WFRF:(Rose Lynda M.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 15411naa a2203769 4500 | |
| 001 | oai:DiVA.org:umu-161740 | |
| 003 | SwePub | |
| 008 | 190726s2019 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:214a185e-d344-42e1-8185-4c5840429109 | |
| 009 | oai:prod.swepub.kib.ki.se:141294981 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1617402 URI |
| 024 | 7 | a https://doi.org/10.1093/aje/kwz0052 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/214a185e-d344-42e1-8185-4c58404291092 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1412949812 URI |
| 040 | a (SwePub)umud (SwePub)lud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a de Vries, Paul S.u University of Texas4 aut |
| 245 | 1 0 | a Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions |
| 264 | c 2019-01-29 | |
| 264 | 1 | b Oxford University Press,c 2019 |
| 338 | a print2 rdacarrier | |
| 520 | a A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394,584 individuals from 5 ancestry groups. Analyses covered the period July 2014-November 2017. Genetic main effects and interaction effects were jointly assessed by means of a 2-degrees-of-freedom (df) test, and a 1-df test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P < 1 x 10(-6)) with lipid levels in stage 1 and were evaluated in stage 2, followed by combined analyses of stage 1 and stage 2. In the combined analysis of stages 1 and 2, a total of 147 independent loci were associated with lipid levels at P < 5 x 10(-8) using 2-df tests, of which 18 were novel. No genome-wide-significant associations were found testing the interaction effect alone. The novel loci included several genes (proprotein convertase subtilisin/kexin type 5 (PCSK5), vascular endothelial growth factor B (VEGFB), and apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1) complementation factor (A1CF)) that have a putative role in lipid metabolism on the basis of existing evidence from cellular and experimental models. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
| 653 | a alcohol consumption | |
| 653 | a cholesterol | |
| 653 | a gene-environment interactions | |
| 653 | a gene-lifestyle interactions | |
| 653 | a genome-wide association studies | |
| 653 | a lipids | |
| 653 | a triglycerides | |
| 653 | a alcohol consumption | |
| 653 | a cholesterol | |
| 653 | a gene-environment interactions | |
| 653 | a gene-lifestyle interactions | |
| 653 | a genome-wide association studies | |
| 653 | a lipids | |
| 653 | a triglycerides | |
| 700 | 1 | a Brown, Michael R.4 aut |
| 700 | 1 | a Bentley, Amy R.4 aut |
| 700 | 1 | a Sung, Yun J.4 aut |
| 700 | 1 | a Winkler, Thomas W.4 aut |
| 700 | 1 | a Ntalla, Ioanna4 aut |
| 700 | 1 | a Schwander, Karen4 aut |
| 700 | 1 | a Kraja, Aldi T.4 aut |
| 700 | 1 | a Guo, Xiuqing4 aut |
| 700 | 1 | a Franceschini, Nora4 aut |
| 700 | 1 | a Cheng, Ching-Yu4 aut |
| 700 | 1 | a Sim, Xueling4 aut |
| 700 | 1 | a Vojinovic, Dina4 aut |
| 700 | 1 | a Huffman, Jennifer E.4 aut |
| 700 | 1 | a Musani, Solomon K.4 aut |
| 700 | 1 | a Li, Changwei4 aut |
| 700 | 1 | a Feitosa, Mary F.4 aut |
| 700 | 1 | a Richard, Melissa A.4 aut |
| 700 | 1 | a Noordam, Raymond4 aut |
| 700 | 1 | a Aschard, Hugues4 aut |
| 700 | 1 | a Bartz, Traci M.4 aut |
| 700 | 1 | a Bielak, Lawrence F.4 aut |
| 700 | 1 | a Deng, Xuan4 aut |
| 700 | 1 | a Dorajoo, Rajkumar4 aut |
| 700 | 1 | a Lohman, Kurt K.4 aut |
| 700 | 1 | a Manning, Alisa K.4 aut |
| 700 | 1 | a Rankinen, Tuomo4 aut |
| 700 | 1 | a Smith, Albert V.4 aut |
| 700 | 1 | a Tajuddin, Salman M.4 aut |
| 700 | 1 | a Evangelou, Evangelosu Karolinska Institutet4 aut |
| 700 | 1 | a Graff, Mariaelisa4 aut |
| 700 | 1 | a Alver, Maris4 aut |
| 700 | 1 | a Boissel, Mathilde4 aut |
| 700 | 1 | a Chai, Jin Fang4 aut |
| 700 | 1 | a Chen, Xuu Karolinska Institutet4 aut |
| 700 | 1 | a Divers, Jasmin4 aut |
| 700 | 1 | a Gandin, Ilaria4 aut |
| 700 | 1 | a Gao, Chuan4 aut |
| 700 | 1 | a Goel, Anuj4 aut |
| 700 | 1 | a Hagemeijer, Yanick4 aut |
| 700 | 1 | a Harris, Sarah E.4 aut |
| 700 | 1 | a Hartwig, Fernando P.4 aut |
| 700 | 1 | a He, Meian4 aut |
| 700 | 1 | a Horimoto, Andrea R. V. R.4 aut |
| 700 | 1 | a Hsu, Fang-Chi4 aut |
| 700 | 1 | a Jackson, Anne U.4 aut |
| 700 | 1 | a Kasturiratne, Anuradhani4 aut |
| 700 | 1 | a Komulainen, Pirjo4 aut |
| 700 | 1 | a Kuehnel, Brigitte4 aut |
| 700 | 1 | a Laguzzi, Federicau Karolinska Institutet4 aut |
| 700 | 1 | a Lee, Joseph H.4 aut |
| 700 | 1 | a Luan, Jian'an4 aut |
| 700 | 1 | a Lyytikainen, Leo-Pekka4 aut |
| 700 | 1 | a Matoba, Nana4 aut |
| 700 | 1 | a Nolte, Ilja M.4 aut |
| 700 | 1 | a Pietzner, Maik4 aut |
| 700 | 1 | a Riaz, Muhammad4 aut |
| 700 | 1 | a Said, M. Abdullah4 aut |
| 700 | 1 | a Scott, Robert A.4 aut |
| 700 | 1 | a Sofer, Tamar4 aut |
| 700 | 1 | a Stancakova, Alena4 aut |
| 700 | 1 | a Takeuchi, Fumihiko4 aut |
| 700 | 1 | a Tayo, Bamidele O.4 aut |
| 700 | 1 | a van der Most, Peter J.4 aut |
| 700 | 1 | a V. Varga, Tiboru Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-tv_ |
| 700 | 1 | a Wang, Yajuan4 aut |
| 700 | 1 | a Ware, Erin B.4 aut |
| 700 | 1 | a Wen, Wanqing4 aut |
| 700 | 1 | a Yanek, Lisa R.4 aut |
| 700 | 1 | a Zhang, Weihua4 aut |
| 700 | 1 | a Zhao, Jing Hua4 aut |
| 700 | 1 | a Afaq, Saima4 aut |
| 700 | 1 | a Amin, Najaf4 aut |
| 700 | 1 | a Amini, Marzyeh4 aut |
| 700 | 1 | a Arking, Dan E.4 aut |
| 700 | 1 | a Aung, Tin4 aut |
| 700 | 1 | a Ballantyne, Christie4 aut |
| 700 | 1 | a Boerwinkle, Eric4 aut |
| 700 | 1 | a Broeckel, Ulrich4 aut |
| 700 | 1 | a Campbell, Archie4 aut |
| 700 | 1 | a Canouil, Mickael4 aut |
| 700 | 1 | a Charumathi, Sabanayagam4 aut |
| 700 | 1 | a Chen, Yii-Der Ida4 aut |
| 700 | 1 | a Connell, John M.4 aut |
| 700 | 1 | a de Faire, Ulfu Karolinska Institutet4 aut |
| 700 | 1 | a de las Fuentes, Lisa4 aut |
| 700 | 1 | a de Mutsert, Renee4 aut |
| 700 | 1 | a de Silva, H. Janaka4 aut |
| 700 | 1 | a Ding, Jingzhong4 aut |
| 700 | 1 | a Dominiczak, Anna F.4 aut |
| 700 | 1 | a Duan, Qing4 aut |
| 700 | 1 | a Eaton, Charles B.4 aut |
| 700 | 1 | a Eppinga, Ruben N.4 aut |
| 700 | 1 | a Faul, Jessica D.4 aut |
| 700 | 1 | a Fisher, Virginia4 aut |
| 700 | 1 | a Forrester, Terrence4 aut |
| 700 | 1 | a Franco, Oscar H.4 aut |
| 700 | 1 | a Friedlander, Yechiel4 aut |
| 700 | 1 | a Ghanbari, Mohsen4 aut |
| 700 | 1 | a Giulianini, Franco4 aut |
| 700 | 1 | a Grabe, Hans J.4 aut |
| 700 | 1 | a Grove, Megan L.4 aut |
| 700 | 1 | a Gu, C. Charles4 aut |
| 700 | 1 | a Harris, Tamara B.4 aut |
| 700 | 1 | a Heikkinen, Sami4 aut |
| 700 | 1 | a Heng, Chew-Kiat4 aut |
| 700 | 1 | a Hirata, Makoto4 aut |
| 700 | 1 | a Hixson, James E.4 aut |
| 700 | 1 | a Howard, Barbara V.4 aut |
| 700 | 1 | a Ikram, M. Arfan4 aut |
| 700 | 1 | a Jacobs, David R., Jr.4 aut |
| 700 | 1 | a Johnson, Craig4 aut |
| 700 | 1 | a Jonas, Jost Bruno4 aut |
| 700 | 1 | a Kammerer, Candace M.4 aut |
| 700 | 1 | a Katsuya, Tomohiro4 aut |
| 700 | 1 | a Khor, Chiea Chuen4 aut |
| 700 | 1 | a Kilpelainen, Tuomas O.4 aut |
| 700 | 1 | a Koh, Woon-Puay4 aut |
| 700 | 1 | a Koistinen, Heikki A.4 aut |
| 700 | 1 | a Kolcic, Ivana4 aut |
| 700 | 1 | a Kooperberg, Charles4 aut |
| 700 | 1 | a Krieger, Jose E.4 aut |
| 700 | 1 | a Kritchevsky, Steve B.4 aut |
| 700 | 1 | a Kubo, Michiaki4 aut |
| 700 | 1 | a Kuusisto, Johanna4 aut |
| 700 | 1 | a Lakka, Timo A.4 aut |
| 700 | 1 | a Langefeld, Carl D.4 aut |
| 700 | 1 | a Langenberg, Claudia4 aut |
| 700 | 1 | a Launer, Lenore J.4 aut |
| 700 | 1 | a Lehne, Benjamin4 aut |
| 700 | 1 | a Lemaitre, Rozenn N.4 aut |
| 700 | 1 | a Li, Yize4 aut |
| 700 | 1 | a Liang, Jingjing4 aut |
| 700 | 1 | a Liu, Jianjun4 aut |
| 700 | 1 | a Liu, Kiang4 aut |
| 700 | 1 | a Loh, Marie4 aut |
| 700 | 1 | a Louie, Tin4 aut |
| 700 | 1 | a Magi, Reedik4 aut |
| 700 | 1 | a Manichaikul, Ani W.4 aut |
| 700 | 1 | a McKenzie, Colin A.4 aut |
| 700 | 1 | a Meitinger, Thomas4 aut |
| 700 | 1 | a Metspalu, Andres4 aut |
| 700 | 1 | a Milaneschi, Yuri4 aut |
| 700 | 1 | a Milani, Lili4 aut |
| 700 | 1 | a Mohlke, Karen L.u Karolinska Institutet4 aut |
| 700 | 1 | a Mosley, Thomas H., Jr.4 aut |
| 700 | 1 | a Mukamal, Kenneth J.4 aut |
| 700 | 1 | a Nalls, Mike A.4 aut |
| 700 | 1 | a Nauck, Matthias4 aut |
| 700 | 1 | a Nelson, Christopher P.4 aut |
| 700 | 1 | a Sotoodehnia, Nona4 aut |
| 700 | 1 | a O'Connell, Jeff R.4 aut |
| 700 | 1 | a Palmer, Nicholette D.4 aut |
| 700 | 1 | a Pazoki, Raha4 aut |
| 700 | 1 | a Pedersen, Nancy L.u Karolinska Institutet4 aut |
| 700 | 1 | a Peters, Annette4 aut |
| 700 | 1 | a Peyser, Patricia A.4 aut |
| 700 | 1 | a Polasek, Ozren4 aut |
| 700 | 1 | a Poulter, Neil4 aut |
| 700 | 1 | a Raffel, Leslie J.4 aut |
| 700 | 1 | a Raitakari, Olli T.4 aut |
| 700 | 1 | a Reiner, Alex P.4 aut |
| 700 | 1 | a Rice, Treva K.4 aut |
| 700 | 1 | a Rich, Stephen S.4 aut |
| 700 | 1 | a Robino, Antonietta4 aut |
| 700 | 1 | a Robinson, Jennifer G.4 aut |
| 700 | 1 | a Rose, Lynda M.4 aut |
| 700 | 1 | a Rudan, Igor4 aut |
| 700 | 1 | a Schmidt, Carsten O.4 aut |
| 700 | 1 | a Schreiner, Pamela J.4 aut |
| 700 | 1 | a Scott, William R.4 aut |
| 700 | 1 | a Sever, Peter4 aut |
| 700 | 1 | a Shi, Yuan4 aut |
| 700 | 1 | a Sidney, Stephen4 aut |
| 700 | 1 | a Sims, Mario4 aut |
| 700 | 1 | a Smith, Blair H.4 aut |
| 700 | 1 | a Smith, Jennifer A.4 aut |
| 700 | 1 | a Snieder, Harold4 aut |
| 700 | 1 | a Starr, John M.4 aut |
| 700 | 1 | a Strauch, Konstantin4 aut |
| 700 | 1 | a Tan, Nicholas4 aut |
| 700 | 1 | a Taylor, Kent D.4 aut |
| 700 | 1 | a Teo, Yik Ying4 aut |
| 700 | 1 | a Tham, Yih Chung4 aut |
| 700 | 1 | a Uitterlinden, Andre G.4 aut |
| 700 | 1 | a van Heemst, Diana4 aut |
| 700 | 1 | a Vuckovic, Dragana4 aut |
| 700 | 1 | a Waldenberger, Melanie4 aut |
| 700 | 1 | a Wang, Lihua4 aut |
| 700 | 1 | a Wang, Yujie4 aut |
| 700 | 1 | a Wang, Zhe4 aut |
| 700 | 1 | a Wei, Wen Bin4 aut |
| 700 | 1 | a Williams, Christine4 aut |
| 700 | 1 | a Wilson, Gregory, Sr.4 aut |
| 700 | 1 | a Wojczynski, Mary K.4 aut |
| 700 | 1 | a Yao, Jie4 aut |
| 700 | 1 | a Yu, Bing4 aut |
| 700 | 1 | a Yu, Caizheng4 aut |
| 700 | 1 | a Yuan, Jian-Min4 aut |
| 700 | 1 | a Zhao, Wei4 aut |
| 700 | 1 | a Zonderman, Alan B.4 aut |
| 700 | 1 | a Becker, Diane M.4 aut |
| 700 | 1 | a Boehnke, Michael4 aut |
| 700 | 1 | a Bowden, Donald W.4 aut |
| 700 | 1 | a Chambers, John C.4 aut |
| 700 | 1 | a Deary, Ian J.4 aut |
| 700 | 1 | a Esko, Tonu4 aut |
| 700 | 1 | a Farrall, Martin4 aut |
| 700 | 1 | a Franks, Paul W.u Umeå University,Lund University,Lunds universitet,Umeå universitet,Avdelningen för medicin,Department of Nutrition, T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Medical Sciences Division, University of Oxford, Oxford, United Kingdom,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf |
| 700 | 1 | a Freedman, Barry I.4 aut |
| 700 | 1 | a Froguel, Philippe4 aut |
| 700 | 1 | a Gasparini, Paolo4 aut |
| 700 | 1 | a Gieger, Christian4 aut |
| 700 | 1 | a Horta, Bernardo L.4 aut |
| 700 | 1 | a Kamatani, Yoichiro4 aut |
| 700 | 1 | a Kato, Norihiro4 aut |
| 700 | 1 | a Kooner, Jaspal S.4 aut |
| 700 | 1 | a Laakso, Markku4 aut |
| 700 | 1 | a Leander, Karin4 aut |
| 700 | 1 | a Lehtimaki, Terho4 aut |
| 700 | 1 | a Magnusson, Patrik K. E.4 aut |
| 700 | 1 | a Penninx, Brenda4 aut |
| 700 | 1 | a Pereira, Alexandre C.4 aut |
| 700 | 1 | a Rauramaa, Rainer4 aut |
| 700 | 1 | a Samani, Nilesh J.4 aut |
| 700 | 1 | a Scott, James4 aut |
| 700 | 1 | a Shu, Xiao-Ou4 aut |
| 700 | 1 | a van der Harst, Pim4 aut |
| 700 | 1 | a Wagenknecht, Lynne E.4 aut |
| 700 | 1 | a Wang, Ya Xing4 aut |
| 700 | 1 | a Wareham, Nicholas J.4 aut |
| 700 | 1 | a Watkins, Hugh4 aut |
| 700 | 1 | a Weir, David R.4 aut |
| 700 | 1 | a Wickremasinghe, Ananda R.4 aut |
| 700 | 1 | a Zheng, Wei4 aut |
| 700 | 1 | a Elliott, Paul4 aut |
| 700 | 1 | a North, Kari E.4 aut |
| 700 | 1 | a Bouchard, Claude4 aut |
| 700 | 1 | a Evans, Michele K.4 aut |
| 700 | 1 | a Gudnason, Vilmundur4 aut |
| 700 | 1 | a Liu, Ching-Ti4 aut |
| 700 | 1 | a Liu, Yongmei4 aut |
| 700 | 1 | a Psaty, Bruce M.4 aut |
| 700 | 1 | a Ridker, Paul M.4 aut |
| 700 | 1 | a van Dam, Rob M.4 aut |
| 700 | 1 | a Kardia, Sharon L. R.4 aut |
| 700 | 1 | a Zhu, Xiaofeng4 aut |
| 700 | 1 | a Rotimi, Charles N.4 aut |
| 700 | 1 | a Mook-Kanamori, Dennis O.4 aut |
| 700 | 1 | a Fornage, Myriam4 aut |
| 700 | 1 | a Kelly, Tanika N.4 aut |
| 700 | 1 | a Fox, Ervin R.4 aut |
| 700 | 1 | a Hayward, Caroline4 aut |
| 700 | 1 | a van Duijn, Cornelia M.4 aut |
| 700 | 1 | a Tai, E. Shyong4 aut |
| 700 | 1 | a Wong, Tien Yin4 aut |
| 700 | 1 | a Liu, Jingmin4 aut |
| 700 | 1 | a Rotter, Jerome I.4 aut |
| 700 | 1 | a Gauderman, W. James4 aut |
| 700 | 1 | a Province, Michael A.4 aut |
| 700 | 1 | a Munroe, Patricia B.4 aut |
| 700 | 1 | a Rice, Kenneth4 aut |
| 700 | 1 | a Chasman, Daniel I.4 aut |
| 700 | 1 | a Cupples, L. Adrienne4 aut |
| 700 | 1 | a Rao, Dabeeru C.4 aut |
| 700 | 1 | a Morrison, Alanna C.u University of Texas4 aut |
| 710 | 2 | a Karolinska Institutetb University of Texas4 org |
| 710 | 2 | a et al. |
| 773 | 0 | t American Journal of Epidemiologyd : Oxford University Pressg 188:6, s. 1033-1054q 188:6<1033-1054x 0002-9262x 1476-6256 |
| 856 | 4 | u https://academic.oup.com/aje/article-pdf/188/6/1033/32921017/kwz005.pdf |
| 856 | 4 | u http://dx.doi.org/10.1093/aje/kwz005y FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161740 |
| 856 | 4 8 | u https://doi.org/10.1093/aje/kwz005 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/214a185e-d344-42e1-8185-4c5840429109 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141294981 |
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