Sökning: WFRF:(Trichopoulos Dimitrios) > Adiposity, mediatin...
Fältnamn | Indikatorer | Metadata |
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000 | 05151naa a2200901 4500 | |
001 | oai:DiVA.org:umu-80827 | |
003 | SwePub | |
008 | 130926s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-808272 URI |
024 | 7 | a https://doi.org/10.1002/ijc.283682 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Aleksandrova, Krasimira4 aut |
245 | 1 0 | a Adiposity, mediating biomarkers and risk of colon cancer in the European prospective investigation into cancer and nutrition study |
264 | c 2013-11-20 | |
264 | 1 | b Wiley-Blackwell,c 2014 |
338 | a print2 rdacarrier | |
500 | a First published online 5 August 2013. | |
520 | a Adiposity is a risk factor for colon cancer, but underlying mechanisms are not well understood. We evaluated the extent to which 11 biomarkers with inflammatory and metabolic actions mediate the association of adiposity measures, waist circumference (WC) and body mass index (BMI), with colon cancer in men and women. We analyzed data from a prospective nested case-control study among 662 incident colon cancer cases matched within risk sets to 662 controls. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. The percent effect change and corresponding CIs were estimated after adjusting for biomarkers shown to be associated with colon cancer risk. After multivariable adjustment, WC was associated with colon cancer risk in men (top vs. bottom tertile RR 1.68, 95% CI 1.06-2.65; ptrend = 0.02) and in women (RR 1.67, 95% CI 1.09-2.56; ptrend = 0.03). BMI was associated with risk only in men. The association of WC with colon cancer was accounted mostly for by three biomarkers, high-density lipoprotein cholesterol, non-high-molecular-weight adiponectin and soluble leptin receptor, which in combination explained 46% (95% CI 37-57%) of the association in men and 50% (95% CI 40-65%) of the association in women. Similar results were observed for the associations with BMI in men. These data suggest that alterations in levels of these metabolic biomarkers may represent a primary mechanism of action in the relation of adiposity with colon cancer. Further studies are warranted to determine whether altering their concentrations may reduce colon cancer risk. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a colon cancer | |
653 | a adiposity | |
653 | a waist circumference | |
653 | a body mass index | |
653 | a mediating biomarkers | |
700 | 1 | a Drogan, Dagmar4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Jenab, Mazda4 aut |
700 | 1 | a Bas Bueno-de-Mesquita, H4 aut |
700 | 1 | a Jansen, Eugene4 aut |
700 | 1 | a van Duijnhoven, Fränzel J B4 aut |
700 | 1 | a Rinaldi, Sabina4 aut |
700 | 1 | a Fedirko, Veronika4 aut |
700 | 1 | a Romieu, Isabelle4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Gunter, Marc J4 aut |
700 | 1 | a Romaguera, Dora4 aut |
700 | 1 | a Westhpal, Sabine4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Tjønneland, Anne4 aut |
700 | 1 | a Halkjaer, Jytte4 aut |
700 | 1 | a Boutron-Ruault, Marie-Christine4 aut |
700 | 1 | a Clavel-Chapelon, Françoise4 aut |
700 | 1 | a Lukanova, Annekatrin4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a Vidalis, Pavlos4 aut |
700 | 1 | a Panico, Salvatore4 aut |
700 | 1 | a Agnoli, Claudia4 aut |
700 | 1 | a Palli, Domenico4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Buckland, Genevieve4 aut |
700 | 1 | a Sánchez-Cruz, José-Juan4 aut |
700 | 1 | a Dorronsoro, Miren4 aut |
700 | 1 | a Díaz, María José Tormo4 aut |
700 | 1 | a Barricarte, Aurelio4 aut |
700 | 1 | a Ramon Quiros, J4 aut |
700 | 1 | a Peeters, Petra H4 aut |
700 | 1 | a May, Anne M4 aut |
700 | 1 | a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001 |
700 | 1 | a Palmqvist, Richardu Umeå universitet,Patologi4 aut0 (Swepub:umu)ripa0001 |
700 | 1 | a Crowe, Francesca L4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Wareham, Nickolas4 aut |
700 | 1 | a Pischon, Tobias4 aut |
710 | 2 | a Umeå universitetb Näringsforskning4 org |
773 | 0 | t International Journal of Cancerd : Wiley-Blackwellg 134:3, s. 612-621q 134:3<612-621x 0020-7136x 1097-0215 |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.28368 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-80827 |
856 | 4 8 | u https://doi.org/10.1002/ijc.28368 |
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