Cerebellar grey matter modifications in lower limb amputees not using prosthesis

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Fältnamn	Indikatorer	Metadata
000		02443naa a2200349 4500
001		oai:prod.swepub.kib.ki.se:137412844
003		SwePub
008		240913s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1374128442 URI
024	7	a https://doi.org/10.1038/s41598-017-18772-22 DOI
040		a (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Di Vita, A4 aut
245	1 0	a Cerebellar grey matter modifications in lower limb amputees not using prosthesis
264		c 2018-01-10
264	1	b Springer Science and Business Media LLC,c 2018
520		a Plastic brain changes following peripheral deafferentation, in particular those following limb amputations, are well-documented, with significant reduction of grey matter (GM) in the sensory-motor cerebral areas representing the amputated limb. However, few studies have investigated the role played by the use of a prosthesis in these structural brain modifications. Here we hypothesized that using a functional prosthesis that allows individuals to perform actions may reduce grey matter reduction. We investigated the brain structural reorganization following lower limb amputation by using a Voxel Based Morphometry (VBM) analysis of structural magnetic resonance imaging (MRI) in 8 right-handed individuals with lower limb amputation (LLA) fitted with prostheses (LLAwp), compared to 6 LLA who had never used a prosthesis (LLAnp). 14 age-matched healthy controls were also enrolled (HC). We did not find any significant effect when comparing LLAwp and HC. However we found a decreased GM volume in the bilateral cerebellum in LLAnp compared with HC. These results suggest that prosthesis use prevents GM decrease in the cerebellum after lower limb amputation.
700	1	a Boccia, M4 aut
700	1	a Palermo, L4 aut
700	1	a Nemmi, F4 aut
700	1	a Traballesi, M4 aut
700	1	a Brunelli, S4 aut
700	1	a De Giorgi, R4 aut
700	1	a Galati, G4 aut
700	1	a Guariglia, C4 aut
773	0	t Scientific reportsd : Springer Science and Business Media LLCg 8:1, s. 370-q 8:1<370-x 2045-2322
856	4	u https://www.nature.com/articles/s41598-017-18772-2.pdf
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:137412844
856	4 8	u https://doi.org/10.1038/s41598-017-18772-2

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Av författaren/redakt...: Di Vita, A; Boccia, M; Palermo, L; Nemmi, F; Traballesi, M; Brunelli, S; visa fler...; De Giorgi, R; Galati, G; Guariglia, C; visa färre...

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