Sökning: (WFRF:(Surakka Ida)) > Discovery and Fine-...
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000 | 17991naa a2201429 4500 | |
001 | oai:lup.lub.lu.se:9376a6a0-6b9b-4b1e-8f75-e4c9f79f087d | |
003 | SwePub | |
008 | 160401s2015 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:131936669 | |
009 | oai:DiVA.org:uu-263537 | |
024 | 7 | a https://lup.lub.lu.se/record/77511762 URI |
024 | 7 | a https://doi.org/10.1371/journal.pgen.10052302 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1319366692 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2635372 URI |
040 | a (SwePub)lud (SwePub)kid (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Horikoshi, Momokou Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.4 aut |
245 | 1 0 | a Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation. |
264 | c 2015-07-01 | |
264 | 1 | b Public Library of Science (PLoS),c 2015 |
338 | a electronic2 rdacarrier | |
520 | a Reference panels from the 1000 Genomes (1000G) Project Consortium provide near complete coverage of common and low-frequency genetic variation with minor allele frequency ≥0.5% across European ancestry populations. Within the European Network for Genetic and Genomic Epidemiology (ENGAGE) Consortium, we have undertaken the first large-scale meta-analysis of genome-wide association studies (GWAS), supplemented by 1000G imputation, for four quantitative glycaemic and obesity-related traits, in up to 87,048 individuals of European ancestry. We identified two loci for body mass index (BMI) at genome-wide significance, and two for fasting glucose (FG), none of which has been previously reported in larger meta-analysis efforts to combine GWAS of European ancestry. Through conditional analysis, we also detected multiple distinct signals of association mapping to established loci for waist-hip ratio adjusted for BMI (RSPO3) and FG (GCK and G6PC2). The index variant for one association signal at the G6PC2 locus is a low-frequency coding allele, H177Y, which has recently been demonstrated to have a functional role in glucose regulation. Fine-mapping analyses revealed that the non-coding variants most likely to drive association signals at established and novel loci were enriched for overlap with enhancer elements, which for FG mapped to promoter and transcription factor binding sites in pancreatic islets, in particular. Our study demonstrates that 1000G imputation and genetic fine-mapping of common and low-frequency variant association signals at GWAS loci, integrated with genomic annotation in relevant tissues, can provide insight into the functional and regulatory mechanisms through which their effects on glycaemic and obesity-related traits are mediated. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Mӓgi, Reedik4 aut |
700 | 1 | a van de Bunt, Martijnu Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.4 aut |
700 | 1 | a Surakka, Idau Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland.;Natl Inst Hlth & Welf, Helsinki, Finland.4 aut |
700 | 1 | a Sarin, Antti-Pekkau Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland.;Natl Inst Hlth & Welf, Helsinki, Finland.4 aut |
700 | 1 | a Mahajan, Anubhau Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.4 aut |
700 | 1 | a Marullo, Letiziau Univ Ferrara, Dept Life Sci & Biotechnol, I-44100 Ferrara, Italy.4 aut |
700 | 1 | a Thorleifsson, Gudmaru deCode Genet Amgen Inc, Reykjavik, Iceland.4 aut |
700 | 1 | a Hägg, Sarau Uppsala universitet,Karolinska Institutet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Karolinska Inst, Dept Med Epidemiol & Biostatist, Stockholm, Sweden.4 aut0 (Swepub:uu)sarha464 |
700 | 1 | a Hottenga, Jouke-Janu Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.,Vrije Univ Amsterdam, Dept Psychiat, Med Ctr, Amsterdam, Netherlands.4 aut |
700 | 1 | a Ladenvall, Claesu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skane Univ Hosp, Lund Univ Diabet Ctr, Dept Clin Sci Diabet & Endocrinol, Malmo, Sweden.4 aut0 (Swepub:lu)med-cll |
700 | 1 | a Ried, Janina Su Helmholtz Zentrum Munchen, Inst Genet Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany.4 aut |
700 | 1 | a Winkler, Thomas Wu Univ Regensburg, Dept Genet Epidemiol, Inst Epidemiol & Prevent Med, D-93053 Regensburg, Germany.4 aut |
700 | 1 | a Willems, Sara Mu Erasmus Univ, Med Ctr, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands.4 aut |
700 | 1 | a Pervjakova, Nataliau Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.4 aut |
700 | 1 | a Esko, Tõnuu Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.;Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA.;Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA 02115 USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.;Harvard Univ, Sch Med, Dept Genet, Boston, MA USA.4 aut |
700 | 1 | a Beekman, Marianu Leiden Univ, Med Ctr, Dept Mol Epidemiol, Leiden, Netherlands.;Netherlands Consortium Hlth Ageing, Leiden, Netherlands.4 aut |
700 | 1 | a Nelson, Christopher Pu Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Natl Inst Hlth Res, Leicester Cardiovasc Dis Biomed Res Unit, Glenfield Hosp, Leicester, Leics, England.4 aut |
700 | 1 | a Willenborg, Christinau Univ Lubeck, Inst Integrat & Expt Gen, Lubeck, Germany.;DZHK German Ctr Cardiovascular Res, Lubeck, Germany.4 aut |
700 | 1 | a Wiltshire, Stevenu Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.4 aut |
700 | 1 | a Ferreira, Teresau Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.4 aut |
700 | 1 | a Fernandez, Juanu Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.4 aut |
700 | 1 | a Gaulton, Kyle Ju Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.4 aut |
700 | 1 | a Steinthorsdottir, Valgerduru deCode Genet Amgen Inc, Reykjavik, Iceland.4 aut |
700 | 1 | a Hamsten, Andersu Karolinska Institutet,Karolinska Inst, Atherosclerosis Res Unit, Dept Med Solna, Cardiovascular Genet & Genom Grp, Stockholm, Sweden.4 aut |
700 | 1 | a Magnusson, Patrik K Eu Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostatist, Stockholm, Sweden.4 aut |
700 | 1 | a Willemsen, Gonnekeu Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.4 aut |
700 | 1 | a Milaneschi, Yuriu Vrije Univ Amsterdam, Dept Psychiat, Med Ctr, Amsterdam, Netherlands.4 aut |
700 | 1 | a Robertson, Neil Ru Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.4 aut |
700 | 1 | a Groves, Christopher Ju Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.4 aut |
700 | 1 | a Bennett, Amanda Ju Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.4 aut |
700 | 1 | a Lehtimӓki, Terhou Univ Tampere, Dept Clin Chem, Fimlab Labs, FIN-33101 Tampere, Finland.;Univ Tampere, Sch Med, FIN-33101 Tampere, Finland.4 aut |
700 | 1 | a Viikari, Jorma Su Univ Turku, Dept Med, Turku, Finland.;Turku Univ Hosp, Div Med, FIN-20520 Turku, Finland.4 aut |
700 | 1 | a Rung, Johanu European Bioinformat Inst, European Mol Biol Lab, Hinxton, England.4 aut |
700 | 1 | a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skane Univ Hosp, Lund Univ Diabet Ctr, Dept Clin Sci Diabet & Endocrinol, Malmo, Sweden.;Steno Diabet Ctr AS, Gentofte, Denmark.4 aut0 (Swepub:lu)endo-vly |
700 | 1 | a Perola, Markusu Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland.;Natl Inst Hlth & Welf, Helsinki, Finland.4 aut |
700 | 1 | a Heid, Iris Mu Univ Regensburg, Dept Genet Epidemiol, Inst Epidemiol & Prevent Med, D-93053 Regensburg, Germany.4 aut |
700 | 1 | a Herder, Christianu Univ Dusseldorf, Leibniz Inst Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany.;German Ctr Diabet Res DZD eV, Partner Dusseldorf, Dusseldorf, Germany.4 aut |
700 | 1 | a Grallert, Haraldu Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Neuherberg, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Neuherberg, Germany.4 aut |
700 | 1 | a Müller-Nurasyid, Martinau Helmholtz Zentrum Munchen, Inst Genet Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany.;Univ Munich, Univ Hosp Grosshadern, Dept Med 1, Munich, Germany.;Univ Munich, Inst Med Informat,Biometry & Epidemiol, Chair Genet Epidemiol, Munich, Germany.4 aut |
700 | 1 | a Roden, Michaelu Univ Dusseldorf, Leibniz Inst Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany.;German Ctr Diabet Res DZD eV, Partner Dusseldorf, Dusseldorf, Germany.;Univ Hosp Dusseldorf, Dept Endocrinol & Diabetol, Dusseldorf, Germany.4 aut |
700 | 1 | a Hypponen, Elinau Univ S Australia, Sch Populat Hlth, Adelaide, SA 5001, Australia.;UCL, Inst Child Hlth, Ctr Paediat Epidemiol & Biostat, London, England.4 aut |
700 | 1 | a Isaacs, Aaronu Erasmus Univ, Med Ctr, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands.;Ctr Med Syst Biol, Leiden, Netherlands.4 aut |
700 | 1 | a van Leeuwen, Elisabeth Mu Erasmus Univ, Med Ctr, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands.4 aut |
700 | 1 | a Karssen, Lennart Cu Erasmus Univ, Med Ctr, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands.4 aut |
700 | 1 | a Mihailov, Evelinu Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.4 aut |
700 | 1 | a Houwing-Duistermaat, Jeanine Ju Leiden Univ, Med Ctr, Dept Med Stat & Bioinformat, Leiden, Netherlands.4 aut |
700 | 1 | a de Craen, Anton J Mu Netherlands Consortium Hlth Ageing, Leiden, Netherlands.;Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, Leiden, Netherlands.,Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Turku, Finland.4 aut |
700 | 1 | a Deelen, Jorisu Leiden Univ, Med Ctr, Dept Mol Epidemiol, Leiden, Netherlands.;Netherlands Consortium Hlth Ageing, Leiden, Netherlands.4 aut |
700 | 1 | a Havulinna, Aki Su Natl Inst Hlth & Welf, Unit Chron Dis Epidemiol & Prevent, Helsinki, Finland.4 aut |
700 | 1 | a Blades, Matthewu Univ Leicester, Bioinformat & Biostatist Support Hub, Leicester, Leics, England.4 aut |
700 | 1 | a Hengstenberg, Christianu Tech Univ Munich, Deutsch Herzzentrum Munchen, D-80290 Munich, Germany.;DZHK German Ctr Cardiovasc Res, Munich, Germany.4 aut |
700 | 1 | a Erdmann, Jeanetteu Univ Lubeck, Inst Integrat & Expt Gen, Lubeck, Germany.;DZHK German Ctr Cardiovascular Res, Lubeck, Germany.4 aut |
700 | 1 | a Schunkert, Heribertu Tech Univ Munich, Deutsch Herzzentrum Munchen, D-80290 Munich, Germany.;DZHK German Ctr Cardiovasc Res, Munich, Germany.4 aut |
700 | 1 | a Kaprio, Jaakkou Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland.;Natl Inst Hlth & Welf, Helsinki, Finland.;Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.4 aut |
700 | 1 | a Tobin, Martin Du Univ Leicester, Dept Hlth Sci, Genet Epidemiol Grp, Leicester, Leics, England.;Natl Inst Hlth Res, Leicester Resp Biomed Res Unit, Glenfield Hosp, Leicester, Leics, England.4 aut |
700 | 1 | a Samani, Nilesh Ju Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Natl Inst Hlth Res, Leicester Cardiovasc Dis Biomed Res Unit, Glenfield Hosp, Leicester, Leics, England.4 aut |
700 | 1 | a Lind, Larsu Uppsala universitet,Karolinska Institutet,Kardiovaskulär epidemiologi,Karolinska Inst, Dept Med Epidemiol & Biostatist, Stockholm, Sweden.4 aut0 (Swepub:uu)larslind |
700 | 1 | a Salomaa, Veikkou Natl Inst Hlth & Welf, Unit Chron Dis Epidemiol & Prevent, Helsinki, Finland.4 aut |
700 | 1 | a Lindgren, Cecilia Mu Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Broad Inst Harvard & MIT, Broad Inst, Cambridge, MA USA.4 aut |
700 | 1 | a Slagboom, P Elineu Leiden Univ, Med Ctr, Dept Mol Epidemiol, Leiden, Netherlands.;Netherlands Consortium Hlth Ageing, Leiden, Netherlands.4 aut |
700 | 1 | a Metspalu, Andresu Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.;Univ Tartu, Inst Mol & Cell Biol, EE-50090 Tartu, Estonia.4 aut |
700 | 1 | a van Duijn, Cornelia Mu Erasmus Univ, Med Ctr, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands.;Ctr Med Syst Biol, Leiden, Netherlands.4 aut |
700 | 1 | a Eriksson, Johan Gu Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.;Folkhalsan Res Ctr, Helsinki, Finland.;Vasa Cent Hosp, Vaasa, Finland.;Natl Inst Hlth & Welf, Dept Hlth Promot & Chron Dis Prevent, Helsinki, Finland.4 aut |
700 | 1 | a Peters, Annetteu Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Neuherberg, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Neuherberg, Germany.4 aut |
700 | 1 | a Gieger, Christianu Helmholtz Zentrum Munchen, Inst Genet Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Neuherberg, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Neuherberg, Germany.4 aut |
700 | 1 | a Jula, Antti4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland.;Skane Univ Hosp, Lund Univ Diabet Ctr, Dept Clin Sci Diabet & Endocrinol, Malmo, Sweden.4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Raitakari, Olli Tu Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland.;Univ Turku, Dept Clin Physiol & Nucl Med, Turku, Finland.;Turku Univ Hosp, FIN-20520 Turku, Finland.4 aut |
700 | 1 | a Power, Chrisu UCL, Inst Child Hlth, Ctr Paediat Epidemiol & Biostat, London, England.4 aut |
700 | 1 | a Penninx, Brenda W J H4 aut |
700 | 1 | a de Geus, Ecou Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.;Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands.4 aut |
700 | 1 | a Smit, Johannes Hu Vrije Univ Amsterdam, Dept Psychiat, Med Ctr, Amsterdam, Netherlands.4 aut |
700 | 1 | a Boomsma, Dorret Iu Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.4 aut |
700 | 1 | a Pedersen, Nancy L4 aut |
700 | 1 | a Ingelsson, Eriku Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.4 aut0 (Swepub:uu)ering425 |
700 | 1 | a Thorsteinsdottir, Unnuru deCode Genet Amgen Inc, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.4 aut |
700 | 1 | a Stefansson, Kariu deCode Genet Amgen Inc, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.4 aut |
700 | 1 | a Ripatti, Samuliu Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland.;Natl Inst Hlth & Welf, Helsinki, Finland.;Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.;Wellcome Trust Sanger Inst, Cambridge, England.4 aut |
700 | 1 | a Prokopenko, Ingau Univ London Imperial Coll Sci Technol & Med, Dept Genom Common Dis, Sch Publ Hlth, London, England.4 aut |
700 | 1 | a McCarthy, Mark Iu Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Churchill Hosp, Biomed Res Ctr, Oxford Natl Inst Hlth Res, Oxford OX3 7LJ, England.4 aut |
700 | 1 | a Morris, Andrew Pu Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.;Univ Liverpool, Dept Biostat, Liverpool L69 3BX, Merseyside, England.;Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool, Merseyside, England.4 aut |
700 | 1 | a Maegi, Reediku Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.4 aut |
710 | 2 | a Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.b Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland.;Natl Inst Hlth & Welf, Helsinki, Finland.4 org |
773 | 0 | t PLoS Geneticsd : Public Library of Science (PLoS)g 11:7q 11:7x 1553-7404x 1553-7390 |
856 | 4 | u https://portal.research.lu.se/files/2391425/8596488.pdfx primaryx freey FULLTEXT |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/26132169?dopt=Abstractx freey FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1371/journal.pgen.1005230x freey FULLTEXT |
856 | 4 | u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005230&type=printable |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:858849/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://lup.lub.lu.se/record/7751176 |
856 | 4 8 | u https://doi.org/10.1371/journal.pgen.1005230 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:131936669 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-263537 |
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