WFRF:(Thibblin Alf)
Sökning: WFRF:(Thibblin Alf) > The clinical safety...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03962naa a2200373 4500 | |
| 001 | oai:DiVA.org:uu-311184 | |
| 003 | SwePub | |
| 008 | 161222s2016 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3111842 URI |
| 024 | 7 | a https://doi.org/10.1186/s13550-016-0239-y2 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Somer, E. J.u GE Healthcare, Life Sci, Imaging R&D, Amersham, England.4 aut |
| 245 | 1 0 | a The clinical safety, biodistribution and internal radiation dosimetry of [F-18]AH113804 in healthy adult volunteers |
| 264 | c 2016-11-29 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2016 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Background: Quantitative biodistribution, venous blood and excretion data have been obtained following the intravenous bolus injection of AH113804 (F-18) Injection in six healthy volunteers (HVs), four males and two females, up to approximately 5 h post-injection. For each subject, key organs and tissues were delineated and analytical fits were made to the image data as functions of time to yield the normalised cumulated activities. These were input to an internal radiation dosimetry calculation based upon the Medical Internal Radiation Dose (MIRD) schema for the Cristy-Eckerman adult male or female phantom. The absorbed doses per unit administered activity to the 24 MIRD-specified target organs were evaluated for an assumed 3.5-h urinary bladder voiding interval using the Organ Level INternal Dose Assessment/Exponential Modelling (OLINDA/EXM) code. The sex-specific absorbed doses were then averaged, and the effective dose per unit administered activity was calculated. Results: Excluding the remaining tissue category, the three source regions with the highest mean initial F-18 activity uptake were the liver (18.3%), lung (5.1%) and kidney (4.5%) and the highest mean normalised cumulated activities were the urinary bladder contents and voided urine (1.057 MBq h/MBq), liver (0.129 MBq h/MBq) and kidneys (0.065 MBq h/MBq). The three organs/tissues with the highest mean sex-averaged absorbed doses per unit administered activity were the urinary bladder wall (0.351 mGy/MBq), kidneys (0.052 mGy/MBq) and uterus (0. 031 mGy/MBq). Conclusions: AH113804 (F-18) Injection was safe and well tolerated. Although the effective dose, 0.0298 mSv/MBq, is slightly greater than for other common F-18 PET imaging radiopharmaceuticals, the biodistribution and radiation dosimetry profile remain favourable for clinical PET imaging. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
| 700 | 1 | a Owenius, Rikardu Uppsala universitet,Radiologi,GE Healthcare, Life Sci, Imaging R&D, Uppsala, Sweden.4 aut0 (Swepub:uu)riowe227 |
| 700 | 1 | a Wall, Andersu Uppsala universitet,Radiologi4 aut0 (Swepub:uu)andewall |
| 700 | 1 | a Antoni, Gunnaru Uppsala universitet,Avdelningen för Molekylär Avbildning4 aut0 (Swepub:uu)gunnarat |
| 700 | 1 | a Thibblin, Alfu Uppsala universitet,Avdelningen för Molekylär Avbildning4 aut0 (Swepub:uu)alfthibb |
| 700 | 1 | a Sörensen, Jensu Uppsala universitet,Radiologi4 aut0 (Swepub:uu)jenssore |
| 710 | 2 | a GE Healthcare, Life Sci, Imaging R&D, Amersham, England.b Radiologi4 org |
| 773 | 0 | t EJNMMI Researchd : Springer Science and Business Media LLCg 6q 6x 2191-219X |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1059374/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://ejnmmires.springeropen.com/track/pdf/10.1186/s13550-016-0239-y |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-311184 |
| 856 | 4 8 | u https://doi.org/10.1186/s13550-016-0239-y |
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- Somer, E. J.
- Owenius, Rikard
- Wall, Anders
- Antoni, Gunnar
- Thibblin, Alf
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