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Sökning: WFRF:(Pelechano Vicent) > Targeting MYC induc...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
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0247 a https://doi.org/10.1073/pnas.23104791212 DOI
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0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:2383352552 URI
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041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Sainero-Alcolado, Lourdesu Karolinska Institutet,Karolinska Institute,Department of Microbiology, Tumor and Cell Biology, Biomedicum B7, Karolinska Institutet, Stockholm 17165, Sweden4 aut
2451 0a Targeting MYC induces lipid droplet accumulation by upregulation of HILPDA in clear cell renal cell carcinoma
264 1b Proceedings of the National Academy of Sciences (PNAS),c 2024
520 a Metabolic reprogramming is critical during clear cell renal cell carcinoma (ccRCC) tumorigenesis, manifested by accumulation of lipid droplets (LDs), organelles that have emerged as new hallmarks of cancer. Yet, regulation of their biogenesis is still poorly understood. Here, we demonstrate that MYC inhibition in ccRCC cells lacking the von Hippel Lindau (VHL) gene leads to increased triglyceride content potentiating LD formation in a glutamine-dependent manner. Importantly, the concurrent inhibition of MYC signaling and glutamine metabolism prevented LD accumulation and reduced tumor burden in vivo. Furthermore, we identified the hypoxia-inducible lipid droplet-associated protein (HILPDA) as the key driver for induction of MYC-driven LD accumulation and demonstrated that conversely, proliferation, LD formation, and tumor growth are impaired upon its downregulation. Finally, analysis of ccRCC tissue as well as healthy renal control samples postulated HILPDA as a specific ccRCC biomarker. Together, these results provide an attractive approach for development of alternative therapeutic interventions for the treatment of this type of renal cancer.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650 7a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng
653 a clear cell renal cell carcinoma
653 a glutamine
653 a HILPDA
653 a lipid droplets
653 a MYC
7001 a Garde-Lapido, Elisau Karolinska Institutet,Karolinska Institute,Department of Microbiology, Tumor and Cell Biology, Biomedicum B7, Karolinska Institutet, Stockholm 17165, Sweden4 aut
7001 a Snaebjörnsson, Marteinn Thoru Division of Tumor Metabolism and Microenvironment, German Cancer Research Center, Heidelberg 69120, Germany4 aut
7001 a Schoch, Sarahu Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Njurcancergruppen,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Kidney cancer research group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund 22100, Sweden4 aut0 (Swepub:lu)sa4445sc
7001 a Stevens, Ireneu Karolinska Institutet,Karolinska Institute,Science for Life Laboratory, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 17165, Sweden4 aut
7001 a Ruiz-Pérez, María Victoriau Karolinska Institute,Department of Microbiology, Tumor and Cell Biology, Biomedicum B7, Karolinska Institutet, Stockholm 17165, Sweden4 aut
7001 a Dyrager, Christineu Uppsala universitet,Uppsala University,Organisk kemi4 aut0 (Swepub:uu)chrdy437
7001 a Pelechano, Vicentu Karolinska Institutet,Karolinska Institute,Science for Life Laboratory, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 17165, Sweden4 aut
7001 a Axelson, Håkanu Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Njurcancergruppen,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Kidney cancer research group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund 22100, Sweden4 aut0 (Swepub:lu)molm-hax
7001 a Schulze, Almutu Division of Tumor Metabolism and Microenvironment, German Cancer Research Center, Heidelberg 69120, Germany4 aut
7001 a Arsenian-Henriksson, Marieu Karolinska Institutet,Karolinska Institute,Department of Microbiology, Tumor and Cell Biology, Biomedicum B7, Karolinska Institutet, Stockholm 17165, Sweden4 aut
7102 a Karolinska Instituteb Department of Microbiology, Tumor and Cell Biology, Biomedicum B7, Karolinska Institutet, Stockholm 17165, Sweden4 org
7730 t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciences (PNAS)g 121:7, s. 2310479121-2310479121q 121:7<2310479121-2310479121x 1091-6490x 0027-8424
8564 u http://dx.doi.org/10.1073/pnas.2310479121x freey FULLTEXT
8564 u https://doi.org/10.1073/pnas.2310479121y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1840526/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://lup.lub.lu.se/record/649deff4-7b3a-422b-8dbe-c574de12ea9d
8564 8u https://doi.org/10.1073/pnas.2310479121
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-523864
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:238335255
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:155115811

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