Sökning: (WFRF:(Bos K)) srt2:(2020-2024) > (2022) > Effects of age, amy...
Fältnamn | Indikatorer | Metadata |
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000 | 04591naa a2200661 4500 | |
001 | oai:gup.ub.gu.se/316448 | |
003 | SwePub | |
008 | 240528s2022 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3164482 URI |
024 | 7 | a https://doi.org/10.1002/dad2.122862 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Wesenhagen, K. E. J.4 aut |
245 | 1 0 | a Effects of age, amyloid, sex, and APOE epsilon 4 on the CSF proteome in normal cognition |
264 | c 2022-05-06 | |
264 | 1 | b Wiley,c 2022 |
520 | a Introduction It is important to understand which biological processes change with aging, and how such changes are associated with increased Alzheimer's disease (AD) risk. We studied how cerebrospinal fluid (CSF) proteomics changed with age and tested if associations depended on amyloid status, sex, and apolipoprotein E sigma 4 genotype. Methods We included 277 cognitively intact individuals aged 46 to 89 years from Alzheimer's Disease Neuroimaging Initiative, European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery, and Metabolic Syndrome in Men. In total, 1149 proteins were measured with liquid chromatography mass spectrometry with multiple reaction monitoring/Rules-Based Medicine, tandem mass tag mass spectrometry, and SOMAscan. We tested associations between age and protein levels in linear models and tested enrichment for Reactome pathways. Results Levels of 252 proteins increased with age independently of amyloid status. These proteins were associated with immune and signaling processes. Levels of 21 proteins decreased with older age exclusively in amyloid abnormal participants and these were enriched for extracellular matrix organization. Discussion We found amyloid-independent and -dependent CSF proteome changes with older age, perhaps representing physiological aging and early AD pathology. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
653 | a cerebrospinal-fluid | |
653 | a alzheimers-disease | |
653 | a biomarkers | |
653 | a dementia | |
653 | a Neurosciences & Neurology | |
700 | 1 | a Gobom, Johanu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xgobjo |
700 | 1 | a Bos, I.4 aut |
700 | 1 | a Vos, S. J. B.4 aut |
700 | 1 | a Martinez-Lage, P.4 aut |
700 | 1 | a Popp, J.4 aut |
700 | 1 | a Tsolaki, M.4 aut |
700 | 1 | a Vandenberghe, R.4 aut |
700 | 1 | a Freund-Levi, Y.4 aut |
700 | 1 | a Verhey, F.4 aut |
700 | 1 | a Lovestone, S.4 aut |
700 | 1 | a Streffer, J.4 aut |
700 | 1 | a Dobricic, V.4 aut |
700 | 1 | a Bertram, L.4 aut |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Pikkarainen, M.4 aut |
700 | 1 | a Hallikainen, M.4 aut |
700 | 1 | a Kuusisto, J.4 aut |
700 | 1 | a Laakso, M.4 aut |
700 | 1 | a Soininen, H.4 aut |
700 | 1 | a Scheltens, P.4 aut |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Teunissen, C. E.4 aut |
700 | 1 | a Visser, P. J.4 aut |
700 | 1 | a Tijms, B. M.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Alzheimer's & Dementiad : Wileyg 14:1q 14:1x 1552-5260x 1552-5279 |
773 | 0 | t Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoringd : Wileyg 14:1q 14:1x 2352-8729x 2352-8729 |
856 | 4 8 | u https://gup.ub.gu.se/publication/316448 |
856 | 4 8 | u https://doi.org/10.1002/dad2.12286 |
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