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Differential effect...
Differential effects of TGF-beta1 on telomerase activity in thyroid carcinoma cells
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- Lindkvist, Anna (författare)
- Uppsala universitet,Institutionen för genetik och patologi
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- Franzén, Åsa (författare)
- Uppsala universitet,Institutionen för genetik och patologi
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- Ren, Zhi-Ping (författare)
- Uppsala universitet,Institutionen för genetik och patologi
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- Heldin, Nils-Erik (författare)
- Uppsala universitet,Institutionen för genetik och patologi
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- Paulsson-Karlsson, Ylva (författare)
- Uppsala universitet,Institutionen för genetik och patologi
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(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- Engelska.
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Ingår i: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier BV. - 0006-291X .- 1090-2104. ; 338:3, s. 1625-1633
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The aim of the present study was to investigate the effect of transforming growth factor-beta1 (TGF-beta1) on telomerase activity in a panel of human anaplastic thyroid carcinoma (ATC) cell lines. Addition of TGF-beta1 decreased the telomerase activity in HTh 74 and KTC-1 cells, while in C 643 and HTh 7 an increased activity was observed. The decreased telomerase activity appeared to be due to transcriptional repression of the hTERT promoter. Addition of a PI-3 kinase inhibitor (LY294002) abrogated the stimulatory effect of TGF-beta1 on the telomerase activity, indicating the possible involvement of hTERT activation via phosphorylation. Furthermore, the MEK-inhibitor U0126 had similar effects suggesting dual regulatory mechanisms. Interestingly, the cell lines differed genetically in that ATC cell lines responding with increased telomerase activity harbored a p53 mutation. In conclusion, TGF-beta1 exerts opposing effects on telomerase activity in ATC cell lines, possibly reflecting deregulation of TGF-beta1 signaling in a more malignant genotype.
Nyckelord
- Anaplastic thyroid carcinoma
- c-Myc
- hTERT promoter
- p53
- Telomerase
- TGF-β1
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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