Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression

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Fältnamn	Indikatorer	Metadata
000		06809naa a2201297 4500
001		oai:DiVA.org:uu-517874
003		SwePub
008		231214s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:237849304
009		oai:prod.swepub.kib.ki.se:155092148
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5178742 URI
024	7	a https://doi.org/10.1176/appi.ajp.202300532 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:2378493042 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1550921482 URI
040		a (SwePub)uud (SwePub)kid (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Guintivano, Jerry4 aut
245	1 0	a Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression
264	1	b American Psychiatric Association Publishing,c 2023
338		a print2 rdacarrier
520		a OBJECTIVE: Postpartum depression (PPD) is a common subtype of major depressive disorder (MDD) that is more heritable, yet is understudied in psychiatric genetics. The authors conducted meta-analyses of genome-wide association studies (GWASs) to investigate the genetic architecture of PPD.METHOD: Meta-analyses were conducted on 18 cohorts of European ancestry (17,339 PPD cases and 53,426 controls), one cohort of East Asian ancestry (975 cases and 3,780 controls), and one cohort of African ancestry (456 cases and 1,255 controls), totaling 18,770 PPD cases and 58,461 controls. Post-GWAS analyses included 1) single-nucleotide polymorphism (SNP)-based heritability ([Formula: see text]), 2) genetic correlations between PPD and other phenotypes, and 3) enrichment of the PPD GWAS findings in 27 human tissues and 265 cell types from the mouse central and peripheral nervous system.RESULTS: No SNP achieved genome-wide significance in the European or the trans-ancestry meta-analyses. The [Formula: see text] of PPD was 0.14 (SE=0.02). Significant genetic correlations were estimated for PPD with MDD, bipolar disorder, anxiety disorders, posttraumatic stress disorder, insomnia, age at menarche, and polycystic ovary syndrome. Cell-type enrichment analyses implicate inhibitory neurons in the thalamus and cholinergic neurons within septal nuclei of the hypothalamus, a pattern that differs from MDD.CONCLUSIONS: While more samples are needed to reach genome-wide levels of significance, the results presented confirm PPD as a polygenic and heritable phenotype. There is also evidence that despite a high correlation with MDD, PPD may have unique genetic components. Cell enrichment results suggest GABAergic neurons, which converge on a common mechanism with the only medication approved by the U.S. Food and Drug Administration for PPD (brexanolone).
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
653		a Genetics/Genomics
653		a Mood Disorders-Postpartum
700	1	a Byrne, Enda M4 aut
700	1	a Kiewa, Jacqueline4 aut
700	1	a Yao, Shuyangu Karolinska Institutet4 aut
700	1	a Bauer, Anna E4 aut
700	1	a Aberg, Karolina A4 aut
700	1	a Adams, Mark J4 aut
700	1	a Campbell, Archie4 aut
700	1	a Campbell, Megan L4 aut
700	1	a Choi, Karmel W4 aut
700	1	a Corfield, Elizabeth C4 aut
700	1	a Havdahl, Alexandra4 aut
700	1	a Hucks, Donald4 aut
700	1	a Koen, Nastassja4 aut
700	1	a Lu, Yiu Karolinska Institutet4 aut
700	1	a Mægbæk, Merete L4 aut
700	1	a Mullaert, Jimmy4 aut
700	1	a Peterson, Roseann E4 aut
700	1	a Raffield, Laura M4 aut
700	1	a Sallis, Hannah M4 aut
700	1	a Sealock, Julia M4 aut
700	1	a Walker, Alicia4 aut
700	1	a Watson, Hunna J4 aut
700	1	a Xiong, Ying4 aut
700	1	a Yang, Jessica M K4 aut
700	1	a Anney, Richard J L4 aut
700	1	a Gordon-Smith, Katherine4 aut
700	1	a Hubbard, Leon4 aut
700	1	a Jones, Lisa A4 aut
700	1	a Mihaescu, Raluca4 aut
700	1	a Nyegaard, Mette4 aut
700	1	a Pardiñas, Antonio F4 aut
700	1	a Perry, Amy4 aut
700	1	a Saquib, Nazmus4 aut
700	1	a Shadyab, Aladdin H4 aut
700	1	a Viktorin, Alexander4 aut
700	1	a Andreassen, Ole A4 aut
700	1	a Bigdeli, Tim B4 aut
700	1	a Davis, Lea K4 aut
700	1	a Dennis, Cindy-Lee4 aut
700	1	a Di Florio, Arianna4 aut
700	1	a Dubertret, Caroline4 aut
700	1	a Feng, Yen-Chen A4 aut
700	1	a Frey, Benicio N4 aut
700	1	a Grigoriadis, Sophie4 aut
700	1	a Gloaguen, Emilie4 aut
700	1	a Jones, Ian4 aut
700	1	a Kennedy, James L4 aut
700	1	a Krohn, Holly4 aut
700	1	a Kunovac Kallak, Theodora,d 1985-u Uppsala universitet,Reproduktiv hälsa4 aut0 (Swepub:uu)theka349
700	1	a Li, Yun4 aut
700	1	a Martin, Nicholas G4 aut
700	1	a McIntosh, Andrew M4 aut
700	1	a Milgrom, Jeannette4 aut
700	1	a Munk-Olsen, Trine4 aut
700	1	a Oberlander, Tim4 aut
700	1	a Olsen, Catherine M4 aut
700	1	a Ramoz, Nicolas4 aut
700	1	a Reichborn-Kjennerud, Ted4 aut
700	1	a Robertson Blackmore, Emma4 aut
700	1	a Rubinow, David4 aut
700	1	a Skalkidou, Alkistis,d 1977-u Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning4 aut0 (Swepub:uu)alksk607
700	1	a Smoller, Jordan W4 aut
700	1	a Stein, Dan J4 aut
700	1	a Stowe, Zachary N4 aut
700	1	a Taylor, Valerie4 aut
700	1	a Tebeka, Sarah4 aut
700	1	a Tesli, Martin4 aut
700	1	a Van Lieshout, Ryan J4 aut
700	1	a van den Oord, Edwin J C G4 aut
700	1	a Vigod, Simone N4 aut
700	1	a Werge, Thomas4 aut
700	1	a Westlye, Lars T4 aut
700	1	a Whiteman, David C4 aut
700	1	a Zar, Heather J4 aut
700	1	a Wray, Naomi4 aut
700	1	a Meltzer-Brody, Samantha4 aut
700	1	a Sullivan, Patrick4 aut
710	2	a Karolinska Institutetb Reproduktiv hälsa4 org
773	0	t American Journal of Psychiatryd : American Psychiatric Association Publishingg 180:12, s. 884-895q 180:12<884-895x 0002-953Xx 1535-7228
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-517874
856	4 8	u https://doi.org/10.1176/appi.ajp.20230053
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:237849304
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:155092148

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Av författaren/redakt...: Guintivano, Jerr ...; Byrne, Enda M; Kiewa, Jacquelin ...; Yao, Shuyang; Bauer, Anna E; Aberg, Karolina ...; visa fler...; Adams, Mark J; Campbell, Archie; Campbell, Megan ...; Choi, Karmel W; Corfield, Elizab ...; Havdahl, Alexand ...; Hucks, Donald; Koen, Nastassja; Lu, Yi; Mægbæk, Merete L; Mullaert, Jimmy; Peterson, Rosean ...; Raffield, Laura ...; Sallis, Hannah M; Sealock, Julia M; Walker, Alicia; Watson, Hunna J; Xiong, Ying; Yang, Jessica M ...; Anney, Richard J ...; Gordon-Smith, Ka ...; Hubbard, Leon; Jones, Lisa A; Mihaescu, Raluca; Nyegaard, Mette; Pardiñas, Antoni ...; Perry, Amy; Saquib, Nazmus; Shadyab, Aladdin ...; Viktorin, Alexan ...; Andreassen, Ole ...; Bigdeli, Tim B; Davis, Lea K; Dennis, Cindy-Le ...; Di Florio, Arian ...; Dubertret, Carol ...; Feng, Yen-Chen A; Frey, Benicio N; Grigoriadis, Sop ...; Gloaguen, Emilie; Jones, Ian; Kennedy, James L; Krohn, Holly; Kunovac Kallak, ...; Li, Yun; Martin, Nicholas ...; McIntosh, Andrew ...; Milgrom, Jeannet ...; Munk-Olsen, Trin ...; Oberlander, Tim; Olsen, Catherine ...; Ramoz, Nicolas; Reichborn-Kjenne ...; Robertson Blackm ...; Rubinow, David; Skalkidou, Alkis ...; Smoller, Jordan ...; Stein, Dan J; Stowe, Zachary N; Taylor, Valerie; Tebeka, Sarah; Tesli, Martin; Van Lieshout, Ry ...; van den Oord, Ed ...; Vigod, Simone N; Werge, Thomas; Westlye, Lars T; Whiteman, David ...; Zar, Heather J; Wray, Naomi; Meltzer-Brody, S ...; Sullivan, Patric ...; visa färre...

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