A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

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Fältnamn	Indikatorer	Metadata
000		05091naa a2200961 4500
001		oai:lup.lub.lu.se:727d67c9-3721-44c6-9c2b-d55423cf5a22
003		SwePub
008		160401s2008 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/11828822 URI
024	7	a https://doi.org/10.1038/nature068462 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Thorgeirsson, Thorgeir E4 aut
245	1 0	a A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
264	1	b Springer Science and Business Media LLC,c 2008
520		a Smoking is a leading cause of preventable death, causing about 5 million premature deaths worldwide each year(1,2). Evidence for genetic influence on smoking behaviour and nicotine dependence (ND)(3-8) has prompted a search for susceptibility genes. Furthermore, assessing the impact of sequence variants on smoking-related diseases is important to public health(9,10). Smoking is the major risk factor for lung cancer (LC)(11-14) and is one of the main risk factors for peripheral arterial disease (PAD)(15-17). Here we identify a common variant in the nicotinic acetylcholine receptor gene cluster on chromosome 15q24 with an effect on smoking quantity, ND and the risk of two smoking- related diseases in populations of European descent. The variant has an effect on the number of cigarettes smoked per day in our sample of smokers. The same variant was associated with ND in a previous genomewide association study that used low- quantity smokers as controls(18,19), and with a similar approach we observe a highly significant association with ND. A comparison of cases of LC and PAD with population controls each showed that the variant confers risk of LC and PAD. The findings provide a case study of a gene - environment interaction(20), highlighting the role of nicotine addiction in the pathology of other serious diseases.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
700	1	a Geller, Frank4 aut
700	1	a Sulem, Patrick4 aut
700	1	a Rafnar, Thorunn4 aut
700	1	a Wiste, Anna4 aut
700	1	a Magnusson, Kristinn P4 aut
700	1	a Manolescu, Andrei4 aut
700	1	a Thorleifsson, Gudmar4 aut
700	1	a Stefansson, Hreinn4 aut
700	1	a Ingason, Andres4 aut
700	1	a Stacey, Simon N4 aut
700	1	a Bergthorsson, Jon T4 aut
700	1	a Thorlacius, Steinunn4 aut
700	1	a Gudmundsson, Julius4 aut
700	1	a Jonsson, Thorlakur4 aut
700	1	a Jakobsdottir, Margret4 aut
700	1	a Saemundsdottir, Jona4 aut
700	1	a Olafsdottir, Olof4 aut
700	1	a Gudmundsson, Larus J4 aut
700	1	a Bjornsdottir, Gyda4 aut
700	1	a Kristjansson, Kristleifur4 aut
700	1	a Skuladottir, Halla4 aut
700	1	a Isaksson, Helgi J4 aut
700	1	a Gudbjartsson, Tomas4 aut
700	1	a Jones, Gregory T4 aut
700	1	a Mueller, Thomas4 aut
700	1	a Gottsäter, Andersu Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups4 aut0 (Swepub:lu)medf-ago
700	1	a Flex, Andrea4 aut
700	1	a Aben, Katja K H4 aut
700	1	a de Vegt, Femmie4 aut
700	1	a Mulders, Peter F A4 aut
700	1	a Isla, Dolores4 aut
700	1	a Vidal, Maria J4 aut
700	1	a Asin, Laura4 aut
700	1	a Saez, Berta4 aut
700	1	a Murillo, Laura4 aut
700	1	a Blondal, Thorsteinn4 aut
700	1	a Kolbeinsson, Halldor4 aut
700	1	a Stefansson, Jon G4 aut
700	1	a Hansdottir, Ingunn4 aut
700	1	a Runarsdottir, Valgerdur4 aut
700	1	a Pola, Roberto4 aut
700	1	a Lindblad, Bengt4 aut
700	1	a van Rij, Andre M4 aut
700	1	a Dieplinger, Benjamin4 aut
700	1	a Haltmayer, Meinhard4 aut
700	1	a Mayordomo, Jose I4 aut
700	1	a Kiemeney, Lambertus A4 aut
700	1	a Matthiasson, Stefan E4 aut
700	1	a Oskarsson, Hogni4 aut
700	1	a Tyrfingsson, Thorarinn4 aut
700	1	a Gudbjartsson, Daniel F4 aut
700	1	a Gulcher, Jeffrey R4 aut
700	1	a Jonsson, Steinn4 aut
700	1	a Thorsteinsdottir, Unnur4 aut
700	1	a Kong, Augustine4 aut
700	1	a Stefansson, Kari4 aut
710	2	a Vaskulära sjukdomar - kliniska studierb Forskargrupper vid Lunds universitet4 org
773	0	t Natured : Springer Science and Business Media LLCg 452:7187, s. 9-638q 452:7187<9-638x 0028-0836x 1476-4687
856	4	u http://dx.doi.org/10.1038/nature06846y FULLTEXT
856	4	u https://europepmc.org/articles/pmc4539558?pdf=render
856	4 8	u https://lup.lub.lu.se/record/1182882
856	4 8	u https://doi.org/10.1038/nature06846

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Av författaren/redakt...: Thorgeirsson, Th ...; Geller, Frank; Sulem, Patrick; Rafnar, Thorunn; Wiste, Anna; Magnusson, Krist ...; visa fler...; Manolescu, Andre ...; Thorleifsson, Gu ...; Stefansson, Hrei ...; Ingason, Andres; Stacey, Simon N; Bergthorsson, Jo ...; Thorlacius, Stei ...; Gudmundsson, Jul ...; Jonsson, Thorlak ...; Jakobsdottir, Ma ...; Saemundsdottir, ...; Olafsdottir, Olo ...; Gudmundsson, Lar ...; Bjornsdottir, Gy ...; Kristjansson, Kr ...; Skuladottir, Hal ...; Isaksson, Helgi ...; Gudbjartsson, To ...; Jones, Gregory T; Mueller, Thomas; Gottsäter, Ander ...; Flex, Andrea; Aben, Katja K H; de Vegt, Femmie; Mulders, Peter F ...; Isla, Dolores; Vidal, Maria J; Asin, Laura; Saez, Berta; Murillo, Laura; Blondal, Thorste ...; Kolbeinsson, Hal ...; Stefansson, Jon ...; Hansdottir, Ingu ...; Runarsdottir, Va ...; Pola, Roberto; Lindblad, Bengt; van Rij, Andre M; Dieplinger, Benj ...; Haltmayer, Meinh ...; Mayordomo, Jose ...; Kiemeney, Lamber ...; Matthiasson, Ste ...; Oskarsson, Hogni; Tyrfingsson, Tho ...; Gudbjartsson, Da ...; Gulcher, Jeffrey ...; Jonsson, Steinn; Thorsteinsdottir ...; Kong, Augustine; Stefansson, Kari; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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Av lärosätet: Lunds universitet

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