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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004845naa a2200589 4500
001oai:DiVA.org:kth-207887
003SwePub
008170530s2017 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:135761557
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2078872 URI
0247 a https://doi.org/10.3389/fmicb.2017.007382 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1357615572 URI
040 a (SwePub)kthd (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Wampach, Lindau Karolinska Institutet4 aut
2451 0a Colonization and Succession within the Human Gut Microbiome by Archaea, Bacteria, and Microeukaryotes during the First Year of Life
264 c 2017-05-02
264 1b Frontiers Research Foundation,c 2017
338 a print2 rdacarrier
500 a QC 20170530
520 a Perturbations to the colonization process of the human gastrointestinal tract have been suggested to result in adverse health effects later in life. Although much research has been performed on bacterial colonization and succession, much less is known about the other two domains of life, archaea, and eukaryotes. Here we describe colonization and succession by bacteria, archaea and microeukaryotes during the first year of life (samples collected around days 1, 3, 5, 28, 150, and 365) within the gastrointestinal tract of infants delivered either vaginally or by cesarean section and using a combination of quantitative real-time PCR as well as 16S and 18S rRNA gene amplicon sequencing. Sequences from organisms belonging to all three domains of life were detectable in all of the collected meconium samples. The microeukaryotic community composition fluctuated strongly over time and early diversification was delayed in infants receiving formula milk. Cesarean section-delivered (CSD) infants experienced a delay in colonization and succession, which was observed for all three domains of life. Shifts in prokaryotic succession in CSD infants compared to vaginally delivered (VD) infants were apparent as early as days 3 and 5, which were characterized by increased relative abundances of the genera Streptococcus and Staphylococcus, and a decrease in relative abundance for the genera Bifidobacterium and Bacteroides. Generally, a depletion in Bacteroidetes was detected as early as day 5 postpartum in CSD infants, causing a significantly increased Firmicutes/Bacteroidetes ratio between days 5 and 150 when compared to VD infants. Although the delivery mode appeared to have the strongest influence on differences between the infants, other factors such as a younger gestational age or maternal antibiotics intake likely contributed to the observed patterns as well. Our findings complement previous observations of a delay in colonization and succession of CSD infants, which affects not only bacteria but also archaea and microeukaryotes. This further highlights the need for resolving bacterial, archaeal, and microeukaryotic dynamics in future longitudinal studies of microbial colonization and succession within the neonatal gastrointestinal tract.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
650 7a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng
653 a fungi
653 a succession
653 a delivery mode
653 a infant gut microbiome
653 a amplicon sequencing
653 a microbial colonization
653 a quantitative real-time PCR
7001 a Heintz-Buschart, Anna4 aut
7001 a Hogan, Angela4 aut
7001 a Muller, Emilie E. L.4 aut
7001 a Narayanasamy, Shaman4 aut
7001 a Laczny, Cedric C.4 aut
7001 a Hugerth, Luisa,d 1987-u KTH,Genteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1g7mwxd
7001 a Bindl, Lutz4 aut
7001 a Bottu, Jean4 aut
7001 a Andersson, Anders F.u KTH,Genteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1hi776x
7001 a de Beaufort, Carine4 aut
7001 a Wilmes, Paul4 aut
7102 a Karolinska Institutetb Genteknologi4 org
7730 t Frontiers in Microbiologyd : Frontiers Research Foundationg 8q 8x 1664-302X
8564 u https://www.frontiersin.org/articles/10.3389/fmicb.2017.00738/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-207887
8564 8u https://doi.org/10.3389/fmicb.2017.00738
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:135761557

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