WFRF:(Tell A.)
Sökning: WFRF:(Tell A.) > Vitamin B6 cataboli...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 07380naa a2200985 4500 | |
| 001 | oai:lup.lub.lu.se:e9447c24-a56c-4f94-8661-7375d4771ad0 | |
| 003 | SwePub | |
| 008 | 190502s2019 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-158604 | |
| 024 | 7 | a https://lup.lub.lu.se/record/e9447c24-a56c-4f94-8661-7375d4771ad02 URI |
| 024 | 7 | a https://doi.org/10.1093/annonc/mdz0022 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1586042 URI |
| 040 | a (SwePub)lud (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Zuo, H.u University of Bergen4 aut |
| 245 | 1 0 | a Vitamin B6 catabolism and lung cancer risk : Results from the Lung Cancer Cohort Consortium (LC3) |
| 264 | 1 | b Elsevier BV,c 2019 |
| 300 | a 8 s. | |
| 520 | a Background Increased vitamin B6 catabolism related to inflammation, as measured by the PAr index (the ratio of 4-pyridoxic acid over the sum of pyridoxal and pyridoxal-5'-phosphate), has been positively associated with lung cancer risk in two prospective European studies. However, the extent to which this association translates to more diverse populations is not known. Materials and methods For this study, we included 5323 incident lung cancer cases and 5323 controls individually matched by age, sex, and smoking status within each of 20 prospective cohorts from the Lung Cancer Cohort Consortium. Cohort-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between PAr and lung cancer risk were calculated using conditional logistic regression and pooled using random-effects models. Results PAr was positively associated with lung cancer risk in a dose-response fashion. Comparing the fourth versus first quartiles of PAr resulted in an OR of 1.38 (95% CI: 1.19-1.59) for overall lung cancer risk. The association between PAr and lung cancer risk was most prominent in former smokers (OR: 1.69, 95% CI: 1.36-2.10), men (OR: 1.60, 95% CI: 1.28-2.00), and for cancers diagnosed within 3 years of blood draw (OR: 1.73, 95% CI: 1.34-2.23). Conclusion Based on pre-diagnostic data from 20 cohorts across 4 continents, this study confirms that increased vitamin B6 catabolism related to inflammation and immune activation is associated with a higher risk of developing lung cancer. Moreover, PAr may be a pre-diagnostic marker of lung cancer rather than a causal factor. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a inflammation | |
| 653 | a lung cancer | |
| 653 | a Lung Cancer Cohort Consortium | |
| 653 | a nested case-control study | |
| 653 | a PAr | |
| 653 | a vitamin B6 | |
| 653 | a PAr | |
| 700 | 1 | a Ueland, P. M.u University of Bergen,Haukeland University Hospital,Bevital AS,Fred Hutchinson Cancer Research Center4 aut |
| 700 | 1 | a Tell, G. S.u University of Bergen,University of Paris-Saclay,Human Genetics Foundation (HuGeF)4 aut |
| 700 | 1 | a Fanidi, A.u University of Cambridge,International Agency for Research on Cancer, World Health Organization4 aut |
| 700 | 1 | a Zheng, W.u Vanderbilt University4 aut |
| 700 | 1 | a Shu, X.u Vanderbilt University4 aut |
| 700 | 1 | a Xiang, Y.u Renji Hospital4 aut |
| 700 | 1 | a Wu, J.u Vanderbilt University4 aut0 (Swepub:lu)med-jwu |
| 700 | 1 | a Prentice, R.u Fred Hutchinson Cancer Research Center4 aut |
| 700 | 1 | a Pettinger, M.u Fred Hutchinson Cancer Research Center4 aut |
| 700 | 1 | a Thomson, C. A.u University of Arizona4 aut |
| 700 | 1 | a Giles, G. G.u University of Melbourne,Cancer Council Victoria,National Cancer Institute, USA4 aut |
| 700 | 1 | a Hodge, A.u Cancer Council Victoria,University of Melbourne4 aut |
| 700 | 1 | a Cai, Q.u Vanderbilt University4 aut |
| 700 | 1 | a Blot, W. J.u Vanderbilt University4 aut |
| 700 | 1 | a Johansson, Mikaelu Umeå universitet,Umeå University,Onkologi4 aut0 (Swepub:umu)mijo0025 |
| 700 | 1 | a Hultdin, Johanu Umeå universitet,Umeå University,Klinisk kemi4 aut0 (Swepub:umu)johu0007 |
| 700 | 1 | a Grankvist, Kjellu Umeå universitet,Umeå University,Klinisk kemi4 aut0 (Swepub:umu)kjgr0002 |
| 700 | 1 | a Stevens, V. L.u American Cancer Society4 aut |
| 700 | 1 | a McCullough, M. L.u American Cancer Society4 aut |
| 700 | 1 | a Weinstein, S. J.u National Cancer Institute, USA4 aut |
| 700 | 1 | a Albanes, D.u National Cancer Institute, USA4 aut |
| 700 | 1 | a Ziegler, R. G.u National Cancer Institute, USA4 aut |
| 700 | 1 | a Freedman, N. D.u National Cancer Institute, USA4 aut |
| 700 | 1 | a Caporaso, N. E.u National Cancer Institute, USA4 aut |
| 700 | 1 | a Langhammer, A.u Norwegian University of Science and Technology4 aut |
| 700 | 1 | a Hveem, K.u Norwegian University of Science and Technology4 aut |
| 700 | 1 | a Næss, M.u Norwegian University of Science and Technology4 aut |
| 700 | 1 | a Buring, J. E.u Harvard University,Brigham and Women's Hospital / Harvard Medical School4 aut |
| 700 | 1 | a Lee, I.u Harvard University,Brigham and Women's Hospital / Harvard Medical School4 aut |
| 700 | 1 | a Gaziano, J. M.u Boston Veteran's Administration (VA) Healthcare,Brigham and Women's Hospital / Harvard Medical School,Harvard University4 aut |
| 700 | 1 | a Severi, G.u University of Paris-Saclay,Human Genetics Foundation (HuGeF)4 aut |
| 700 | 1 | a Zhang, X.u Harvard University,Brigham and Women's Hospital / Harvard Medical School4 aut |
| 700 | 1 | a Stampfer, M. J.u Brigham and Women's Hospital / Harvard Medical School,Harvard University4 aut |
| 700 | 1 | a Han, J.u Indiana University4 aut |
| 700 | 1 | a Zeleniuch-Jacquotte, A.u New York University4 aut |
| 700 | 1 | a Marchand, L. L.u University of Hawai'i at Hilo4 aut |
| 700 | 1 | a Yuan, J.u University of Pittsburgh Medical Center4 aut |
| 700 | 1 | a Wang, R.u University of Pittsburgh Medical Center4 aut |
| 700 | 1 | a Koh, W.u National University of Singapore4 aut |
| 700 | 1 | a Gao, Y.u Shanghai Jiao Tong University4 aut |
| 700 | 1 | a Ericson, U.u Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)medf-upe |
| 700 | 1 | a Visvanathan, K.u Johns Hopkins University School of Medicine4 aut |
| 700 | 1 | a Jones, M. R.u Johns Hopkins University4 aut |
| 700 | 1 | a Relton, C.u University of Bristol,University of Newcastle upon Tyne4 aut |
| 700 | 1 | a Brennan, P.u International Agency for Research on Cancer, World Health Organization4 aut |
| 700 | 1 | a Johansson, M.u International Agency for Research on Cancer, World Health Organization4 aut |
| 700 | 1 | a Ulvik, A.u Bevital AS4 aut |
| 710 | 2 | a University of Bergenb Haukeland University Hospital4 org |
| 773 | 0 | t Annals of Oncologyd : Elsevier BVg 30:3, s. 478-485q 30:3<478-485x 0923-7534x 1569-8041 |
| 856 | 4 | u http://dx.doi.org/10.1093/annonc/mdz002y FULLTEXT |
| 856 | 4 | u http://www.annalsofoncology.org/article/S0923753419310828/pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/e9447c24-a56c-4f94-8661-7375d4771ad0 |
| 856 | 4 8 | u https://doi.org/10.1093/annonc/mdz002 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158604 |
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- Wu, J.
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- Weinstein, S. J.
- Albanes, D.
- Ziegler, R. G.
- Freedman, N. D.
- Caporaso, N. E.
- Langhammer, A.
- Hveem, K.
- Næss, M.
- Buring, J. E.
- Lee, I.
- Gaziano, J. M.
- Severi, G.
- Zhang, X.
- Stampfer, M. J.
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- Zeleniuch-Jacquo ...
- Marchand, L. L.
- Yuan, J.
- Wang, R.
- Koh, W.
- Gao, Y.
- Ericson, U.
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- Relton, C.
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