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Role of Alanine Racemase Mutations in Mycobacterium tuberculosis D-Cycloserine Resistance

Nakatani, Yoshio (author)
University of Otago, New Zealand; University of Auckland, New Zealand; University of Otago, New Zealand
Opel-Reading, Helen K. (author)
University of Otago, New Zealand
Merker, Matthias (author)
Research Centre Borstel, Germany; German Centre Infect Research, Germany
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Machado, Diana (author)
University of Nova Lisboa, Portugal
Andres, Sonke (author)
National TB Reference Lab, Germany
Siva Kumar, S. (author)
National Institute Research TB, India
Moradigaravand, Danesh (author)
Wellcome Trust Sanger Institute, England
Coll, Francesc (author)
London School Hyg and Trop Med, England
Perdigao, Joao (author)
University of Lisbon, Portugal
Portugal, Isabel (author)
University of Lisbon, Portugal
Schön, Thomas (author)
Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Kalmar County Hospital, Sweden
Nair, Dina (author)
National Institute Research TB, India
Uma Devi, K. R. (author)
National Institute Research TB, India
Kohl, Thomas A. (author)
Research Centre Borstel, Germany
Beckert, Patrick (author)
Research Centre Borstel, Germany; German Centre Infect Research, Germany
Clark, Taane G. (author)
London School Hyg and Trop Med, England
Maphalala, Gugu (author)
Minist Heatlh, Swaziland
Khumalo, Derrick (author)
Minist Heatlh, Swaziland
Diel, Roland (author)
University Hospital Schleswig Holstein, Germany
Klaos, Kadri (author)
Tartu University Hospital, Estonia
Lin Aung, Htin (author)
University of Otago, New Zealand; University of Auckland, New Zealand
Cook, Gregory M. (author)
University of Otago, New Zealand; University of Auckland, New Zealand
Parkhill, Julian (author)
Wellcome Trust Sanger Institute, England
Peacock, Sharon J. (author)
Wellcome Trust Sanger Institute, England; London School Hyg and Trop Med, England; University of Cambridge, England
Swaminathan, Soumya (author)
Indian Council Medical Research, India
Viveiros, Miguel (author)
University of Nova Lisboa, Portugal
Niemann, Stefan (author)
Research Centre Borstel, Germany; German Centre Infect Research, Germany
Krause, Kurt L. (author)
University of Auckland, New Zealand; University of Otago, New Zealand
Koser, Claudio U. (author)
University of Cambridge, England
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 (creator_code:org_t)
AMER SOC MICROBIOLOGY, 2017
2017
English.
In: Antimicrobial Agents and Chemotherapy. - : AMER SOC MICROBIOLOGY. - 0066-4804 .- 1098-6596. ; 61:12
Related links:
https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to D-cycloserine.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)

Keyword

Mycobacterium tuberculosis; cycloserine; alanine racemase

Publication and Content Type

ref (subject category)
art (subject category)

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