne University Hospital, Lund, Sweden,Lund Univ, Skane Univ Hosp, Dept Translat Med, Diagnost Radiol, Lund, Sweden.(Swepub:lu)med-hso (författare)
  • Malmström, Per-UnoUppsala University,Uppsala universitet,Urologkirurgi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)perunoms (författare)
  • Johansson, MartinSahlgrenska Univ Hosp Göteborg, Inst Biomed, Dept Lab Med, Gothenburg, Sweden.,Department of Laboratory Medicine at Institute of Biomedicine, Sahlgrenska Universitety Hospital Göteborg, Göteborg, Sweden (författare)
  • Nodin, BjörnLund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Dept Clin Sci Lund, Div Oncol & Therapeut Pathol, SE-22100 Lund, Sweden.,Department of Clinical Sciences Lund, Division of Oncology and Therapeutic Pathology, Lund University, Lund, Sweden(Swepub:lu)immu-bnn (författare)
  • Backman, MaxUppsala University,Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden(Swepub:uu)maxba655 (författare)
  • Lindskog, CeciliaUppsala University,Uppsala universitet,Klinisk och experimentell patologi,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden(Swepub:uu)cecli129 (författare)
  • Jirström, KarinLund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Department of Genetics and Pathology, Division of Laboratory Medicine, Region Skåne, Lund, Sweden; Department of Clinical Sciences Lund, Division of Oncology and Therapeutic Pathology, Lund University, Lund, Sweden,Dept Genet & Pathol, Div Lab Med, Lund, Sweden.;Lund Univ, Dept Clin Sci Lund, Div Oncol & Therapeut Pathol, SE-22100 Lund, Sweden.(Swepub:lu)pat-kji (författare)
  • Mezheyeuski, ArturUppsala University,Uppsala universitet,Experimentell och klinisk onkologi,Uppsala Univ, Dept Immunol Genet & Pathol, S-75185 Uppsala, Sweden.,Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden(Swepub:uu)artme913 (författare)
  • Uppsala universitetKlinisk och experimentell patologi (creator_code:org_t)

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  • Ingår i:EBioMedicine: Elsevier652352-3964

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