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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 14902naa a2201297 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:146097305 | |
| 003 | SwePub | |
| 008 | 240818s2021 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-441002 | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1460973052 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-021-21287-02 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4410022 URI |
| 040 | a (SwePub)kid (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Huynh-Le, MPu Univ Calif San Diego, Dept Radiat Med & Appl Sci, La Jolla, CA 92093 USA.;Univ Calif San Diego, Ctr Multimodal Imaging & Genet, La Jolla, CA 92093 USA.4 aut |
| 245 | 1 0 | a Polygenic hazard score is associated with prostate cancer in multi-ethnic populations |
| 264 | c 2021-02-23 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2021 |
| 520 | a Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p < 10−180). Comparing the 80th/20th PHS2 percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS2 risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 700 | 1 | a Fan, CCu Univ Calif San Diego, Ctr Multimodal Imaging & Genet, La Jolla, CA 92093 USA.,Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland.4 aut |
| 700 | 1 | a Karunamuni, Ru Univ Calif San Diego, Dept Radiat Med & Appl Sci, La Jolla, CA 92093 USA.;Univ Calif San Diego, Ctr Multimodal Imaging & Genet, La Jolla, CA 92093 USA.4 aut |
| 700 | 1 | a Thompson, WKu Univ Calif San Diego, Div Biostat, La Jolla, CA 92093 USA.;Univ Calif San Diego, Halicioglu Data Sci Inst, La Jolla, CA 92093 USA.;Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA.4 aut |
| 700 | 1 | a Martinez, MEu Univ Calif San Diego, Dept Family Med & Publ Hlth, Moores Canc Ctr, La Jolla, CA USA.,Stanford Univ, Sch Med, Dept Med, Div Oncol,Stanford Canc Inst, Stanford, CA 94305 USA.4 aut |
| 700 | 1 | a Eeles, RAu Inst Canc Res, London, England.;Royal Marsden NHS Fdn Trust, London, England.,Univ Malaya, Dept Surg, Fac Med, Kuala Lumpur, Malaysia.4 aut |
| 700 | 1 | a Kote-Jarai, Zu Inst Canc Res, London, England.4 aut |
| 700 | 1 | a Muir, Ku Univ Manchester, Div Populat Hlth Hlth Serv Res & Primary Care, Oxford Rd, Manchester, Lancs, England.;Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England.4 aut |
| 700 | 1 | a Schleutker, Ju Univ Turku, Inst Biomed, Kiinamyllynkatu 10, FI-20014 Turku, Finland.;Turku Univ Hosp, Lab Div, Dept Med Genet, Genom, Turku, Finland.4 aut |
| 700 | 1 | a Pashayan, Nu UCL, Dept Appl Hlth Res, London, England.;Univ Cambridge, Dept Oncol, Strangeways Lab, Ctr Canc Genet Epidemiol, Worts Causeway, Cambridge, England.;UCL, Dept Appl Hlth Res, London, England.4 aut |
| 700 | 1 | a Batra, Ju Queensland Univ Technol, Australian Prostate Canc Res Ctr Qld, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia.;Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld, Australia.;Translat Res Inst, Brisbane, Qld, Australia.4 aut |
| 700 | 1 | a Gronberg, Hu Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.4 aut |
| 700 | 1 | a Neal, DEu Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg Sci, Oxford, England.;Univ Cambridge, Addenbrookes Hosp, Dept Oncol, Cambridge, England.;Li Ka Shing Ctr, Cambridge Res Inst, Canc Res UK, Cambridge, England.4 aut |
| 700 | 1 | a Donovan, JLu Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England.4 aut |
| 700 | 1 | a Hamdy, FCu Univ Oxford, Nuffield Dept Surg Sci, Oxford, England.;Univ Oxford, John Radcliffe Hosp, Fac Med Sci, Oxford, England.,Katholieke Univ Leuven, Mol Endocrinol Lab, Dept Cellular & Mol Med, Leuven, Belgium.4 aut |
| 700 | 1 | a Martin, RMu Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England.;Univ Bristol, Natl Inst Hlth Res NIHR, Biomed Res Ctr, Bristol, Avon, England.;Univ Bristol, Med Res Council MRC, Integrat Epidemiol Unit, Bristol, Avon, England.4 aut |
| 700 | 1 | a Nielsen, SFu Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Copenhagen, Denmark.4 aut |
| 700 | 1 | a Nordestgaard, BGu Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Copenhagen, Denmark.4 aut |
| 700 | 1 | a Wiklund, Fu Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.4 aut |
| 700 | 1 | a Tangen, CMu Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, 1124 Columbia St, Seattle, WA 98104 USA.,Humangenet Tuebingen, Tubingen, Germany.4 aut |
| 700 | 1 | a Giles, GGu Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Parkville, Vic, Australia.;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Clayton, Vic, Australia.,Univ Oxford, Nuffield Dept Surg Sci, Oxford, England.4 aut |
| 700 | 1 | a Wolk, Alicjau Uppsala universitet,Karolinska Institutet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, Stockholm, Sweden.4 aut0 (Swepub:uu)alwol516 |
| 700 | 1 | a Albanes, Du NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Travis, RCu Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.4 aut |
| 700 | 1 | a Blot, WJu Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, Nashville, TN USA.;Int Epidemiol Inst, Rockville, MD USA.4 aut |
| 700 | 1 | a Zheng, Wu Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, Nashville, TN USA.4 aut |
| 700 | 1 | a Sanderson, Mu Meharry Med Coll, Dept Family & Community Med, Nashville, TN 37208 USA.4 aut |
| 700 | 1 | a Stanford, JLu Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.4 aut |
| 700 | 1 | a Mucci, LAu Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.4 aut |
| 700 | 1 | a West, CMLu Univ Manchester, Manchester Acad Hlth Sci Ctr, Christie Hosp NHS Fdn Trust, Radiotherapy Related Res,Div Canc Sci, Manchester, Lancs, England.,Univ Rennes, Irset Inst Rech Sante Environm & Travail, INSERM, EHESP,UMR S 1085, Rennes, France.4 aut |
| 700 | 1 | a Kibel, ASu Brigham & Womens Hosp, Div Urol Surg, 75 Francis St, Boston, MA 02115 USA.4 aut |
| 700 | 1 | a Cussenot, Ou Sorbonne Univ, AP HP, GRC 5, 4 Rue Chine, Paris, France.;Tenon Hosp, CeRePP, Paris, France.4 aut |
| 700 | 1 | a Berndt, SIu NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Koutros, Su NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Sorensen, KDu Aarhus Univ Hosp, Dept Mol Med, Aarhus, Denmark.;Aarhus Univ, Dept Clin Med, Aarhus, Denmark.4 aut |
| 700 | 1 | a Cybulski, C4 aut |
| 700 | 1 | a Grindedal, EMu Oslo Univ Hosp, Dept Med Genet, Oslo, Norway.4 aut |
| 700 | 1 | a Menegaux, Fu Univ Paris Saclay, Univ Paris Sud, Ctr Res Epidemiol & Populat Hlth CESP, Canc & Environm Grp,INSERM, Villejuif, France.;Paris Sud Univ, UMRS 1018, Villejuif, France.4 aut |
| 700 | 1 | a Khaw, KTu Univ Cambridge, Clin Gerontol Unit, Cambridge, England.4 aut |
| 700 | 1 | a Park, JYu H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA.4 aut |
| 700 | 1 | a Ingles, SAu Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90007 USA.4 aut |
| 700 | 1 | a Maier, C4 aut |
| 700 | 1 | a Hamilton, RJu Princess Margaret Canc Ctr, Dept Surg Oncol, Toronto, ON, Canada.;Univ Toronto, Dept Surg Urol, Toronto, ON, Canada.4 aut |
| 700 | 1 | a Thibodeau, SNu Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA.4 aut |
| 700 | 1 | a Rosenstein, BSu Icahn Sch Med Mt Sinai, Dept Radiat Oncol, One Gustave L Levy Pl, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, One Gustave L Levy Pl, New York, NY 10029 USA.4 aut |
| 700 | 1 | a Lu, YJu Queen Mary Univ London, Barts Canc Inst, John Vane Sci Ctr, Ctr Mol Oncol, Charterhouse Sq, London, England.4 aut |
| 700 | 1 | a Watya, Su Uro Care, Kampala, Uganda.4 aut |
| 700 | 1 | a Vega, Au Fdn Publ Galega Medicina Xen, Santiago De Compostela, Spain.;Inst Invest Sanitaria Santiago de Compostela, Santiago De Compostela, Spain.;Ctr Invest Red Enfermedades Raras CIBERER, Santiago De Compostela, Spain.4 aut |
| 700 | 1 | a Kogevinas, Mu ISGlobal, Barcelona, Spain.;IMIM Hosp del Mar Med Res Inst, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain.4 aut |
| 700 | 1 | a Penney, KLu Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.4 aut |
| 700 | 1 | a Huff, Cu Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.4 aut |
| 700 | 1 | a Teixeira, MRu Portuguese Oncol Inst Porto IPO Porto, Dept Genet, Porto, Portugal.;Univ Porto, Biomed Sci Inst ICBAS, Porto, Portugal.4 aut |
| 700 | 1 | a Multigner, L4 aut |
| 700 | 1 | a Leach, RJu Univ Texas Hlth Sci Ctr San Antonio, Dept Urol, Mays Canc Ctr, San Antonio, TX 78229 USA.4 aut |
| 700 | 1 | a Cannon-Albright, Lu Univ Utah, Sch Med, Dept Internal Med, Div Epidemiol, Salt Lake City, UT USA.;George E Wahlen Dept Vet Affairs Med Ctr, Salt Lake City, UT USA.4 aut |
| 700 | 1 | a Brenner, Hu German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany.;German Canc Res Ctr, Div Prevent Oncol, Neuenheimer Feld 460, Heidelberg, Germany.;Natl Ctr Tumor Dis NCT, Neuenheimer Feld 460, Heidelberg, Germany.4 aut |
| 700 | 1 | a John, EM4 aut |
| 700 | 1 | a Kaneva, Ru Med Univ Sofia, Dept Med Chem & Biochem, Mol Med Ctr, Sofia, Bulgaria.4 aut |
| 700 | 1 | a Logothetis, CJu Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA.4 aut |
| 700 | 1 | a Neuhausen, SLu City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA USA.4 aut |
| 700 | 1 | a De Ruyck, Ku Univ Ghent, Fac Med & Hlth Sci, Basic Med Sci, Ghent, Belgium.4 aut |
| 700 | 1 | a Pandha, Hu Univ Surrey, Guildford, Surrey, England.4 aut |
| 700 | 1 | a Razack, A4 aut |
| 700 | 1 | a Newcomb, LFu Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Dept Urol, Seattle, WA 98195 USA.4 aut |
| 700 | 1 | a Fowke, JHu Vanderbilt Univ, Med Ctr, Dept Med & Urol Surg, Nashville, TN USA.;Univ Tennessee, Hlth Sci Ctr, Dept Prevent Med, Div Epidemiol, Memphis, TN USA.4 aut |
| 700 | 1 | a Gamulin, Mu Univ Zagreb, Sch Med, Univ Hosp Ctr Zagreb, Dept Oncol, Zagreb, Croatia.4 aut |
| 700 | 1 | a Usmani, Nu Univ Alberta, Cross Canc Inst, Dept Oncol, Edmonton, AB, Canada.;Cross Canc Inst, Div Radiat Oncol, Edmonton, AB, Canada.4 aut |
| 700 | 1 | a Claessens, F4 aut |
| 700 | 1 | a Gago-Dominguez, Mu Complejo Hosp Univ Santiago, Inst Invest Sanitaria Santiago de Compostela IDIS, Galician Fdn Genom Med, Genom Med Grp,Serv Galego Saude,SERGAS, Santiago De Compostela, Spain.;Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA.4 aut |
| 700 | 1 | a Townsend, PAu Univ Manchester, NIHR Manchester Biomed Res Ctr,Div Canc Sci, Manchester Acad Hlth Sci Ctr,Fac Biol Med & Hlth, Manchester Canc Res Ctr,Hlth Innovat Manchester, Manchester, Lancs, England.4 aut |
| 700 | 1 | a Bush, WSu Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland Inst Computat Biol, Cleveland, OH 44106 USA.4 aut |
| 700 | 1 | a Roobol, MJu Erasmus MC, Dept Clin Chem, Rotterdam, Netherlands.4 aut |
| 700 | 1 | a Parent, MEu Univ Turku, Inst Biomed, Kiinamyllynkatu 10, FI-20014 Turku, Finland.;Inst Natl Rech Sci, Ctr Armand Frappier Sante Biotechnol, Epidemiol & Biostat Unit, Laval, PQ, Canada.;Univ Montreal, Sch Publ Hlth, Dept Social & Prevent Med, Montreal, PQ, Canada.4 aut |
| 700 | 1 | a Hu, JJu Univ Miami, Sch Med, Sylvester Comprehens Canc Ctr, Miami, FL USA.4 aut |
| 700 | 1 | a Mills, IG4 aut |
| 700 | 1 | a Andreassen, OAu Oslo Univ Hosp, KG Jebsen Ctr, NORMENT, Oslo, Norway.;Univ Oslo, Oslo, Norway.4 aut |
| 700 | 1 | a Dale, AMu Univ Calif San Diego, Ctr Multimodal Imaging & Genet, La Jolla, CA 92093 USA.;Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA.4 aut |
| 700 | 1 | a Seibert, TMu Univ Calif San Diego, Dept Radiat Med & Appl Sci, La Jolla, CA 92093 USA.;Univ Calif San Diego, Ctr Multimodal Imaging & Genet, La Jolla, CA 92093 USA.;Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA.;Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA.4 aut |
| 710 | 2 | a Univ Calif San Diego, Dept Radiat Med & Appl Sci, La Jolla, CA 92093 USA.;Univ Calif San Diego, Ctr Multimodal Imaging & Genet, La Jolla, CA 92093 USA.b Univ Calif San Diego, Ctr Multimodal Imaging & Genet, La Jolla, CA 92093 USA.4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 12:1, s. 1236-q 12:1<1236-x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/s41467-021-21287-0.pdf |
| 856 | 4 | u https://doi.org/10.1038/s41467-021-21287-0y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1546791/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:146097305 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-021-21287-0 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-441002 |
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