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Spatial Dynamics of...
Spatial Dynamics of the Developing Human Heart
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- Lázár, Enikő (författare)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,Department of Cell and Molecular Biology, Karolinska Institute, 17165 Solna, Sweden
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- Mauron, Raphaël (författare)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Andrusivova, Zaneta (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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- Foyer, Julia (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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- Larsson, Ludvig (författare)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Shakari, Nick (författare)
- Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, 171659 Solna, Sweden
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- Marco Salas, Sergio (författare)
- Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, 171659 Solna, Sweden
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- Sariyar, Sanem (författare)
- KTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab
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- Hansen, Jan Niklas (författare)
- KTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab,Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
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- Vicari, Marco (författare)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Czarnewski, Paulo, 1991- (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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- Braun, Emelie (författare)
- Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17165 Solna, Sweden
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- Li, Xiaofei (författare)
- Division of Neurodegeneration, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, 17165 Solna, Sweden
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- Bergmann, Olaf (författare)
- Department of Cell and Molecular Biology, Karolinska Institute, 17165 Solna, Sweden; Department of Pharmacology and Toxicology, University Medical Center Goettingen, 37075 Goettingen, Germany; Center for Regenerative Therapies Dresden, TU Dresden, 01307 Dresden, Germany
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- Sylvén, Christer (författare)
- Department of Medicine, Karolinska Institute, 14157 Huddinge, Sweden
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- Käller Lundberg, Emma (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Pathology, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, San Francisco, CA 94158, USA
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- Linnarsson, Sten (författare)
- Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17165 Solna, Sweden
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- Nilsson, Mats (författare)
- Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, 171659 Solna, Sweden
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- Sundström, Erik (författare)
- Division of Neurodegeneration, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, 17165 Solna, Sweden
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- Adameyko, Igor (författare)
- Department of Physiology and Pharmacology, Karolinska Institute, 17165 Solna, Sweden; Department of Neuroimmunology, Medical University of Vienna, 1090 Vienna, Austria
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- Lundeberg, Joakim (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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(creator_code:org_t)
- Engelska.
- Relaterad länk:
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https://doi.org/10.1...
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https://kth.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Heart development relies on a topologically defined interplay between a diverse array of cardiac cells. We finely curated spatial and single-cell measurements with subcellular imaging-based transcriptomics validation to explore spatial dynamics during early human cardiogenesis. Analyzing almost 80,000 individual cells and 70,000 spatially barcoded tissue regions between the 5.5th and 14th postconceptional weeks, we identified 31 coarse- and 72 fine-grained cell states and mapped them to highly resolved cardiac cellular niches. We provide novel insight into the development of the cardiac pacemaker-conduction system, heart valves, and atrial septum, and decipher heterogeneity of the hitherto elusive cardiac fibroblast population. Furthermore, we describe the formation of cardiac autonomic innervation and present the first spatial account of chromaffin cells in the fetal human heart. In summary, our study delineates the cellular and molecular landscape of the developing heart’s architecture, offering links to genetic causes of heart disease.
Ämnesord
- NATURVETENSKAP -- Biologi -- Utvecklingsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Developmental Biology (hsv//eng)
Publikations- och innehållstyp
- vet (ämneskategori)
- ovr (ämneskategori)
- Av författaren/redakt...
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Lázár, Enikő
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Mauron, Raphaël
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Andrusivova, Zan ...
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Foyer, Julia
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Larsson, Ludvig
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Shakari, Nick
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visa fler...
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Marco Salas, Ser ...
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Sariyar, Sanem
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Hansen, Jan Nikl ...
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Vicari, Marco
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Czarnewski, Paul ...
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Braun, Emelie
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Li, Xiaofei
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Bergmann, Olaf
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Sylvén, Christer
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Käller Lundberg, ...
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Linnarsson, Sten
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Nilsson, Mats
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Sundström, Erik
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Adameyko, Igor
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Lundeberg, Joaki ...
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Utvecklingsbiolo ...
- Av lärosätet
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Kungliga Tekniska Högskolan