Pro-inflammatory modification of cancer cells microsurroundings increases the survival rates for rats with low differentiated malignant glioma of brain

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Pro-inflammatory modification of cancer cells microsurroundings increases the survival rates for rats with low differentiated malignant glioma of brain

Zaitsev, Sergei (author): Far Eastern Fed Univ, Sch Biomed, Dept Fundamental Med, Vladivostok, Russia.

Sharma, Hari Shanker (author): Uppsala universitet,Anestesiologi och intensivvård,Institutionen för medicinsk cellbiologi

Sharma, Aruna (author): Uppsala universitet,Anestesiologi och intensivvård

Manzhulo, Igor (author): Far Eastern Fed Univ, Sch Biomed, Dept Fundamental Med, Vladivostok, Russia.;Russian Acad Sci, Far East Branch, Natl Sci Ctr Marine Biol, Pharmacol Lab, Vladivostok, Russia.

Polevshchikov, Alexander (author): Inst Expt Med, Dept Immunol, St Petersburg, Russia.

Kudriavtsev, Igor (author): Inst Expt Med, Dept Immunol, St Petersburg, Russia.

Khotimchenko, Yuri (author): Far Eastern Fed Univ, Sch Biomed, Dept Fundamental Med, Vladivostok, Russia.;Russian Acad Sci, Far East Branch, Natl Sci Ctr Marine Biol, Pharmacol Lab, Vladivostok, Russia.

Pak, Oleg (author): Far Eastern Fed Univ, Med Ctr, Vladivostok, Russia.

Bryukhovetskiy, Andrey (author): NeuroVita Clin Intervent & Restorat Neurol & Ther, Moscow, Russia.

Bryukhovetskiy, Igor (author): Far Eastern Fed Univ, Sch Biomed, Dept Fundamental Med, Vladivostok, Russia.;Russian Acad Sci, Far East Branch, Natl Sci Ctr Marine Biol, Pharmacol Lab, Vladivostok, Russia.;Far Eastern Fed Univ, Med Ctr, Vladivostok, Russia.

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Far Eastern Fed Univ, Sch Biomed, Dept Fundamental Med, Vladivostok, Russia Anestesiologi och intensivvård (creator_code:org_t)

LONDON ENGLAND : Elsevier, 2020
2020
English.
In: NOVEL THERAPEUTIC ADVANCES IN GLIOBLASTOMA. - LONDON ENGLAND : Elsevier. - 9780128211144 ; , s. 253-279

Related links:: https://doi.org/10.1...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Book chapter (peer-reviewed)

Abstract Subject headings

Rationale: Glioblastoma multiforme (GBM) is one of the most aggressive human brain tumors. The prognosis is unfavorable with a median survival of 15 months. GBM aggressive nature is associated with a special phenotype of cancer cells that develops because of the transforming growth factor beta (TGF-beta). The study was aimed at providing experimental justification in vivo of a possibility to suppress TGF-beta production in a tumor via pro-inflammatory modification of cancer cell microenvironment, using CD45+ mononuclear cells of the red bone marrow. Materials and methods: The experiment used animals with transplanted C6 glioma. The animals were divided into 4 groups: (I) control (N = 60); (II) group of rats (N = 30) that received granulocyte colony-stimulating factor (G-CSF) to recruit CD45+ bone marrow mononuclear cells into their systemic circulation (G-CSF group); (III) group of rats (N = 30) that received pro-inflammatory therapy to trigger systemic inflammatory reaction by injecting bacterial lipopolysaccharides (LPS) and interferon-gamma (IFN gamma); (IV) rats (N = 30), stimulated with G-CSF, followed by pro-inflammatory therapy. Stereotaxic modeling of a brain tumor in experimental animals, as well as a combination of morphological, immunocytochemical analyses and immunosorbent assay were used. Results: TGF-beta 1 production in the tumor tissue resulted being inversely proportional to the intensity of proliferation processes and directly proportional to the size of necrosis areas, peaking on the 28th day of the experiment. Stimulation of experimental animals with G-CSF recruits CD45+ mononuclear stem and progenitor cells into the systemic circulation of experimental animals with C6 glioma, accompanied by intensification of microglial proliferation in the tumor and infiltration of the tumor tissue with microglial cells. Pro-inflammatory therapy against G-CSF stimulation results in polarization of microglia/macrophages population together with intensified antigen presentation, lower production of TGF-beta and IL10, increased synthesis of pro-inflammatory cytokines TNF alpha and IL1 in the tumor lesion and adjacent brain matter, remodeling of tumor matrix and higher survival rates for the experimental animals. Conclusions: Pro-inflammatory inflammatory modification of cancer cell microenvironment suppresses TGF beta production in a tumor and increases survival rates of the rats with transplanted poorly differentiated malignant brain glioma.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

HEMATOPOIETIC STEM-CELLS; TGF-BETA; GLIOBLASTOMA; MICROGLIA; MACROPHAGES; ANGIOGENESIS; MODULATION; EXPRESSION; HEALTH; VEGF

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

Articles in the publication: NOVEL THERAPEUTI ...

By the university: Uppsala University

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Pro-inflammatory modification of cancer cells microsurroundings increases the survival rates for rats with low differentiated malignant glioma of brain

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