WFRF:(Matuszewski Damian J.)
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PopulationProfiler : A Tool for Population Analysis and Visualization of Image-Based Cell Screening Data
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- Matuszewski, Damian J. (author)
- Uppsala universitet,Avdelningen för visuell information och interaktion,Bildanalys och människa-datorinteraktion,Science for Life Laboratory, SciLifeLab
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- Wählby, Carolina (author)
- Uppsala universitet,Avdelningen för visuell information och interaktion,Bildanalys och människa-datorinteraktion,Science for Life Laboratory, SciLifeLab
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- Carreras-Puigvert, Jordi (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Biochem & Biophys, Div Translat Med & Chem Biol, Stockholm, Sweden; ] Sci Life Lab, Stockholm, Sweden
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- (creator_code:org_t)
- 2016-03-17
- 2016
- English.
- In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:3
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Image-based screening typically produces quantitative measurements of cell appearance. Large-scale screens involving tens of thousands of images, each containing hundreds of cells described by hundreds of measurements, result in overwhelming amounts of data. Reducing per-cell measurements to the averages across the image(s) for each treatment leads to loss of potentially valuable information on population variability. We present PopulationProfiler-a new software tool that reduces per-cell measurements to population statistics. The software imports measurements from a simple text file, visualizes population distributions in a compact and comprehensive way, and can create gates for subpopulation classes based on control samples. We validate the tool by showing how PopulationProfiler can be used to analyze the effect of drugs that disturb the cell cycle, and compare the results to those obtained with flow cytometry.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
Keyword
- Computerized Image Processing
- Datoriserad bildbehandling
Publication and Content Type
- ref (subject category)
- art (subject category)
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