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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04728naa a2200421 4500 | |
| 001 | oai:lup.lub.lu.se:0d7a14cf-4425-46a0-9f73-3b0da0481807 | |
| 003 | SwePub | |
| 008 | 220323s2005 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/0d7a14cf-4425-46a0-9f73-3b0da04818072 URI |
| 024 | 7 | a https://doi.org/10.1111/j.1538-7836.2004.01010.x2 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Vaziri-Sani, F.u Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Celiac Disease and Diabetes Unit,Lund University Research Groups4 aut0 (Swepub:lu)fa3255va |
| 245 | 1 0 | a Factor H binds to washed human platelets |
| 264 | 1 | b Elsevier BV,c 2005 |
| 520 | a Background: Factor H regulates the alternative pathway of complement. The protein has three heparin-binding sites, is synthesized primarily in the liver and copurifies from platelets with thrombospondin-1. Factor H mutations at the C-terminus are associated with atypical hemolytic uremic syndrome, a condition in which platelets are consumed. Objectives The aim of this study was to investigate if factor H interacts with platelets. Methods: Binding of factor H, recombinant C- or N-terminus constructs and a C-terminus mutant to washed (plasma and complement-free) platelets was analyzed by flow cytometry. Binding of factor H and constructs to thrombospondin-1 was measured by surface plasmon resonance. Results: Factor H bound to platelets in a dose-dependent manner. The major binding site was localized to the C-terminus. The interaction was partially blocked by heparin. Inhibition with anti-GPIIb/IIIa, or with fibrinogen, suggested that the platelet GPIIb/IIIa receptor is involved in factor H binding. Factor H binds to thrombospondin-1. Addition of thrombospondin-1 increased factor H binding to platelets. Factor H mutated at the C-terminus also bound to platelets, albeit to a significantly lesser degree. Conclusions: This study reports a novel property of factor H, i.e. binding to platelets, either directly via the GPIIb/IIIa receptor or indirectly via thrombospondin-1, in the absence of complement. Binding to platelets was mostly mediated by the C-terminal region of factor H and factor H mutated at the C-terminus exhibited reduced binding. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 653 | a Complement | |
| 653 | a Factor H | |
| 653 | a Hemolytic uremic syndrome | |
| 653 | a Platelets | |
| 700 | 1 | a Hellwage, J.u Leibniz Institute for Natural Product Research and Infection Biology4 aut |
| 700 | 1 | a Zipfel, P. F.u Leibniz Institute for Natural Product Research and Infection Biology4 aut |
| 700 | 1 | a Sjöholm, A. G.u Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)mmb-asj |
| 700 | 1 | a Iancu, R.u Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine4 aut0 (Swepub:lu)mphy-ria |
| 700 | 1 | a Karpman, D.u Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pediatrisk nefrologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Pediatric Nephrology,Lund University Research Groups4 aut0 (Swepub:lu)pedi-dka |
| 710 | 2 | a Pediatrik, Lundb Sektion V4 org |
| 773 | 0 | t Journal of Thrombosis and Haemostasisd : Elsevier BVg 3:1, s. 154-162q 3:1<154-162x 1538-7933x 1538-7836 |
| 856 | 4 | u http://dx.doi.org/10.1111/j.1538-7836.2004.01010.xx freey FULLTEXT |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1538-7836.2004.01010.x |
| 856 | 4 8 | u https://lup.lub.lu.se/record/0d7a14cf-4425-46a0-9f73-3b0da0481807 |
| 856 | 4 8 | u https://doi.org/10.1111/j.1538-7836.2004.01010.x |
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