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WFRF:(Palmqvist Erik)
 

Sökning: WFRF:(Palmqvist Erik) > Acute phase markers...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004132naa a2200433 4500
001oai:lup.lub.lu.se:dcc3c780-3c53-4b01-af0b-bb2b322ae07e
003SwePub
008201021s2021 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/dcc3c780-3c53-4b01-af0b-bb2b322ae07e2 URI
0247 a https://doi.org/10.1016/j.pneurobio.2020.1019042 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Ayton, Scottu University of Melbourne4 aut
2451 0a Acute phase markers in CSF reveal inflammatory changes in Alzheimer's disease that intersect with pathology, APOE ε4, sex and age
264 1b Elsevier BV,c 2021
520 a It is unknown how neuroinflammation may feature in the etiology of Alzheimer's disease (AD). We profiled acute phase response (APR) proteins (α1-antitrypsin, α1-antichymotrypsin, ceruloplasmin, complement C3, ferritin, α-fibrinogen, β-fibrinogen, γ-fibrinogen, haptoglobin, hemopexin) in CSF of 1291 subjects along the clinical and biomarker spectrum of AD to investigate the association between inflammatory changes, disease outcomes, and demographic variables. Subjects were stratified by Aβ42/t-tau as well as the following clinical diagnoses: cognitively normal (CN); subjective cognitive decline (SCD); mild cognitive impairment (MCI); and AD dementia. In separate multiple regressions (adjusting for diagnosis, age, sex, APOE-ε4) of each APR protein and a composite of all APR proteins, CSF Aβ42/t-tau status was associated with elevated ferritin, but not any other APR protein in CN and SCD subjects. Rather, the APR was elevated along with symptomatic progression (CN < SCD < MCI < AD), and this was elevation was mediated by CSF p-tau181. APOE ε4 status did not affect levels of any APR proteins in CSF, while these were elevated in males and with increased age. The performance of the APR in predicting clinical diagnosis was influenced by APOE ε4 status, sex, and age. These data provide new insight into inflammatory changes in AD and how this intersects with pathology changes and patient demographics.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a acute phase response
653 a Alzheimer's disease
653 a biomarkers
653 a Neuroinflammation
7001 a Janelidze, Shorenau Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)nkir-sje
7001 a Roberts, Blaineu University of Melbourne4 aut
7001 a Palmqvist, Sebastianu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-spa
7001 a Kalinowski, Pawelu University of Melbourne4 aut
7001 a Diouf, Ibrahimau University of Melbourne4 aut
7001 a Belaidi, Abdel A.u University of Melbourne4 aut
7001 a Stomrud, Eriku Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-esr
7001 a Bush, Ashley I.u University of Melbourne4 aut
7001 a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn
7102 a University of Melbourneb Klinisk minnesforskning4 org
7730 t Progress in Neurobiologyd : Elsevier BVg 198q 198x 0301-0082
8564 u http://dx.doi.org/10.1016/j.pneurobio.2020.101904y FULLTEXT
8564 8u https://lup.lub.lu.se/record/dcc3c780-3c53-4b01-af0b-bb2b322ae07e
8564 8u https://doi.org/10.1016/j.pneurobio.2020.101904

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