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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007505naa a2200613 4500
001oai:DiVA.org:his-24392
003SwePub
008240717s2024 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-228011
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-243922 URI
0247 a https://doi.org/10.1016/j.tranon.2024.1020592 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2280112 URI
040 a (SwePub)hisd (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Borgmästars, Emmyu Umeå universitet,Institutionen för diagnostik och intervention,Kirurgi4 aut0 (Swepub:umu)embo0061
2451 0a Multi-omics profiling to identify early plasma biomarkers in pre-diagnostic pancreatic ductal adenocarcinoma :b a nested case-control study
264 1b Elsevier,c 2024
338 a electronic2 rdacarrier
500 a CC BY 4.0Corresponding author at: University Hospital of Umeå, 901 85 Umeå, Sweden. E-mail address: emmy.borgmastars@umu.se (E. Borgmästars)The authors thank Hanna Nyström, and Daniel Öhlund at Umeå University for valuable assistance in data collection. We thank Xiaoshuang Feng at International Agency for Research of Cancer, Lyon, France for guidance in statistical analyses. The authors would also like to thank Swedish Metabolomics Centre, Umeå, Sweden (www.swedishmetabolomicscentre.se) and Biobanken Norr. Funding: This study was funded by Umeå University, the Swedish Research Council [2016-02990, 2019-01690], the Swedish Cancer Society [CAN 2016/643, 19 0273], Region Västerbotten [RV-583411, RV-549731, RV-583411, RV-841551, RV 967602], Finska Läkaresällskapet, Medicinska Understödsföreningen Liv och Hälsa, the Sjöberg Foundation, The JC Kempe Memorial Foundation Scholarship Fund, The Royal Swedish Academy of Sciences (PE Lindahl Foundation, LM2021-0010 and LM2023-0012), The Swedish Society of Medicine (SLS-960379), Cancerforskningsfonden i Norrland (LP 23-2337), Bengt Ihre foundation (SLS-960529 and SLS-986656), and Bengt Ihre Research Fellowship Grant. The sponsors had no role in the study design, collection, analysis and interpretation of data, writing of the report, or in the decision to submit the article for publication.
520 a Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor survival. Novel biomarkers are urgently needed to improve the outcome through early detection. Here, we aimed to discover novel biomarkers for early PDAC detection using multi-omics profiling in pre-diagnostic plasma samples biobanked after routine health examinations.A nested case-control study within the Northern Sweden Health and Disease Study was designed. Pre-diagnostic plasma samples from 37 future PDAC patients collected within 2.3 years before diagnosis and 37 matched healthy controls were included. We analyzed metabolites using liquid chromatography mass spectrometry and gas chromatography mass spectrometry, microRNAs by HTG edgeseq, proteins by multiplex proximity extension assays, as well as three clinical biomarkers using milliplex technology. Supervised and unsupervised multi-omics integration were performed as well as univariate analyses for the different omics types and clinical biomarkers. Multiple hypothesis testing was corrected using Benjamini-Hochberg's method and a false discovery rate (FDR) below 0.1 was considered statistically significant.Carbohydrate antigen (CA) 19-9 was associated with PDAC risk (OR [95 % CI] = 3.09 [1.31–7.29], FDR = 0.03) and increased closer to PDAC diagnosis. Supervised multi-omics models resulted in poor discrimination between future PDAC cases and healthy controls with obtained accuracies between 0.429–0.500. No single metabolite, microRNA, or protein was differentially altered (FDR < 0.1) between future PDAC cases and healthy controls.CA 19-9 levels increase up to two years prior to PDAC diagnosis but extensive multi-omics analysis including metabolomics, microRNAomics and proteomics in this cohort did not identify novel early biomarkers for PDAC.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng
650 7a NATURVETENSKAPx Data- och informationsvetenskapx Bioinformatik0 (SwePub)102032 hsv//swe
650 7a NATURAL SCIENCESx Computer and Information Sciencesx Bioinformatics0 (SwePub)102032 hsv//eng
653 a Pancreatic neoplasms
653 a miRNomics
653 a Metabolomics
653 a Proteomics
653 a Risk
653 a Bioinformatik
653 a Bioinformatics
7001 a Ulfenborg, Benjamin,d 1985-u Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Translational Bioinformatics,School of Bioscience, Department of Biology and Bioinformatics, University of Skövde, Skövde, Sweden4 aut0 (Swepub:his)ulfb
7001 a Johansson, Mattiasu Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France4 aut
7001 a Jonsson, Päru Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)parjon95
7001 a Billing, Ola,d 1981-u Umeå universitet,Institutionen för diagnostik och intervention,Kirurgi4 aut0 (Swepub:umu)olabig00
7001 a Franklin, Oskar,d 1985-u Umeå universitet,Institutionen för diagnostik och intervention,Kirurgi,Division of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, CO, Aurora, United States4 aut0 (Swepub:umu)osfr0002
7001 a Lundin, Christina,d 1970-u Umeå universitet,Institutionen för diagnostik och intervention,Kirurgi4 aut0 (Swepub:umu)chlu0008
7001 a Jacobson, Sarau Umeå universitet,Institutionen för diagnostik och intervention,Kirurgi4 aut0 (Swepub:umu)saja0030
7001 a Simm, Majau Umeå universitet,Institutionen för diagnostik och intervention,Obstetrik och gynekologi,Kirurgi4 aut0 (Swepub:umu)makr0062
7001 a Lubovac-Pilav, Zelminau Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Translational Bioinformatics,School of Bioscience, Department of Biology and Bioinformatics, University of Skövde, Skövde, Sweden4 aut0 (Swepub:his)lubz
7001 a Sund, Malinu Umeå universitet,Institutionen för diagnostik och intervention,Kirurgi,Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland4 aut0 (Swepub:umu)masu0021
7102 a Umeå universitetb Institutionen för diagnostik och intervention4 org
7730 t Translational Oncologyd : Elsevierg 48q 48x 1944-7124x 1936-5233
8564 u https://doi.org/10.1016/j.tranon.2024.102059y Fulltext
8564 u https://his.diva-portal.org/smash/get/diva2:1884505/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
8564 u https://umu.diva-portal.org/smash/get/diva2:1885143/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-24392
8564 8u https://doi.org/10.1016/j.tranon.2024.102059
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-228011

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