Sökning: WFRF:(Pellis Tommaso) > Hypothermic versus ...
Fältnamn | Indikatorer | Metadata |
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000 | 07282naa a2200841 4500 | |
001 | oai:lup.lub.lu.se:7940623b-59a3-4ea4-b317-a2cbef468b01 | |
003 | SwePub | |
008 | 230508s2022 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:238319850 | |
024 | 7 | a https://lup.lub.lu.se/record/7940623b-59a3-4ea4-b317-a2cbef468b012 URI |
024 | 7 | a https://doi.org/10.1056/EVIDoa22001372 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2383198502 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Holgersson, Johanu Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Helsingborg Hospital4 aut0 (Swepub:lu)jo1784ho |
245 | 1 0 | a Hypothermic versus Normothermic Temperature Control after Cardiac Arrest |
264 | 1 | c 2022 |
520 | a BACKGROUNDThe evidence for temperature control for comatose survivors of cardiac arrest is inconclusive. Controversy exists as to whether the effects of hypothermia differ per the circumstances of the cardiac arrest or patient characteristics.METHODSAn individual patient data meta-analysis of the Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest (TTM) and Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trials was conducted. The intervention was hypothermia at 33°C and the comparator was normothermia. The primary outcome was all-cause mortality at 6 months. Secondary outcomes included poor functional outcome (modified Rankin scale score of 4 to 6) at 6 months. Predefined subgroups based on the design variables in the original trials were tested for interaction with the intervention as follows: age (older or younger than the median), sex (female or male), initial cardiac rhythm (shockable or nonshockable), time to return of spontaneous circulation (above or below the median), and circulatory shock on admission (presence or absence).RESULTSThe primary analyses included 2800 patients, with 1403 assigned to hypothermia and 1397 to normothermia. Death occurred for 691 of 1398 participants (49.4%) in the hypothermia group and 666 of 1391 participants (47.9%) in the normothermia group (relative risk with hypothermia, 1.03; 95% confidence interval [CI], 0.96 to 1.11; P=0.41). A poor functional outcome occurred for 733 of 1350 participants (54.3%) in the hypothermia group and 718 of 1330 participants (54.0%) in the normothermia group (relative risk with hypothermia, 1.01; 95% CI, 0.94 to 1.08; P=0.88). Outcomes were consistent in the predefined subgroups.CONCLUSIONSHypothermia at 33°C did not decrease 6-month mortality compared with normothermia after out-of-hospital cardiac arrest. (Funded by Vetenskapsrådet; ClinicalTrials.gov numbers NCT02908308 and NCT01020916.) | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Meyer, Martin Abild Stengaardu Copenhagen University Hospital4 aut |
700 | 1 | a Dankiewicz, Josefu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)med-jfd |
700 | 1 | a Lilja, Giselau Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-gal |
700 | 1 | a Ullén, Susannu Skåne University Hospital4 aut0 (Swepub:lu)su7040ul |
700 | 1 | a Hassager, Christianu Copenhagen University Hospital4 aut |
700 | 1 | a Cronberg, Tobiasu Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)efor-tcr |
700 | 1 | a Wise, Matt P.u University Hospital of Wales4 aut |
700 | 1 | a Bělohlávek, Janu Charles University in Prague4 aut |
700 | 1 | a Hovdenes, Janu Oslo university hospital4 aut |
700 | 1 | a Pelosi, Paolou Karolinska Institutet4 aut |
700 | 1 | a Erlinge, Davidu Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)kard-der |
700 | 1 | a Schrag, Claudiau Kantonsspital St Gallen4 aut |
700 | 1 | a Smid, Ondreju Charles University in Prague4 aut |
700 | 1 | a Brunetti, Ioleu University of Genoa4 aut |
700 | 1 | a Rylander, Christianu University of Gothenburg4 aut |
700 | 1 | a Young, Paul J.4 aut |
700 | 1 | a Saxena, Manoj4 aut |
700 | 1 | a Åneman, Anders4 aut |
700 | 1 | a Cariou, Alain4 aut |
700 | 1 | a Callaway, Clifton4 aut |
700 | 1 | a Eastwood, Glenn M.4 aut |
700 | 1 | a Haenggi, Matthias4 aut |
700 | 1 | a Joannidis, Michael4 aut |
700 | 1 | a Keeble, Thomas R.4 aut |
700 | 1 | a Kirkegaard, Hans4 aut |
700 | 1 | a Leithner, Christoph4 aut |
700 | 1 | a Levin, Helenau Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)ores-hal |
700 | 1 | a Nichol, Alistair D.4 aut |
700 | 1 | a Morgan, Matt P. G.4 aut |
700 | 1 | a Nordberg, Peru Karolinska Institutet4 aut0 (Swepub:lu)pe5482no |
700 | 1 | a Oddo, Mauro4 aut |
700 | 1 | a Storm, Christian4 aut |
700 | 1 | a Taccone, Fabio Silvio4 aut |
700 | 1 | a Thomas, Matthew4 aut |
700 | 1 | a Bro-Jeppesen, John4 aut |
700 | 1 | a Horn, Janneke4 aut |
700 | 1 | a Kjaergaard, Jesper4 aut |
700 | 1 | a Kuiper, Michael4 aut |
700 | 1 | a Pellis, Tommaso4 aut |
700 | 1 | a Stammet, Pascal4 aut |
700 | 1 | a Wanscher, Michael Jaeger4 aut |
700 | 1 | a Friberg, Hansu Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SWECRIT,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)efor-hfr |
700 | 1 | a Nielsen, Niklasu Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SEBRA Sepsis and Bacterial Resistance Alliance,Center for cardiac arrest,Lund University Research Groups,Helsingborg Hospital4 aut0 (Swepub:lu)med-nni |
700 | 1 | a Jakobsen, Janus Christian4 aut |
710 | 2 | a Kliniska Vetenskaper, Helsingborgb Sektion II4 org |
773 | 0 | t NEJM Evidenceg 1:11, s. 1-13q 1:11<1-13x 2766-5526 |
856 | 4 | u http://dx.doi.org/10.1056/EVIDoa2200137y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/7940623b-59a3-4ea4-b317-a2cbef468b01 |
856 | 4 8 | u https://doi.org/10.1056/EVIDoa2200137 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:238319850 |
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