MiR-155-5p positively regulates CCL17-induced colon cancer cell migration by targeting RhoA

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Fältnamn	Indikatorer	Metadata
000		03347naa a2200397 4500
001		oai:lup.lub.lu.se:24ab015f-7a4d-4b70-9fde-2b13658eae01
003		SwePub
008		170324s2017 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/24ab015f-7a4d-4b70-9fde-2b13658eae012 URI
024	7	a https://doi.org/10.18632/oncotarget.148412 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Al-Haidari, Amr A.u Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)med-ama
245	1 0	a MiR-155-5p positively regulates CCL17-induced colon cancer cell migration by targeting RhoA
264		c 2017-01-27
264	1	b Impact Journals, LLC,c 2017
300		a 10 s.
520		a Colorectal cancer is the second most common cause of cancer-related death, which is due to migration of tumor cells to distant sites of metastasis. Accumulating data indicate that mciroRNAs play an important role in several aspects of colon cancer cell biology. Herein, we examined the role of miR-155-5p in colon cancer cell migration induced by the CCL17-CCR4 axis in HT-29 colon cancer cells. We found that miR-155-5p knockdown in serum starved colon cancer cells decreased CCL17-induced cell chemotaxis. Moreover, knocking down miR-155-5p markedly decreased CCL17-provoked activation of RhoA in colon cancer cells. Bioinformatics analysis predicted two putative binding sites in the AU-rich element at the 3'-UTR of RhoA mRNA. MiR-155-5p binding to RhoA mRNA was verified using a target site blocker and functionally validated by RNA immunoprecipitation assays, showing that miR-155-5p-dependent regulation of RhoA mRNA is mediated by AU-rich elements present in the 3'-UTR region. Taken together, these results show that miR-155-5p positively regulates RhoA mRNA levels and translation as well as cell migration in serum starved colon cancer cells and indicate that targeting miR-155-5p might be a useful strategy to antagonize colon cancer metastasis.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653		a Chemokines
653		a Chemotaxis
653		a Colon cancer
653		a Metastasis
653		a MicroRNA
700	1	a Syk, Ingvaru Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kir-isy
700	1	a Thorlacius, Henriku Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kir-hth
710	2	a Kirurgib Forskargrupper vid Lunds universitet4 org
773	0	t Oncotargetd : Impact Journals, LLCg 8:9, s. 14887-14896q 8:9<14887-14896x 1949-2553
856	4	u http://dx.doi.org/10.18632/oncotarget.14841x freey FULLTEXT
856	4	u http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=14841&path%5B%5D=47408
856	4 8	u https://lup.lub.lu.se/record/24ab015f-7a4d-4b70-9fde-2b13658eae01
856	4 8	u https://doi.org/10.18632/oncotarget.14841

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Av författaren/redakt...: Al-Haidari, Amr ...; Syk, Ingvar; Thorlacius, Henr ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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