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Quantitative assessment of the subepithelial collagen band does not increase the accuracy of diagnosis of collagenous colitis

Rubio, Carlos A. (author)
Karolinska Institutet
Orrego, Abiel (author)
Höög, Anders (author)
Karolinska Institutet
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Porwitz, Anja (author)
Petersson, Fredrik (author)
Elmberger, Göran (author)
Karolinska Institutet
Glaessgen, Axel (author)
Eriksson, Elina (author)
Kanter, Lena (author)
Karolinska Institutet
Jaremko, Georg (author)
Karolinska Institutet
Egevad, Lars (author)
Karolinska Institutet
Laforga, Juan (author)
Liljefors, M. (author)
Karolinska Institutet
Löfdahl, Britta (author)
Uppsala universitet,Institutionen för genetik och patologi
Norman, Peter (author)
Larsson, Olle (author)
Karolinska Institutet
Wanat, Robert (author)
Wejde, Johan (author)
Zickert, Peter (author)
Björk, Jan (author)
Karolinska Institutet
Caini, Saverio (author)
Palli, Domenico (author)
Nesi, Gabriella (author)
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 (creator_code:org_t)
2008
2008
English.
In: American Journal of Clinical Pathology. - 0002-9173 .- 1943-7722. ; 130:3, s. 375-381
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The thickness of eosinophilic band in collagenous colitis (CC) was assessed by 3 methods: histologic estimates (22 observers), conventional measurements using a calibrated micrometric scale (1 observer), and semiautomatic micrometric measurements (1 observer). By the histologic estimate technique, 7.4% of the results failed to diagnose CC; by calibrated micrometry, the failure was 6% and by semiautomatic micrometry, 6%. The main difficulty in measuring the thickness of the CC band is that the deeper border of the band appears fuzzy and hairy-irregular. CC should be defined not exclusively on the basis of the thickness of the collagen table, but as a microscopic constellation characterized by a distorted superficial cell arrangement, with areas of epithelial denudation and inflammatory cells in the superficial epithelium and the lamina propria. In agreement with Lazenby's statement: "Focusing solely on the collagen band can result in both over- and underdiagnosis"

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Keyword

collagenous colitis
Gastroenterology
Gastroenterologi
Pathology
Patologi
Pathology
Patologi

Publication and Content Type

ref (subject category)
art (subject category)

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