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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02712naa a2200481 4500 | |
| 001 | oai:DiVA.org:uu-144617 | |
| 003 | SwePub | |
| 008 | 110201s2008 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1446172 URI |
| 024 | 7 | a https://doi.org/10.1126/science.11596892 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Brouns, Stan J4 aut |
| 245 | 1 0 | a Small CRISPR RNAs guide antiviral defense in prokaryotes |
| 264 | 1 | b American Association for the Advancement of Science (AAAS),c 2008 |
| 338 | a print2 rdacarrier | |
| 520 | a Prokaryotes acquire virus resistance by integrating short fragments of viral nucleic acid into clusters of regularly interspaced short palindromic repeats (CRISPRs). Here we show how virus-derived sequences contained in CRISPRs are used by CRISPR-associated (Cas) proteins from the host to mediate an antiviral response that counteracts infection. After transcription of the CRISPR, a complex of Cas proteins termed Cascade cleaves a CRISPR RNA precursor in each repeat and retains the cleavage products containing the virus-derived sequence. Assisted by the helicase Cas3, these mature CRISPR RNAs then serve as small guide RNAs that enable Cascade to interfere with virus proliferation. Our results demonstrate that the formation of mature guide RNAs by the CRISPR RNA endonuclease subunit of Cascade is a mechanistic requirement for antiviral defense. | |
| 653 | a CRISPR | |
| 653 | a NATURAL SCIENCES | |
| 653 | a NATURVETENSKAP | |
| 653 | a Mikrobiologi | |
| 653 | a Microbiology | |
| 653 | a Biokemi | |
| 653 | a Biochemistry | |
| 653 | a Genetics | |
| 653 | a Genetik | |
| 700 | 1 | a Jore, Matthijs M4 aut |
| 700 | 1 | a Lundgren, Magnus,d 1975-u Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University4 aut0 (Swepub:uu)malun031 |
| 700 | 1 | a Westra, Edze R4 aut |
| 700 | 1 | a Slijkhuis, Rik J4 aut |
| 700 | 1 | a Snijders, Ambrosius P4 aut |
| 700 | 1 | a Dickman, Mark J4 aut |
| 700 | 1 | a Makarova, Kira S4 aut |
| 700 | 1 | a Koonin, Eugene V4 aut |
| 700 | 1 | a Van Der Oost, John4 aut |
| 710 | 2 | a Laboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University4 org |
| 773 | 0 | t Scienced : American Association for the Advancement of Science (AAAS)g 321:5891, s. 960-964q 321:5891<960-964x 0036-8075x 1095-9203 |
| 856 | 4 | u https://europepmc.org/articles/pmc5898235?pdf=render |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-144617 |
| 856 | 4 8 | u https://doi.org/10.1126/science.1159689 |
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