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The role of plasma ...
The role of plasma microseminoprotein-beta in prostate cancer : An observational nested case-control and Mendelian randomization study in the European prospective investigation into cancer and nutrition
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- Smith Byrne, K. (författare)
- University of Oxford
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- Appleby, P. N. (författare)
- University of Oxford
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- Key, T. J. (författare)
- University of Oxford
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- Holmes, M. V. (författare)
- University of Bristol,University of Oxford
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- Fensom, G. K. (författare)
- University of Oxford
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- Agudo, A. (författare)
- Bellvitge Biomedical Research Institute
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- Ardanaz, E. (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
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- Boeing, H. (författare)
- German Institute of Human Nutrition
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- Bueno-De-Mesquita, H. B. (författare)
- Imperial College London,National Institute for Public Health and the Environment (RIVM),University of Malaya
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- Chirlaque, M. D. (författare)
- CIBER Epidemiology and Public Health (CIBERESP),University of Murcia
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- Kaaks, R. (författare)
- German Cancer Research Centre
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- Larranãga, N. (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Palli, D. (författare)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Perez-Cornago, A. (författare)
- University of Oxford
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- Quirós, J. R. (författare)
- Public Health Directorate
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- Ricceri, F. (författare)
- University of Turin
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- Sánchez, M. J. (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)
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- Tagliabue, G. (författare)
- Istituto Nazionale dei Tumori
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- Tsilidis, K. K. (författare)
- University of Ioannina,Imperial College London
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- Tumino, R. (författare)
- Civic and M.P Arezzo Hospital
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- Fortner, R. T. (författare)
- German Cancer Research Centre
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- Ferrari, P. (författare)
- International Agency for Research on Cancer, World Health Organization
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- Riboli, E. (författare)
- Imperial College London
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- Lilja, H. (författare)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,University of Oxford,Memorial Sloan-Kettering Cancer Center
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- Travis, R. C. (författare)
- University of Oxford
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- Engelska 7 s.
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Ingår i: Annals of Oncology. - : Elsevier BV. - 0923-7534. ; 30:6, s. 983-989
- Relaterad länk:
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http://dx.doi.org/10... (free)
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http://www.annalsofo...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Microseminoprotein-beta (MSP), a protein secreted by the prostate epithelium, may have a protective role in the development of prostate cancer. The only previous prospective study found a 2% reduced prostate cancer risk per unit increase in MSP. This work investigates the association of MSP with prostate cancer risk using observational and Mendelian randomization (MR) methods. Patients and methods: A nested case-control study was conducted with the European Prospective Investigation into Cancer and Nutrition (EPIC) with 1871 cases and 1871 matched controls. Conditional logistic regression analysis was used to investigate the association of pre-diagnostic circulating MSP with risk of incident prostate cancer overall and by tumour subtype. EPIC-derived estimates were combined with published data to calculate an MR estimate using two-sample inverse-variance method. Results: Plasma MSP concentrations were inversely associated with prostate cancer risk after adjusting for total prostate-specific antigen concentration [odds ratio (OR) highest versus lowest fourth of MSP = 0.65, 95% confidence interval (CI) 0.51-0.84, Ptrend = 0.001]. No heterogeneity in this association was observed by tumour stage or histological grade. Plasma MSP concentrations were 66% lower in rs10993994 TT compared with CC homozygotes (per allele difference in MSP: 6.09 ng/ml, 95% CI 5.56-6.61, r2=0.42). MR analyses supported a potentially causal protective association of MSP with prostate cancer risk (OR per 1 ng/ml increase in MSP for MR: 0.96, 95% CI 0.95-0.97 versus EPIC observational: 0.98, 95% CI 0.97-0.99). Limitations include lack of complete tumour subtype information and more complete information on the biological function of MSP. Conclusions: In this large prospective European study and using MR analyses, men with high circulating MSP concentration have a lower risk of prostate cancer. MSP may play a causally protective role in prostate cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- EPIC cohort
- Mendelian randomization
- microseminoprotein-beta
- prospective study
- prostate cancer
- prostate-specific antigen
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Smith Byrne, K.
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Appleby, P. N.
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Key, T. J.
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Holmes, M. V.
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Fensom, G. K.
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Agudo, A.
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visa fler...
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Ardanaz, E.
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Boeing, H.
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Bueno-De-Mesquit ...
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Chirlaque, M. D.
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Kaaks, R.
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Larranãga, N.
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Palli, D.
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Perez-Cornago, A ...
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Quirós, J. R.
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Ricceri, F.
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Sánchez, M. J.
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Tagliabue, G.
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Tsilidis, K. K.
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Tumino, R.
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Fortner, R. T.
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Ferrari, P.
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Riboli, E.
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Lilja, H.
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Travis, R. C.
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