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Sökning: (WFRF:(Boutron Ruault Marie Christine)) pers:(Panico Salvatore) > Citrus intake and r...

  • Mahamat-Saleh, YahyaUniversity of Paris-Saclay,Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP) (författare)

Citrus intake and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC)

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-07-24
  • Springer Science and Business Media LLC,2020
  • 11 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:a5cf8076-141e-47f6-921e-ade56347cb2e
  • https://lup.lub.lu.se/record/a5cf8076-141e-47f6-921e-ade56347cb2eURI
  • https://doi.org/10.1007/s10654-020-00666-9DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Citrus intake has been suggested to increase the risk of skin cancer. Although this relation is highly plausible biologically, epidemiologic evidence is lacking. We aimed to examine the potential association between citrus intake and skin cancer risk. EPIC is an ongoing multi-center prospective cohort initiated in 1992 and involving ~ 520,000 participants who have been followed-up in 23 centers from 10 European countries. Dietary data were collected at baseline using validated country-specific dietary questionnaires. We used Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (CI). During a mean follow-up of 13.7 years, 8448 skin cancer cases were identified among 270,112 participants. We observed a positive linear dose–response relationship between total citrus intake and skin cancer risk (HR = 1.10, 95% CI 1.03–1.18 in the highest vs. lowest quartile; Ptrend = 0.001), particularly with basal cell carcinoma (BCC) (HR = 1.11, 95% CI 1.02–1.20, Ptrend = 0.007) and squamous cell carcinoma (SCC) (HR = 1.23, 95% CI 1.04–1.47, Ptrend = 0.01). Citrus fruit intake was positively associated with skin cancer risk (HR = 1.08, 95% CI 1.01–1.16, Ptrend = 0.01), particularly with melanoma (HR = 1.23, 95% CI 1.02–1.48; Ptrend = 0.01), although with no heterogeneity across skin cancer types (Phomogeneity = 0.21). Citrus juice was positively associated with skin cancer risk (Ptrend = 0.004), particularly with BCC (Ptrend = 0.008) and SCC (Ptrend = 0.004), but not with melanoma (Phomogeneity = 0.02). Our study suggests moderate positive linear dose–response relationships between citrus intake and skin cancer risk. Studies with available biomarker data and the ability to examine sun exposure behaviors are warranted to clarify these associations and examine the phototoxicity mechanisms of furocoumarin-rich foods.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Cervenka, IrisInstitut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay (författare)
  • Al-Rahmoun, MarieCentre for Research in Epidemiology and Population Health (CESP),Institut Gustave Roussy,University of Paris-Saclay (författare)
  • Mancini, Francesca R.Centre for Research in Epidemiology and Population Health (CESP),Institut Gustave Roussy,University of Paris-Saclay (författare)
  • Severi, GianlucaCentre for Research in Epidemiology and Population Health (CESP),Institut Gustave Roussy,University of Paris-Saclay (författare)
  • Ghiasvand, RezaUniversity of Oslo (författare)
  • Veierod, Marit B.University of Oslo (författare)
  • Caini, SaverioInstitute for Cancer Research, Prevention and Clinical Network (ISPRO) (författare)
  • Palli, DomenicoInstitute for Cancer Research, Prevention and Clinical Network (ISPRO) (författare)
  • Botteri, EdoardoOslo university hospital (författare)
  • Sacerdote, CarlottaCentre for Cancer Epidemiology and Prevention (CPO Piemonte) (författare)
  • Ricceri, FulvioAzienda Sanitaria Locale Torino 3 (författare)
  • Trichopoulou, AntoniaHellenic Health Foundation, Athens (författare)
  • Peppa, EleniHellenic Health Foundation, Athens (författare)
  • La Vecchia, CarloUniversity of Milan,Hellenic Health Foundation, Athens (författare)
  • Overvad, KimAalborg University Hospital,Aarhus University (författare)
  • Dahm, Christina C.Aarhus University (författare)
  • Olsen, AnjaDanish Cancer Society (författare)
  • Tjønneland, AnneUniversity of Copenhagen,Danish Cancer Society (författare)
  • Perez-Cornago, AuroraUniversity of Oxford (författare)
  • Jakszyn, PaulaL'Hospitalet de Llobregat, Barcelona,Ramon Llull University (författare)
  • Grioni, SaraIstituto Nazionale dei Tumori (författare)
  • Schulze, Matthias B.German Institute of Human Nutrition,University of Potsdam (författare)
  • Skeie, GuriUiT The Arctic University of Norway, Tromsø (författare)
  • Lasheras, CristinaUniversity of Oviedo (författare)
  • Colorado-Yohar, SandraCIBER Epidemiology and Public Health (CIBERESP),University of Antioquia,Murcia Regional Health Council (författare)
  • Rodríguez-Barranco, MiguelAndalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP),University of Granada (författare)
  • Kühn, TilmanGerman Cancer Research Centre (författare)
  • Katzke, Verena A.German Cancer Research Centre (författare)
  • Amiano, PilarCIBER Epidemiology and Public Health (CIBERESP),Biodonostia Health Research Institute (författare)
  • Tumino, RosarioCivic and M.P Arezzo Hospital (författare)
  • Panico, SalvatoreUniversity of Naples Federico II (författare)
  • Ezponda, AnaUniversity Clinic of Navarra (författare)
  • Sonestedt, EmilyLund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups(Swepub:lu)medf-eso (författare)
  • Scalbert, AugustinInternational Agency for Research on Cancer, World Health Organization (författare)
  • Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization (författare)
  • Boutron-Ruault, Marie ChristineUniversity of Paris-Saclay,Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP) (författare)
  • Kvaskoff, MarinaUniversity of Paris-Saclay,Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP) (författare)
  • University of Paris-SaclayInstitut Gustave Roussy (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Journal of Epidemiology: Springer Science and Business Media LLC35:11, s. 1057-10670393-29901573-7284

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